General
胡志远 男 汉族 博导 国家纳米科学中心
Email: huzy@nanoctr.cn
Telephone: 010-82545643
Address: 北京市海淀区中关村北一条11号
Postcode: 100190
Email: huzy@nanoctr.cn
Telephone: 010-82545643
Address: 北京市海淀区中关村北一条11号
Postcode: 100190
Research Areas
Biochemistry
Education
B.S. Genetics, 1995, Fudan University, Shanghai, China.
Ph.D. Biological Chemistry, 2005, Johns Hopkins University, Baltimore, MD. U.S.A.
Ph.D. Biological Chemistry, 2005, Johns Hopkins University, Baltimore, MD. U.S.A.
Experience
Work Experience
11/2010-present
Professor
National Center for Nanoscience and Technology, China
05/2009-present
Professor
Beijing Proteome Research Center
03/2007-11/2010
Research Scientist, Leroy Hood Lab,
Institute for Systems Biology, Seattle, WA
Integrated diagnostics of liver diseases and cancers
03/2006-03/2007
Postdoctoral fellow, Leroy Hood Lab,
Institute for Systems Biology, Seattle, WA
Protein microarray, blood proteomics
04/2005-03/2006
Postdoctoral fellow, Daniel Lane Lab,
Johns Hopkins University, Baltimore, MD
Molecular regulation of hypothalamic neurons, obesity
06/2000-03/2005
Predoctoral fellow, Daniel Lane Lab,
Johns Hopkins University, Baltimore, MD
Fatty acid metabolism in hypothalamus
12/1994-12/1999
Research associate and graduate student, Fuchu He Lab,
Beijing Institute of Radiation Medicine, Beijing
Stem cells, proteomics
Professor
National Center for Nanoscience and Technology, China
05/2009-present
Professor
Beijing Proteome Research Center
03/2007-11/2010
Research Scientist, Leroy Hood Lab,
Institute for Systems Biology, Seattle, WA
Integrated diagnostics of liver diseases and cancers
03/2006-03/2007
Postdoctoral fellow, Leroy Hood Lab,
Institute for Systems Biology, Seattle, WA
Protein microarray, blood proteomics
04/2005-03/2006
Postdoctoral fellow, Daniel Lane Lab,
Johns Hopkins University, Baltimore, MD
Molecular regulation of hypothalamic neurons, obesity
06/2000-03/2005
Predoctoral fellow, Daniel Lane Lab,
Johns Hopkins University, Baltimore, MD
Fatty acid metabolism in hypothalamus
12/1994-12/1999
Research associate and graduate student, Fuchu He Lab,
Beijing Institute of Radiation Medicine, Beijing
Stem cells, proteomics
Honors & Distinctions
• National military science and development awards (Beijing Institute of Radiation Medicine). 1997, 1998
• Annual award for outstanding researcher (Beijing Institute of Radiation Medicine). 1995
• Annual award for outstanding researcher (Beijing Institute of Radiation Medicine). 1995
Publications
Papers
Lausted C, Hu Z, Hood L. Label-free detection with surface plasmon resonance imaging. Methods Mol Biol. (2011);723: 321-33.
Lausted C, Hu Z, Hood L, Campbell CT. SPR imaging for high throughput, label-free interaction analysis. Comb Chem High Throughput Screen. (2009); 12(8): 741-51.
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood L, and Galas D. Circulating microRNAs, a new class of blood biomarker for drug- induced liver injury. Proc Natl Acad Sci U S A. (2009); 106(11): 4402-7
Lausted C*, Hu Z*, Hood L. Quantitative serum proteomics from surface plasmon resonance imaging. Mol Cell Proteomics. (2008); 7(12): 2464–2474 (* corresponding author, co-first author)
Hu Z, Hood L and Tian Q. Quantitative Proteomic Approaches for Biomarker Discovery. Proteomics-Clinical Applications. (invite review) (2007); 1(9): 1036-41
Chakravarthy MV, Zhu Y, Lopez M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest. (2007); 117(9): 2539-52
Hu Z, Cha SH, van Haasteren G, Wang J and Lane MD. Effect of centrally-administered C75, a FAS inhibitor, on ghrelin secretion and its downstream effects. PNAS. (2005); 102(11): 3972-7
Hu Z, Dai Y, Chohnan S and Lane MD. Role of hypothalamic malonyl-CoA in the control of food intake. J Biol. Chem. (2005); 280(48): 39681-3
Dowell P, Hu Z, Lane MD. Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. (invite review) Annu. Rev. Biochem. (2005): 74: 515-534
Cha SH, Hu Z and Lane MD. Centrally administered C75, a fatty acid synthase inhibitor, rapidly activates fatty acid oxidation in skeletal muscle. PNAS. (2005); 102(41): 14557-62
Hu Z, Cha SH, Chohnan S, Lane MD. Hypothalamic malonyl-CoA as a mediator of feeding behavior. PNAS. (2003); 100(22): 12624-9
Lausted C, Hu Z, Hood L, Campbell CT. SPR imaging for high throughput, label-free interaction analysis. Comb Chem High Throughput Screen. (2009); 12(8): 741-51.
