基本信息
刘凯  男    中国科学院深圳先进技术研究院
电子邮件: k.liu@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

类生命自组装体系的构筑以及其在生物医药、智能材料、催化等领域中的应用

招生信息

   
招生专业
0703Z1-化学生物学
085600-材料与化工
086000-生物与医药
招生方向
生物分子组装功能系统
智能药物与精准治疗
非平衡活性材料

教育背景

2012-09--2017-07   中国科学院过程工程研究所   博士
2008-09--2012-07   燕山大学   学士

工作经历

   
工作简历
2023-05~现在, 中国科学院深圳先进技术研究院, 研究员
2018-06~2023-02,荷兰格罗宁根大学, 博士后

专利与奖励

   
奖励信息
(1) 中国科学院优秀博士论文, 院级, 2018
(2) 中国科学院院长奖, 院级, 2017
(3) 过程工程研究所所长特别奖学金, 研究所(学校), 2017
(4) 过程工程研究所所长奖学金, 研究所(学校), 2016
(5) 宝钢优秀学生奖, 院级, 2016
(6) 朱李月华奖学金, 院级, 2016
(7) 国家奖学金, 国家级, 2016
专利成果
( 1 ) 一种光敏剂纳米粒及其制备方法和用途, 专利授权, 2015, 第 3 作者, 专利号: CN104984340A

