基本信息

岳华  女  博导(教授)中国科学院过程工程研究所
电子邮件: hyue@ipe.ac.cn
通信地址: 中国科学院过程工程研究所
邮政编码:

研究领域

新型纳微米颗粒在疫苗佐剂和肿瘤免疫中的应用

招生信息

生物材料与药物剂型
招生专业
081703-生物化工
招生方向
生物材料与药物剂型
纳微颗粒制备及应用
疫苗佐剂和肿瘤免疫

教育背景

2008-09--2012-07   中国科学院过程工程研究所   工学博士
2005-09--2008-07   山东大学微生物国家重点实验室   理学硕士

工作经历

   
工作简历
2024-10~现在, 中国科学院过程工程研究所, 项目研究员
2021-01~2024-10,中国科学院过程工程研究所, 青年研究员
2015-07~2021-01,中国科学院过程工程研究所, 副研究员
2012-07~2015-07,中国科学院过程工程研究所, 助理研究员
社会兼职
2025-01-04-2026-11-30,中国颗粒学会青年理事,
2022-03-01-今,Top editor of Frontiers in Bioengineering and Biotechnology,
2015-01-01-2015-12-31,中国科学院过程工程研究所青年创新促进会, 主席
2013-01-01-今,中国科学院青年创新促进会, 会员