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood L, and Galas D. Circulating microRNAs, a new class of blood biomarker for drug- induced liver injury. Proc Natl Acad Sci U S A. (2009); 106(11): 4402-7
Lausted C*, Hu Z*, Hood L. Quantitative serum proteomics from surface plasmon resonance imaging. Mol Cell Proteomics. (2008); 7(12): 2464–2474 (* corresponding author, co-first author)
Hu Z, Hood L and Tian Q. Quantitative Proteomic Approaches for Biomarker Discovery. Proteomics-Clinical Applications. (invite review) (2007); 1(9): 1036-41
Chakravarthy MV, Zhu Y, Lopez M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest. (2007); 117(9): 2539-52
Hu Z, Cha SH, van Haasteren G, Wang J and Lane MD. Effect of centrally-administered C75, a FAS inhibitor, on ghrelin secretion and its downstream effects. PNAS. (2005); 102(11): 3972-7
Hu Z, Dai Y, Chohnan S and Lane MD. Role of hypothalamic malonyl-CoA in the control of food intake. J Biol. Chem. (2005); 280(48): 39681-3
Dowell P, Hu Z, Lane MD. Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. (invite review) Annu. Rev. Biochem. (2005): 74: 515-534
Cha SH, Hu Z and Lane MD. Centrally administered C75, a fatty acid synthase inhibitor, rapidly activates fatty acid oxidation in skeletal muscle. PNAS. (2005); 102(41): 14557-62
Hu Z, Cha SH, Chohnan S, Lane MD. Hypothalamic malonyl-CoA as a mediator of feeding behavior. PNAS. (2003); 100(22): 12624-9
Patents
Biomarkers for liver injury. US 12/785279 Patent Published. USA. Publication Date 11/25/2010
Human hepatopoietin. P. R. China. Pat. No. 1,060,520. Sept. 10, 1997
Method of over-expression and purification of thrombopoietin. P. R. China. Pat. No. 1,185,485. June 24, 1998
Method of over-expression and purification of a recombinant human gamma interferon variant. P. R. China. Pat. No. 1,257,125. June 21, 2000
Human hepatopoietin. P. R. China. Pat. No. 1,060,520. Sept. 10, 1997
Method of over-expression and purification of thrombopoietin. P. R. China. Pat. No. 1,185,485. June 24, 1998
Method of over-expression and purification of a recombinant human gamma interferon variant. P. R. China. Pat. No. 1,257,125. June 21, 2000
Research Interests
Integrated diagnostics of liver diseases and cancers
Protein microarray, blood proteomics
Molecular regulation of hypothalamic neurons, obesity
peptide and protein research based on microfluidic chips
Conferences
Protein Microarray Technology and Liver Biomarkers
7th CNHUPO Annul Meeting
Supporting Technologies for Proteomics
Invited Speaker
April 2011 Hangzhou, Zhejiang, China
Quantitative Liver-specific Blood Protein Fingerprint A Signature for Hepatotoxicity
World Pharmaceutical Congress 2010
Early Assessments for Predicting Hepatotoxicity
Invited Speaker
June 2010, Philadelphia PA
Novel Protein Markers and Platforms
AASLD 2010 Heptotoxicity Meeting
Drug Induced Liver Injury: Getting the Medicine and Science Together
Invited Speaker
March 2010, Silver Spring MD
Surface Plasmon Resonance Imaging (SPRI) Protein Microarray
6th CNHUPO Annul Meeting
Supporting Technologies for Proteomics
Chairperson
July 2009 Taizhou, Jiangsu, China
Surface Plasmon Resonance Imaging (SPRI) Antibody Array in Biomarker Discovery
International Congress of Antibodies
Invited speaker
May 2009 Beijing China
A Protein Chip for Hepatotoxicity.