出版信息

   
发表论文
[1] Nature Chemistynull. 2024, [2] chemrxivnull. 2023, [3] Liu, Bin, Wu, Juntian, Geerts, Marc, Markovitch, Omer, Pappas, Charalampos G, Liu, Kai, Otto, Sijbren. Out-of-Equilibrium Self-Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(18): https://www.doi.org/10.1002/anie.202117605.
[4] Zhang, Han, Liu, Kai, Gong, Yimou, Zhu, Wenjun, Zhu, Jiafei, Pan, Feng, Chao, Yu, Xiao, Zhishen, Liu, Yanbin, Wang, Xianwen, Liu, Zhuang, Yang, Yang, Chen, Qian. Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy. BIOMATERIALS[J]. 2022, 287: http://dx.doi.org/10.1016/j.biomaterials.2022.121673.
[5] Liu, Bin, Beatty, Meagan A, Pappas, Charalampos G, Liu, Kai, Ottele, Jim, Otto, Sijbren. Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(24): 13569-13573, https://www.doi.org/10.1002/anie.202101052.
[6] Yang, Shuo, Schaeffer, Gael, Mattia, Elio, Markovitch, Omer, Liu, Kai, Hussain, Andreas S, Ottele, Jim, Sood, Ankush, Otto, Sijbren. Chemical Fueling Enables Molecular Complexification of Self-Replicators**. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(20): 11344-11349, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251556/.
[7] Pappas, Charalampos G, Mandal, Pradeep K, Liu, Bin, Kauffmann, Brice, Miao, Xiaoming, Komaromy, David, Hoffmann, Waldemar, Manz, Christian, Chang, Rayoon, Liu, Kai, Pagel, Kevin, Huc, Ivan, Otto, Sijbren. Emergence of low-symmetry foldamers from single monomers. NATURE CHEMISTRY[J]. 2020, 12(12): 1180-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000591151100017.
[8] Monreal Santiago, Guillermo, Liu, Kai, Browne, Wesley R, Otto, Sijbren. Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator. NATURE CHEMISTRY[J]. 2020, 12(7): 603-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000543488100008.
[9] Han, Jingjing, Liu, Kai, Chang, Rui, Zhao, Luyang, Yan, Xuehai. Photooxidase-Mimicking Nanovesicles with Superior Photocatalytic Activity and Stability Based on Amphiphilic Amino Acid and Phthalocyanine Co-Assembly. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(7): 2000-2004, http://ir.ipe.ac.cn/handle/122111/27998.
[10] Bian, Kexin, Zhang, Xuwu, Liu, Kai, Yin, Tian, Liu, Huan, Niu, Kang, Cao, Weiwei, Gao, Dawei. Peptide-Directed Hierarchical Mineralized Silver Nanocages for Anti-Tumor Photothermal Therapy. ACS SUSTAINABLE CHEMISTRY & ENGINEERING[J]. 2018, 6(6): 7574-7588, http://ir.ipe.ac.cn/handle/122111/26682.
[11] Xie, Zengchun, Liu, Kai, Ren, Xiaokang, Zhang, Han, Xin, Xia, Zou, Qianli, Yan, Xuehai. Amino-Acid-Mediated Biomimetic Formation of Light-Harvesting Antenna Capable of Hydrogen Evolution. ACS APPLIED BIO MATERIALS[J]. 2018, 1(3): 748-755, [12] Liu, Kai, Ren, Xiaokang, Sun, Jianxuan, Zou, Qianli, Yan, Xuehai. Primitive Photosynthetic Architectures Based on Self-Organization and Chemical Evolution of Amino Acids and Metal Ions. ADVANCED SCIENCE[J]. 2018, 5(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000435765900007.
[13] Zhang, Han, Liu, Kai, Li, Shukun, Xin, Xia, Yuan, Shiling, Ma, Guanghui, Yan, Xuehai. Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy. ACS NANO[J]. 2018, 12(8): 8266-8276, https://www.webofscience.com/wos/woscc/full-record/WOS:000443525600078.
[14] Liu, Kai, Abass, Manzar, Zou, Qianli, Yan, Xuehai. Self-assembly of biomimetic light-harvesting complexes capable of hydrogen evolution. GREEN ENERGY & ENVIRONMENT[J]. 2017, 2(1): 58-63, https://doaj.org/article/a867be3759324af5b1b4bb9c2de9c45e.
[15] Liu, Kai, Zhang, Ruiyun, Li, Yongxin, Jiao, Tifeng, Ding, Dan, Yan, Xuehai. Tunable Aggregation-Induced Emission of Tetraphenylethylene via Short Peptide-Directed Self-Assembly. ADVANCED MATERIALS INTERFACES[J]. 2017, 4(1): 1600183-1-1600183-6, http://ir.ipe.ac.cn/handle/122111/22454.
[16] Kai Liu, Manzar Abass, Qianli Zou, Xuehai Yan. Self-assembly of biomimetic light-harvesting complexes capable of hydrogen evolution. GREEN ENERGY & ENVIRONMENT[J]. 2017, 2(1): 58-63, http://dx.doi.org/10.1016/j.gee.2016.12.005.
[17] Sun, Jiajia, Yendluri, Raghuvara, Liu, Kai, Guo, Ying, Lvov, Yuri, Yan, Xuehai. Enzyme-immobilized clay nanotube-chitosan membranes with sustainable biocatalytic activities. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2017, 19(1): 562-567, http://ir.ipe.ac.cn/handle/122111/21882.
[18] Liu, Kai, Yuan, Chengqian, Zou, Qianli, Xie, Zengchun, Yan, Xuehai. Self-Assembled Zinc/Cystine-Based Chloroplast Mimics Capable of Photoenzymatic Reactions for Sustainable Fuel Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(27): 7876-7880, http://dx.doi.org/10.1002/anie.201704678.
[19] Liu, Kai, Zhang, Han, Xing, Ruirui, Zou, Qianli, Yan, Xuehai. Biomimetic Oxygen-Evolving Photobacteria Based on Amino Acid and Porphyrin Hierarchical Self-Organization. ACS NANO[J]. 2017, 11(12): 12840-12848, https://www.webofscience.com/wos/woscc/full-record/WOS:000418990200115.
[20] Liu, Kai, Miao, Shida, Su, Zhiguo, Sun, Lijing, Ma, Guanghui, Zhang, Songping. Castor oil-based waterborne polyurethanes with tunable properties and excellent biocompatibility. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY[J]. 2016, 118(10): 1512-1520, http://ir.ipe.ac.cn/handle/122111/21568.
