100701-药物化学

天然产物化学

2014-09--2018-07   中国科学院大学   博士学位
2010-09--2013-07   云南中医药大学（与昆明植物研究所联合培养）   硕士学位
2006-09--2010-07   云南中医药大学   学士学位

   

2020-09~现在, 中国科学院昆明植物研究所, 岗位聘用
2018-07~2020-08,中国科学院昆明植物研究所, 项目聘用

博士研究生《有机化学》课程

   

[1] Jianjun Zhao, Shuzong Du, Kun Hu, Yali Hu, Fan Xia, Yansong Ye, Jian Yang, Yin Nian, Gang Xu. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides. CHINESE CHEMICAL LETTERS[J]. 2023, 34(4): 107737-, http://dx.doi.org/10.1016/j.cclet.2022.08.017.
[2] Qian Tan, Kun Hu, XiaoNian Li, XingZhi Yang, HanDong Sun, PemaTenzin Puno. Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii. BIOORGANIC CHEMISTRY[J]. 2023, 135: 106512-, http://dx.doi.org/10.1016/j.bioorg.2023.106512.
[3] Qi-Qi Zhang, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno. Four new lanostane triterpenoids featuring extended π -conjugated systems from the stems of Kadsura coccinea. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2023, 13(1): 1-8, http://dx.doi.org/10.1007/s13659-023-00376-1.
[4] XingRen Li, Kun Hu, BingChao Yan, XiaoNian Li, HanDong Sun, Yang Liu, PemaTenzin Puno. Scopariusicides D–M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused γ/δ-lactone core from Isodon scoparius. BIOORGANIC CHEMISTRY[J]. 2022, 127: 105973-, http://dx.doi.org/10.1016/j.bioorg.2022.105973.
[5] Qiu, CaiLing, Ye, ZhenNan, Yan, BingChao, Hu, Kun, Yang, Jin, Yang, XingZhi, Li, HongMei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Structurally diverse diterpenoids from Isodon oresbius and their bioactivity. BIOORGANIC CHEMISTRY[J]. 2022, 124: http://dx.doi.org/10.1016/j.bioorg.2022.105811.
[6] 陈素萍, 胡坤, 孙汉董, 普诺白玛丹增. 人工种植帚状香茶菜中木脂素类成分的研究. 云南中医学院学报. 2022, 45(6): 71-75, http://lib.cqvip.com/Qikan/Article/Detail?id=7108599516.
[7] Zhang Shuimei, Hu Kun, Li Xiaonian, Sun Handong, Puno Pematenzin. Lignans and sesquiterpenoids from the stems of Schisandra bicolor var.tuberculata. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2022, 12(3): http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7284150&detailType=1.
[8] Xia, JiangNan, Hu, Kun, Su, XiaoZheng, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Discovery of ent-kaurane diterpenoids, characteristic metabolites of Isodon species, from an endophytic fungal strain Geopyxis sp. XY93 inhabiting Isodon parvifolia. FITOTERAPIA[J]. 2022, 158: http://dx.doi.org/10.1016/j.fitote.2022.105160.
[9] Peng, Xingrong, Su, Haiguo, Wang, Huirong, Hu, Guilin, Hu, Kun, Zhou, Lin, Qiu, Minghua. Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 8(13): 3381-3389, http://dx.doi.org/10.1039/d1qo00294e.
[10] Zu, WenYu, Tang, JianWei, Hu, Kun, Zhou, YuanFei, Gou, LeiLei, Su, XiaoZheng, Lei, Xinxiang, Sun, HanDong, Puno, PemaTenzin. Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(1): 475-483, https://www.webofscience.com/wos/woscc/full-record/WOS:000606840200037.
[11] Ma, RenFen, Hu, Kun, Ding, WenPing, Wang, Bin, He, TaoBin, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Schipropins A-J, structurally diverse triterpenoids from Schisandra propinqua. PHYTOCHEMISTRY[J]. 2021, 182: https://www.webofscience.com/wos/woscc/full-record/WOS:000609228000001.
[12] Wu, Hai, Ding, Yiming, Hu, Kun, Long, Xianwen, Qu, Chunlei, Puno, PemaTenzin, Deng, Jun. Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(29): 15963-15971, http://dx.doi.org/10.1002/anie.202102831.