出版信息

   
发表论文
(1) SudokuFill: AMulti-Agent Progressive Filling Framework for Document-Level Scientific Information Extraction, Findings of the Association for Computational Linguistics: ACL 2026, 2026, 
(2) Engineered Polylactic Acid (PLA) Microcapsules for Spatiotemporally Coupled Delivery and Synergistically Enhanced Dual Immunity, Pharmaceutics, 2026, 
(3) Regional immunity in the respiratory tract: challenges and opportunities, Science Bulletin, 2026, 第 1 作者
(4) AN OPEN-ENDED BENCHMARK AND FORMAL FRAME WORK FOR ADJUVANT RESEARCH WITH MLLMS, ICLR 2026, 2026, 
(5) 基于离子液体的靶向Bcl-2小干扰RNA递送系统治疗黑色素瘤, An ionic liquid-based delivery system of small interfering RNA targeting Bcl-2 for melanoma therapy, Biomaterials Science, 2025, 第 5 作者  通讯作者
(6) 疫苗颗粒佐剂, Particle adjuvants for vaccines, 科学通报, 2025, 第 3 作者
(7) Exploring the immunological impact of particles across dimensions in antigen and drug delivery systems, Frontiers of Chemical Science and Engineering , 2025, 第 1 作者  通讯作者
(8) 多孔PLGA微球作为新型冠状病毒疫苗佐剂的研究, Porous PLGA microsphere as a vaccine adjuvant against COVID-19, 过程工程学报, 2024, 第 3 作者
(9) Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment, JOURNAL OF NANOBIOTECHNOLOGY, 2024, 第 3 作者  通讯作者
(10) A two-pronged strategy utilizing exosomes extracted from antigen presenting cells to combat hepatitis B, Nano Research, 2024, 
(11) An ionic liquid-based delivery system of small interfering RNA targeting Bcl-2 for melanoma therapy, Biomaterials Science, 2024, 第 5 作者  通讯作者
(12) 疫苗颗粒佐剂, Particle adjuvants for vaccines, 科学通报, 2024, 第 3 作者  通讯作者
(13) 用于提高紫杉醇溶解度的生物相容性双咪唑基离子液体体系, Biocompatible diimidazolium based ionic liquid systems for enhancing the solubility of paclitaxel, Green Chemistry, 2024, 第 2 作者
(14) 用于局部靶向药物递送和有效皮肤癌治疗的载有铁蛋白-纳米笼阿霉素的微针贴片, Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment, Particuology, 2024, 第 3 作者
(15) Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment, Journal of Nanobiotechnology, 2024, 
(16) Nanomaterial's interfacial stimulation of vascular endothelial cells and divergent guidances for nanomedicine treating vasculature-associated diseases, NANO TODAY, 2023, 第 6 作者
(17) Lentinan-laden microspheres reprogram the tumor microenvironment and improve anti-PD-L1 efficacy, Journal of Materials Chemistry B, 2023, 第 3 作者  通讯作者
(18) 离子液体革新生物医学:最新进展和新机遇, Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities, Chem. Soc. Rev., 2023, 第 3 作者
(19) Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities, Chemical Society Reviews, 2023, 第 1 作者
(20) Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization, Nature, 2023, 第 20 作者
(21) 多囊脂质体研究进展, Research process of multivesicular liposomes, 过程工程学报, 2023, 第 2 作者
(22) Construction of gigantic highly-porous microcarriers as a three-dimensional cell culture platform, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2023, 第 5 作者  通讯作者
(23) Advancement of Engineered Bacteria for Orally Delivered Therapeutics, SMALL, 2023, 第 3 作者
(24) Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities, Chemical Society Reviews, 2023, 第 3 作者
(25) PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling, NANO TODAY, 2022, 第 7 作者
(26) Construction of gastric cancer patient-derived organoids and their utilization in a comparative study of clinically used paclitaxel nanoformulations, JOURNAL OF NANOBIOTECHNOLOGY, 2022, 第 4 作者
(27) Advances in Delivering Oxidative Modulators for Disease Therapy, RESEARCH, 2022, 第 2 作者
(28) Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects, NATURE NANOTECHNOLOGY, 2021, 第 14 作者
(29) Prophylactic vaccine delivery systems against epidemic infectious diseases, ADVANCED DRUG DELIVERY REVIEWS, 2021, 第 2 作者
(30) Hydroxypropyltrimethyl ammonium chloride chitosan-based hydrogel as the split H5N1 mucosal adjuvant: Structure-activity relationship, CARBOHYDRATE POLYMERS, 2021, 第 4 作者
(31) Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect, ACTA CHIMICA SINICA, 2021, 第 1 作者
(32) 基于石墨烯独特生物界面效应的功能化载体研究进展, Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect, 化学学报, 2021, 第 1 作者
(33) The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B, JOURNAL OF CONTROLLED RELEASE, 2020, 第 3 作者
(34) Advances in Uniform Polymer Microspheres and Microcapsules:Preparation and Biomedical Applications, Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications, CHINESE JOURNAL OF CHEMISTRY, 2020, 第 2 作者
(35) Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy, ADVANCED MATERIALS, 2020, 第 8 作者
(36) 高分子纳微球在工程疫苗中的新应用, Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines, 高分子学报, 2020, 第 1 作者
(37) Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy, ADVANCED SCIENCE, 2020, 第 10 作者
(38) In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 第 3 作者
(39) Cytosolic delivery of HBsAg and enhanced cellular immunity by pH-responsive liposome, JOURNAL OF CONTROLLED RELEASE, 2020, 第 2 作者
(40) Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines, ACTA POLYMERICA SINICA, 2020, 第 1 作者