World Pharmaceutical Congress 2008
Hepatotoxity and Drug Safety
Invited Speaker
May 2008 Philadelphia PA
Protein chips application in hepatotoxicity and cancer diagnostics.
Life Science Annual Conference 2008
Cancer Prevention and Control
Invited Plenary Speaker
April 2008 Beijing China
A panel of liver specific blood biomarkers.
Preclinical Safety Testing Consortium (PSTC) Annual Meeting
Hepatotoxicity session
Invited speaker
March 2008 Seattle WA
Quantitative Proteomics by Surface Plasmon Resonance Based Antibody Microarrays.
1st. International Conference on Toxicogenomics Integrated with Environmental Sciences
Invited Plenary Speaker
Oct. 2007 Raleigh NC
Selected Serum Proteome Analyses of Drug Induced Liver Injury.
by Surface Plasmon Resonance Antibody Microarray.
US HUPO Third Annual Conference—from genes to function
Plenary Speaker
March 2007 Seattle WA
A Prototype SPR Antibody Microarray for Blood Biomarker Discovery.
NSBCC Annual Retreat
Oral presentation
Feb. 2007 Ventura CA
Role of Malonyl-CoA in the hypothalamic control of food intake.
The Mid-Atlantic Diabetes Research Symposium
Invited Speaker
Sept. 2003 Bethesda MD
7th CNHUPO Annul Meeting
Supporting Technologies for Proteomics
Invited Speaker
April 2011 Hangzhou, Zhejiang, China
Quantitative Liver-specific Blood Protein Fingerprint A Signature for Hepatotoxicity
World Pharmaceutical Congress 2010
Early Assessments for Predicting Hepatotoxicity
Invited Speaker
June 2010, Philadelphia PA
Novel Protein Markers and Platforms
AASLD 2010 Heptotoxicity Meeting
Drug Induced Liver Injury: Getting the Medicine and Science Together
Invited Speaker
March 2010, Silver Spring MD
Surface Plasmon Resonance Imaging (SPRI) Protein Microarray
6th CNHUPO Annul Meeting
Supporting Technologies for Proteomics
Chairperson
July 2009 Taizhou, Jiangsu, China
Surface Plasmon Resonance Imaging (SPRI) Antibody Array in Biomarker Discovery
International Congress of Antibodies
Invited speaker
May 2009 Beijing China
A Protein Chip for Hepatotoxicity.
World Pharmaceutical Congress 2008
Hepatotoxity and Drug Safety
Invited Speaker
May 2008 Philadelphia PA
Protein chips application in hepatotoxicity and cancer diagnostics.
Life Science Annual Conference 2008
Cancer Prevention and Control
Invited Plenary Speaker
April 2008 Beijing China
A panel of liver specific blood biomarkers.
Preclinical Safety Testing Consortium (PSTC) Annual Meeting
Hepatotoxicity session
Invited speaker
March 2008 Seattle WA
Quantitative Proteomics by Surface Plasmon Resonance Based Antibody Microarrays.
1st. International Conference on Toxicogenomics Integrated with Environmental Sciences
Invited Plenary Speaker
Oct. 2007 Raleigh NC
Selected Serum Proteome Analyses of Drug Induced Liver Injury.
by Surface Plasmon Resonance Antibody Microarray.
US HUPO Third Annual Conference—from genes to function
Plenary Speaker
March 2007 Seattle WA
A Prototype SPR Antibody Microarray for Blood Biomarker Discovery.
NSBCC Annual Retreat
Oral presentation
Feb. 2007 Ventura CA
Role of Malonyl-CoA in the hypothalamic control of food intake.
The Mid-Atlantic Diabetes Research Symposium
Invited Speaker
Sept. 2003 Bethesda MD
Collaboration
Institute for Systems Biology, Seattle, WA
Beijing Proteome Research Center
Beijing Proteome Research Center
Students
已指导学生
马怀雷 博士研究生 070304-物理化学
雷春妮 硕士研究生 071011-生物物理学
郑晖 博士研究生 070304-物理化学
王子华 博士研究生 070304-物理化学
赵子健 博士研究生 070304-物理化学
现指导学生
李仁 博士研究生 070304-物理化学
丛勇 硕士研究生 071011-生物物理学
岳春燕 博士研究生 0703J1-纳米科学与技术
史方浩 硕士研究生 0710J1-纳米科学与技术
贾斐 博士研究生 0703J1-纳米科学与技术
钱怡霞 博士研究生 0703J1-纳米科学与技术
方治国 硕士研究生 085238-生物工程