[13] Tang, Jianwei, Hu, Kun, Su, Xiaozheng, Li, Xiaonian, Yan, Bingchao, Sun, Handong, Puno, Pematenzin. Phomopsisins A-C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917. TETRAHEDRON[J]. 2020, 76(39): http://dx.doi.org/10.1016/j.tet.2020.131475.
[14] Dai, JiaMeng, Hu, Kun, Yan, BingChao, Li, XingRen, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(12): 3717-3725, https://www.webofscience.com/wos/woscc/full-record/WOS:000603402900026.
[15] He, TaoBin, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104353.
[16] Zhang, QinYu, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis. FITOTERAPIA[J]. 2020, 142: http://dx.doi.org/10.1016/j.fitote.2020.104529.
[17] Tang, JianWei, Kong, LingMei, Zu, WenYu, Hu, Kun, Li, XiaoNian, Yan, BingChao, Wang, WeiGuang, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. ORGANIC LETTERS[J]. 2019, 21(3): 771-775, http://ir.kib.ac.cn/handle/151853/64235.
[18] Xu, HouChao, Hu, Kun, Shi, XiaoHuo, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(10): 1619-1626, [19] Chen,Ling, Yang,Qian, Hu,Kun, Li,XiaoNian, Sun,HanDong, Puno,PemaTenzin. Isoforrethins A-D, four ent-abietane diterpenoids from Isodon forrestii var. forrestii. FITOTERAPIA[J]. 2019, 134: 158-164, http://dx.doi.org/10.1016/j.fitote.2019.02.026.
[20] Yang, Qian, Hu, Kun, Yan, BingChao, Liu, Miao, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Maoeriocalysins A-D, four novel ent-kaurane diterpenoids from Isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(1): 45-53, http://ir.kib.ac.cn/handle/151853/64294.
[21] Tang, JianWei, Xu, HouChao, Wang, WeiGuang, Hu, Kun, Zhou, YuanFei, Chen, Rong, Li, XiaoNian, Du, Xue, Sun, HanDong, Puno, PemaTenzin. (+)- and (-)-Alternarilactone A: Enantiomers with a Diepoxy-Cage-like Scaffold from an Endophytic Alternaria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(4): 735-740, http://ir.kib.ac.cn/handle/151853/66914.
[22] Hu, YaLi, Hu, Kun, Kong, LingMei, Xia, Fan, Yang, XingWei, Xu, Gang. Norascyronones A and B, 2,3,4-nor-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum ascyron. ORGANIC LETTERS[J]. 2019, 21(4): 1007-1010, http://ir.kib.ac.cn/handle/151853/64640.
[23] Tang, Yang, Zhao, ZhenZhu, Hu, Kun, Feng, Tao, Li, ZhengHui, Chen, HePing, Liu, JiKai. Irpexolidal Represents a Class of Triterpenoid from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(4): 1845-1852, http://ir.kib.ac.cn/handle/151853/65127.
[24] Hu Kun, Li XingRen, Tang JianWei, Li XiaoNian, Puno, PemaTenzin. Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2019, 17(12): 970-981, http://lib.cqvip.com/Qikan/Article/Detail?id=7100772593.
[25] Li, XingRen, Fu, Qiang, Zhou, Min, Hu, Kun, Du, Xue, Li, XiaoNian, Sun, HanDong, Yue, JianBo, Zhang, HongBin, Puno, PemaTenzin. Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2019, 21(10): 977-984, [26] Pu, DeBing, Du, BaoWen, Chen, Wen, Gao, JunBo, Hu, Kun, Shi, Nan, Li, YiMing, Zhang, XingJie, Zhang, RuiHan, Li, XiaoNian, Zhang, HongBin, Wang, Fei, Xiao, WeiLie. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva. ORGANIC LETTERS[J]. 2018, 20(19): 6314-6317, https://www.webofscience.com/wos/woscc/full-record/WOS:000447118200072.
