
Jiajia Guo, PhD
Email: jiajia.guo@siat.ac.cn
Shenzhen Institute of Advanced Technology
Chinese Academy of Sciences
Research Areas
Education
09/2015-08/2019 Ph.D. in Nanobiophotonics, University Paris-Sud, France
09/2012-06/2015 MSc in Food Science, Jilin University, China
09/2008-07/2012 B.E. in Food Quality and Safety, Jilin University, China
Experience
10/2019-09/2021 Postdoc Associate, MIT
10/2021-now Associate Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Science
Publications
1. Jiajia Guo, Xuyan Chen, Premashis Manna, Xingcheng Lin, Madelyn N. Scott, Wei Jia Chen, Mikaila Hoffman, Bin Zhang, and Gabriela S. Schlau-Cohen. "Single-molecule acceptor rise time (smART) FRET for nanoscale distance sensitivity." bioRxiv (2023): 2023-03.
2. Shashi Bhuckory, Satu Lahtinen, Niina Höysniemi, Jiajia Guo, Xue Qiu, Tero Soukka, and Niko Hildebrandt. "Understanding FRET in upconversion nanoparticle nucleic acid biosensors." Nano Letters 23, no. 6 (2023): 2253-2261.
3. Chi Chen, Xingfei Wei, Molly F. Parsons, Jiajia Guo, James L. Banal, Yinong Zhao, Madelyn N. Scott, Gabriela S. Schlau-Cohen, Rigoberto Hernandez, Mark Bathe. "Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami." Nature Communications 13, (2022): 4935.
4. Stephanie M. Hart, Xiao Wang, Jiajia Guo, Mark Bathe, and Gabriela S. Schlau-Cohen. "Tuning Optical Absorption and Emission Using Strongly Coupled Dimers in Programmable DNA Scaffolds." The Journal of Physical Chemistry Letters 13, no. 7 (2022): 1863-1871.
5. Li, Ying, Ruifang Su, Hongxia Li, Jiajia Guo, Niko Hildebrandt, and Chunyan Sun. "Fluorescent Aptasensors: Design Strategies and Applications in Analyzing Chemical Contamination of Food." Analytical Chemistry 94, no. 1 (2021): 193-224.
6. Xu, Jingyue, Jiajia Guo, Nicole Golob-Schwarzl, Johannes Haybaeck, Xue Qiu, and Niko Hildebrandt. "Single-Measurement Multiplexed Quantification of MicroRNAs from Human Tissue Using Catalytic Hairpin Assembly and Forster Resonance Energy Transfer." ACS sensors 5, no. 6 (2020): 1768-1776.
7. Jiajia Guo, Carlos Mingoes, Xue Qiu, and Niko Hildebrandt. "Simple, Amplified, and Multiplexed Detection of MicroRNAs Using Time-Gated FRET and Hybridization Chain Reaction." Analytical Chemistry 91, no. 4 (2019): 3101−3109.
8. Jiajia Guo, Xue Qiu, Carlos Mingoes, Jeffrey R. Deschamps, Kimihiro Susumu, Igor L. Medintz, and Niko Hildebrandt. "Conformational Details of Quantum Dot-DNA Resolved by Förster Resonance Energy Transfer Lifetime Nanoruler." ACS Nano 13, no.1 (2018): 505-514.
9. Qiu Xue, Jiajia Guo (co-first author), Jingyue Xu, and Niko Hildebrandt. Three-dimensional FRET multiplexing for DNA quantification with attomolar detection limits. Journal of Physical Chemistry Letters 9, no. 15 (2018): 4379-4384.
10. Qiu Xue, Jingyue Xu, Jiajia Guo, Akram Yahia-Ammar, Nikiforos-Ioannis Kapetanakis, Isabelle Duroux-Richard, Julia J. Unterluggauer et al. Advanced microRNA-based cancer diagnostics using amplified time-gated FRET. Chemical Science 9, no. 42 (2018): 8046-8055.
11. Qiu Xue, Jiajia Guo, Zongwen Jin, Alexandra Petreto, Igor L. Medintz, and Niko Hildebrandt. Multiplexed nucleic acid hybridization assays using single-FRET-pair distance-tuning. Small 13, no. 25 (2017): 1700332.