(41) Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination, ADVANCED MATERIALS, 2020, 第 6 作者
(42) A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 第 4 作者
(43) Packaging and delivering enzymes by amorphous metal-organic frameworks, NATURE COMMUNICATIONS, 2019, 第 2 作者
(44) Biochemical engineering in China, REVIEWS IN CHEMICAL ENGINEERING, 2019, 第 8 作者
(45) Transport of a graphene nanosheet sandwiched inside cell membranes, SCIENCE ADVANCES, 2019, 第 2 作者
(46) Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine, SMALL, 2018, 第 3 作者
(47) The interacting role of physical stiffness and tumor cells on the macrophages polarization, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 2 作者
(48) Macrophage responses to the physical burden of cell-sized particles, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 第 1 作者
(49) Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination, Nature Materials, 2018, 第 10 作者
(50) PEGylated graphene oxide elicits strong immunological responses despite surface passivation, NATURE COMMUNICATIONS, 2017, 第 5 作者
(51) Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer, ADVANCED SCIENCE, 2017, 第 4 作者
(52) 壳聚糖季铵盐微球作为注射疫苗佐剂的安全性评价, 2016年全国高分子材料科学与工程研讨会论文摘要集, 2016, 第 3 作者
(53) Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2016, 第 4 作者
(54) Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells, ADVANCED MATERIALS, 2016, 第 9 作者
(55) 壳聚糖季铵盐微球作为注射疫苗佐剂的安全性评价, Security Evaluation of N-(2-Hydroxy)propyl-3-trimethylammonium Chitosan Chloride Microspheres as Parenteral Vaccine Adjuvant, 过程工程学报, 2016, 
(56) Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases, JOURNAL OF MATERIALS CHEMISTRY B, 2016, 第 5 作者
(57) Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales, ADVANCED HEALTHCARE MATERIALS, 2016, 第 4 作者
(58) Improving adjuvanticity of quaternized chitosan–based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 第 4 作者
(59) Exploration of graphene oxide as an intelligent platform for cancer vaccines, NANOSCALE, 2015, 第 1 作者
(60) Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages, ACS APPLIED MATERIALS & INTERFACES, 2015, 第 3 作者
(61) Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane, NANOSCALE, 2015, 第 6 作者
(62) Exploration of Graphene Oxide as Intelligent Platform for Cancer Vaccine, Nanoscale, 2015, 
(63) Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications, VACCINE, 2015, 第 1 作者
(64) 基于纳微米颗粒和凝胶佐剂的新型疫苗传递体系, The Development of Micro/Nano Particles and Hydrogel Based Vaccine Delivery System, 中国材料进展, 2015, 第 1 作者
(65) Superior Intratumoral Penetration of Paclitaxel Nanodots Strengthens Tumor Restriction and Metastasis Prevention, SMALL, 2015, 第 4 作者
(66) Construction of Stable Chainlike Au Nanostructures via Silica Coating and Exploration for Potential Photothermal Therapy, SMALL, 2014, 第 4 作者
(67) 纳米载体的理化性质对细胞学效应及抗肿瘤效果的影响, 癌症进展, 2014, 第 6 作者
(68) Porous quaternized chitosan nanoparticles improve the therapeutic effect of paclitaxel on non-small cell lung cancer following oral administration, Biomacromolecules, 2013, 第 1 作者
(69) Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression, BIOMATERIALS, 2013, 第 7 作者
(70) Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs, JOURNAL OF MATERIALS CHEMISTRY B, 2013, 第 5 作者
(71) Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy, BIOMATERIALS, 2013, 第 3 作者
(72) Inducible graphene oxide probe for high-specific tumor diagnosis, CHEMICAL COMMUNICATIONS, 2013, 第 3 作者
(73) The orchestration of cellular and humoral responses is facilitated by divergent intracellular antigen trafficking in nanoparticle-based therapeutic vaccine, PHARMACOLOGICAL RESEARCH, 2012, 第 1 作者
(74) Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD), MOLECULAR PHARMACEUTICS, 2012, 第 4 作者
(75) The role of the lateral dimension of graphene oxide in the regulation of cellular responses, BIOMATERIALS, 2012, 第 1 作者
(76) Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 4 作者
(77) Surface charge affects cellular uptake and intracellular trafficking of chitosan-based nanoparticles., BIOMACROMOLECULES, 2011, 第 4 作者
(78) Porous quaternized chitosan nanoparticles containing paclitaxel nanocrystals improved therapeutic efficacy in non-small-cell lung cancer after oral administration., BIOMACROMOLECULES, 2011, 第 3 作者
(79) Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs, ADVANCED FUNCTIONAL MATERIALS, 2011, 第 5 作者
(80) Particle size affects the cellular response in macrophages, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 第 1 作者
(81) Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation, NANOMEDICINE, 2010, 第 4 作者
(82) Construction of gigantic highly-porous microcarriers as a three-dimensional cell culture platform, COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 第 5 作者  通讯作者
发表著作
(1) New Microsphere and Microcapsule Materials in Biotechnology: design, preparation and application (Microsphere for targeting delivery of anticancer drug, Pan Stanford Publishing Pte Ltd, 2013-05, 第 4 作者