[27] Shi, YiMing, Hu, Kun, Pescitelli, Gennaro, Liu, Miao, Li, XiaoNian, Du, Xue, Xiao, WeiLie, Sun, HanDong, Puno, PemaTenzin. Schinortriterpenoids with Identical Configuration but Distinct ECD Spectra Generated by Nondegenerate Exciton Coupling. ORGANIC LETTERS[J]. 2018, 20(6): 1500-1504, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003600006.
[28] Li, YanPing, Hu, Kun, Yang, XingWei, Xu, Gang. Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(4): 1098-1102, http://dx.doi.org/10.1021/acs.jnatprod.8b00017.
[29] Hu, ZhengXi, Liu, Miao, Wang, WeiGuang, Li, XiaoNian, Hu, Kun, Li, XingRen, Du, Xue, Zhang, YongHui, Puno, PemaTenzin, Sun, HanDong. 7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(1): 106-116, https://www.webofscience.com/wos/woscc/full-record/WOS:000423778900016.
[30] Hu, ZhengXi, Xu, HouChao, Hu, Kun, Liu, Miao, Li, XiaoNian, Li, XingRen, Du, Xue, Zhang, YongHui, Puno, PemaTenzin, Sun, HanDong. Structurally diverse diterpenoids from Isodon pharicus. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(15): 2379-2389, https://www.webofscience.com/wos/woscc/full-record/WOS:000439946500016.
[31] Ding, WenPing, Hu, Kun, Liu, Miao, Li, XingRen, Chen, Rong, Li, XiaoNian, Du, Xue, Puno, PemaTenzin, Sun, HanDong. Five new schinortriterpenoids from Schisandra propinqua var. propinqua. FITOTERAPIA[J]. 2018, 127: 193-200, http://dx.doi.org/10.1016/j.fitote.2018.02.019.
[32] Jiang, HuaYi, Wang, WeiGuang, Tang, JianWei, Liu, Miao, Li, XingRen, Hu, Kun, Du, Xue, Li, XiaoNian, Zhang, HongBin, Pu, JianXin, Sun, HanDong. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity. JOURNAL OF NATURAL PRODUCTS[J]. 2017, 80(7): 2026-2036, [33] Luo, YuanQing, Liu, Miao, Wen, Jin, Wang, WeiGuang, Hu, Kun, Li, XiaoNian, Du, Xue, Pu, JianXin, Sun, HanDong. Dibenzocyclooctadiene lignans from Kadsura heteroclita. FITOTERAPIA[J]. 2017, 119: 150-157, http://ir.kib.ac.cn/handle/151853/54456.
[34] Zhou, YuanFei, Shi, HaiXia, Hu, Kun, Tang, JianWei, Li, XingRen, Du, Xue, Sun, HanDong, Wang, LiSong, Pu, JianXin. Gypmacrophin A, a Rare Pentacyclic Sesterterpenoid, Together with Three Depsides, Functioned as New Chemical Evidence for Gypsoplaca macrophylla (Zahlbr.) Timdal Identification. MOLECULES[J]. 2017, 22(10): https://doaj.org/article/2b9acc11753a46e2b533ddcd10838a22.
[35] Zhang, YuanYuan, Jiang, HuaYi, Liu, Miao, Hu, Kun, Wang, WeiGuang, Du, Xue, Li, XiaoNian, Pu, JianXin, Sun, HanDong. Bioactive ent-kaurane diterpenoids from Isodon rubescens. PHYTOCHEMISTRY[J]. 2017, 143: 199-207, http://dx.doi.org/10.1016/j.phytochem.2017.08.009.
[36] Hu, ZhengXi, Hu, Kun, Shi, YiMing, Wang, WeiGuang, Du, Xue, Li, Yan, Zhang, YongHui, Pu, JianXin, Sun, HanDong. Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(10): 2590-2598, http://www.irgrid.ac.cn/handle/1471x/1175726.
[37] Hu, Kun, Liu, JieQing, Li, Xiaonian, Chen, JianChao, Zhang, WeiMing, Li, Yan, Li, Liangqun, Guo, Linlin, Ma, Weiguang, Qiu, MingHua. Chukfuransins A-D, Four New Phragmalin Limonoids with beta-Furan Ring Involved in Skeleton Reconstruction from Chukrasia tabularis. ORGANIC LETTERS[J]. 2013, 15(15): 3902-3905, https://www.webofscience.com/wos/woscc/full-record/WOS:000322853000026.

   

（ 1 ） 量子化学计算与各向异性核磁方法在“一科一属”植物复杂天然产物结构确证中的运用, 负责人, 国家任务, 2020-01--2022-12
（ 2 ） 计算模拟与核磁共振技术助力的天然产物结构与功能研究, 负责人, 中国科学院计划, 2023-01--2027-01
（ 3 ） 天然产物结构确证中量子化学计算方法的自动化及其应用研究, 负责人, 地方任务, 2021-06--2024-05
（ 4 ） 黑老虎与大花五味子的化学成分及其生物活性研究, 负责人, 研究所自选, 2022-07--2024-12