12. Zheng, Hongru, Ying Li, Jingyue Xu, Jiaxin Bie, Xin Liu, Jiajia Guo, Yeli Luo, Fei Shen, Chunyan Sun, and Yali Yu. "Highly sensitive aptamer-based colorimetric detection of melamine in raw milk with cysteamine-stabilized gold nanoparticles." Journal of Nanoscience and Nanotechnology 17, no. 2 (2017): 853-861.
13. Jiajia Guo, Ying Li, Luokai Wang, Jingyue Xu, Yanjun Huang, Yeli Luo, Fei Shen, Chunyan Sun, and Rizeng Meng. Aptamer-based fluorescent screening assay for acetamiprid via inner filter effect of gold nanoparticles on the fluorescence of CdTe quantum dots. Analytical and bioanalytical chemistry 408, no. 2 (2016): 557-566.
14. Li, Ying, Jingyue Xu, Luokai Wang, Yanjun Huang, Jiajia Guo, Xianyi Cao, Fei Shen, Yeli Luo, and Chunyan Sun. "Aptamer-based fluorescent detection of bisphenol A using nonconjugated gold nanoparticles and CdTe quantum dots." Sensors and Actuators B: Chemical 222 (2016): 815-822.
15. Li, Ying, Jingyue Xu, Minmin Jia, Zekun Yang, Ziwei Liang, Jiajia Guo, Yeli Luo, Fei Shen, and Chunyan Sun. "Colorimetric determination of 17β-estradiol based on the specific recognition of aptamer and the salt-induced aggregation of gold nanoparticles." Materials Letters 159 (2015): 221-224.
16. Xu, Jingyue, Ying Li, Jiaxin Bie, Wei Jiang, Jiajia Guo, Yeli Luo, Fei Shen, and Chunyan Sun. "Colorimetric method for determination of bisphenol A based on aptamer-mediated aggregation of positively charged gold nanoparticles." Microchimica Acta 182, no. 13-14 (2015): 2131-2138.
17. Luo, Yeli, Jingyue Xu, Ying Li, Hanting Gao, Jiajia Guo, Fei Shen, and Chunyan Sun. "A novel colorimetric aptasensor using cysteamine-stabilized gold nanoparticles as probe for rapid and specific detection of tetracycline in raw milk." Food Control 54 (2015): 7-15.
18. Cao, Xianyi, Fei Shen, Minwei Zhang, Jiajia Guo, Yeli Luo, Jingyue Xu, Ying Li, and Chunyan Sun. "Highly sensitive detection of melamine based on fluorescence resonance energy transfer between rhodamine B and gold nanoparticles." Dyes and Pigments 111 (2014): 99-107.
19. Xu, Jingyue, Ying Li, Jiajia Guo, Fei Shen, Yeli Luo, and Chunyan Sun. "Fluorescent detection of clenbuterol using fluorophore functionalized gold nanoparticles based on fluorescence resonance energy transfer." Food Control 46 (2014): 67-74.
20. Jiajia Guo, Xin Liu, Hanting Gao, Jiaxin Bie, Yan Zhang, Baofeng Liu, and Chunyan Sun. Highly sensitive turn-on fluorescent detection of cartap via a nonconjugated gold nanoparticle-quantum dot pair mediated by inner filter effect. RSC Advances 4, no. 52 (2014): 27228-27235.
21. Jiajia Guo, Yan Zhang, Yeli Luo, Fei Shen, and Chunyan Sun. Efficient fluorescence resonance energy transfer between oppositely charged CdTe quantum dots and gold nanoparticles for turn-on fluorescence detection of glyphosate. Talanta 125 (2014): 385-392.
22. Jiajia Guo, Hongkun Li, Meng Xue, Minwei Zhang, Xianyi Cao, Yeli Luo, Fei Shen, and Chunyan Sun. Highly sensitive detection of organophosphorus pesticides represented by methamidophos via inner filter effect of Au nanoparticles on the fluorescence of CdTe quantum dots. Food Analytical Methods 7, no. 6 (2014): 1247-1255.
23. Cao, Xianyi, Fei Shen, Minwei Zhang, Jiaxin Bie, Xin Liu, Yeli Luo, Jiajia Guo, and Chunyan Sun. "Facile synthesis of chitosan-capped ZnS quantum dots as an eco-friendly fluorescence sensor for rapid determination of bisphenol A in water and plastic samples." RSC Advances 4, no. 32 (2014): 16597-16606.
24. Cao, Xianyi, Fei Shen, Minwei Zhang, Jiajia Guo, Yeli Luo, Xing Li, Han Liu, Chunyan Sun, and Jingbo Liu. "Efficient inner filter effect of gold nanoparticles on the fluorescence of CdS quantum dots for sensitive detection of melamine in raw milk." Food Control 34, no. 1 (2013): 221-229.
25. Jiajia Guo, Yeli Luo, Hongkun Li, Xin Liu, Jiaxin Bie, Minwei Zhang, Xianyi Cao, Fei Shen, Chunyan Sun, and Jingbo Liu. Sensitive fluorescent detection of carbamate pesticides represented by methomyl based on the inner filter effect of Au nanoparticles on the fluorescence of CdTe quantum dots. Analytical Methods 5, no. 23 (2013): 6830-6838.
26. Zhang, Minwei, Xianyi Cao, Hongkun Li, Fengrui Guan, Jiajia Guo, Fei Shen, Yeli Luo, Chunyan Sun, and Ligong Zhang. "Sensitive fluorescent detection of melamine in raw milk based on the inner filter effect of Au nanoparticles on the fluorescence of CdTe quantum dots." Food chemistry 135, no. 3 (2012): 1894-1900.
27. Sun, Chun-Yan, Min-Wei Zhang, Hong-Kun Li, Yan-Song Li, Hong Ping, Jia-Jia Guo, and Tie-Hua Zhang. "Gold nanoparticles-based colorimetric sensing of melamine in milk and eggs." Chin J Anal Chem 3 (2012): 386-390.
28. Li, Hongkun, Jiajia Guo (co-first-author), Hong Ping, Lurui Liu, Minwei Zhang, Fengrui Guan, Chunyan Sun, and Qian Zhang. Visual detection of organophosphorus pesticides represented by mathamidophos using Au nanoparticles as colorimetric probe. Talanta 87 (2011): 93-99. 236.
29. Li, Hong-kun, Hong PING, Min-wei ZHANG, Jia-jia Guo, and Chun-yan SUN. "Determination of trace elements in tea by flame atomic absorption spectrometry [J]." Food Science and Technology 3 (2011).Research Interests
1. Nano biosensor
2. Single-molecular Fluorescence Techniques
3. Biophysics
4. Protein interaction
5. Biomarker detection
6. Diagnostics
7. (sm)FRET
8. FCS
9. FLIM
Conferences
1. Jiajia Guo, Multiplexed FRET biosensing for precision diagnostics. 2023 Biphotonic Conference.Shanghai, China, 2023 (oral)
2. Jiajia Guo, Time-resolved Multiplexed Förster Resonance Energy Transfer for Nucleic Acid Biosensing. ACS Fall 2022, Chicago, USA, 2022 (oral)
3. Jiajia Guo, et al. Temporal multiplexing FRET: using single Tb-to-quantum dot pair distance-tuning. SPIE Photonics West, San Francisco, USA, 2019 (invited)
4. Jiajia Guo, et al. Temporal multiplexing of microRNA detection using Tb-dye FRET and amplifications. 10th International Conference on f-Elements (ICFE-10), Lausanne, Switzerland, 2018 (invited)
5. Jiajia Guo, et al. Multiplexed Nucleic Acid Hybridization Assays Using Single Tb-to-Quantum Dot FRET Pair Distance-Tuning. 15th Conference on Methods and Applications in Fluorescence (MAF 15). Bruges, Belgium, 2017 (poster)
6. Jiajia Guo, et al. Lifetime-multiplexed microRNA detection based on distance-dependent FRET from Terbium-Quantum Dot. Fluorescent Biomolecules and Their Building Blocks. Tianjin, China, 2016 (oral)
7. Jiajia Guo, et al. One Quantum Dot Based Time-Gated Förster Resonance Energy Transfer for MicroRNA Duplexing. Förster resonance energy transfer in life sciences. Göttingen, Germany, 2016 (poster)