[21] Zou, Qianli, Liu, Kai, Abbas, Manzar, Yan, Xuehai. Peptide-Modulated Self-Assembly of Chromophores toward Biomimetic Light-Harvesting Nanoarchitectonics. ADVANCED MATERIALS[J]. 2016, 28(6): 1031-1043, http://www.irgrid.ac.cn/handle/1471x/1048132.
[22] Liu, Kai, Su, Zhiguo, Miao, Shida, Ma, Guanghui, Zhang, Songping. Enzymatic waterborne polyurethane towards a robust and environmentally friendly antibiofouling coating. RSC ADVANCES[J]. 2016, 6(38): 31698-31704, http://dx.doi.org/10.1039/c6ra04583a.
[23] Wang, Juan, Liu, Kai, Yan, Linyin, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly. ACS NANO[J]. 2016, 10(2): 2138-2143, http://www.irgrid.ac.cn/handle/1471x/1048129.
[24] Liu, Kai, Xing, Ruirui, Zou, Qianli, Ma, Guanghui, Mohwald, Helmuth, Yan, Xuehai. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(9): 3036-3039, http://www.irgrid.ac.cn/handle/1471x/1048134.
[25] Liu, Kai, Su, Zhiguo, Miao, Shida, Ma, Guanghui, Zhang, Songping. UV-curable enzymatic antibacterial waterborne polyurethane coating. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2016, 113(SEP): 107-113, http://dx.doi.org/10.1016/j.bej.2016.06.004.
[26] Chen, Chengjun, Li, Shukun, Liu, Kai, Ma, Guanghui, Yan, Xuehai. Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy. SMALL[J]. 2016, 12(34): 4719-4725, http://ir.ipe.ac.cn/handle/122111/21338.
[27] Wang, Juan, Shen, Guizhi, Ma, Kai, Jiao, Tifeng, Liu, Kai, Yan, Xuehai. Dipeptide concave nanospheres based on interfacially controlled self-assembly: from crescent to solid. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 18(45): 30926-30930, http://www.irgrid.ac.cn/handle/1471x/1179143.
[28] Li, Yongxin, Yan, Linyin, Liu, Kai, Wang, Juan, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Solvothermally Mediated Self-Assembly of Ultralong Peptide Nanobelts Capable of Optical Waveguiding. SMALL[J]. 2016, 12(19): 2575-2579, http://ir.ipe.ac.cn/handle/122111/21174.
[29] Liu, Kai, Kang, Yu, Ma, Guanghui, Moehwald, Helmuth, Yan, Xuehai. Molecular and mesoscale mechanism for hierarchical self-assembly of dipeptide and porphyrin light-harvesting system. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 18(25): 16738-16747, http://ir.ipe.ac.cn/handle/122111/21173.
[30] Liu, Kai, Xing, Ruirui, Li, Yongxin, Zou, Qianli, Moehwald, Helmuth, Yan, Xuehai. Mimicking Primitive Photobacteria: Sustainable Hydrogen Evolution Based on Peptide-Porphyrin Co-Assemblies with a Self-Mineralized Reaction Center. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(40): 12503-12507, http://ir.ipe.ac.cn/handle/122111/21611.
[31] Wang, Juan, Liu, Kai, Xing, Ruirui, Yan, Xuehai. Peptide self-assembly: thermodynamics and kinetics. CHEMICAL SOCIETY REVIEWS[J]. 2016, 45(20): 5589-5604, http://www.irgrid.ac.cn/handle/1471x/1147489.
[32] Xing, Ruirui, Liu, Kai, Jiao, Tifeng, Zhang, Ning, Ma, Kai, Zhang, Ruiyun, Zou, Qianli, Ma, Guanghui, Yan, Xuehai. An Injectable Self-Assembling Collagen-Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic Therapy. ADVANCED MATERIALS[J]. 2016, 28(19): 3669-3676, http://dx.doi.org/10.1002/adma.201600284.
[33] Chen, Chengjun, Liu, Kai, Li, Junbai, Yan, Xuehai. Functional architectures based on self-assembly of bio-inspired dipeptides: Structure modulation and its photoelectronic applications. ADVANCES IN COLLOID AND INTERFACE SCIENCE[J]. 2015, 225(NOV): 177-193, http://dx.doi.org/10.1016/j.cis.2015.09.001.
[34] Liu K, Zhang SP, Su ZG, Ma GH.. Preparation and characterization of castor oil-based cationic waterborne polyurethane. ADVANCED MATERIALS RESEARCH[J]. 2015, 1090: 3-7, http://www.irgrid.ac.cn/handle/1471x/1048108.
[35] Liu, Kai, Xing, Ruirui, Chen, Chengjun, Shen, Guizhi, Yan, Linyin, Zou, Qianli, Ma, Guanghui, Moehwald, Helmuth, Yan, Xuehai. Peptide-Induced Hierarchical Long-Range Order and Photocatalytic Activity of Porphyrin Assemblies. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(2): 500-505, http://www.irgrid.ac.cn/handle/1471x/944978.
[36] Miao, Shida, Liu, Kai, Wang, Ping, Su, Zhiguo, Zhang, Songping. Preparation and Characterization of Epoxidized Soybean Oil-Based Paper Composite as Potential Water-Resistant Materials. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2015, 132(10): http://www.irgrid.ac.cn/handle/1471x/944994.
[37] 刘凯. Screening of lactic acid bacteria with high activities malolactic enzyme and analysis of indigenous flora in red wine. J. Chem. Pharm. Res[J]. 2014, [38] Wang, LiXin, Liu, Kai, Gao, DaWei, Hao, JiKui. Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice. WORLD JOURNAL OF GASTROENTEROLOGY[J]. 2013, 19(20): 3150-3156, https://www.webofscience.com/wos/woscc/full-record/WOS:000319869200021.
发表著作
(1) Peptide-based supramolecular chemistry, Singapore, 2017-04, 第 2 作者
(2) Dynamic combinatorial chemistry out of equilibrium, Wiley-VCH, 2021-04, 第 1 作者
(3) Emergent catalysis by self-replicating molecule, Wiley-VCH, 2021-12, 第 1 作者

科研活动

   
科研项目
( 1 ) 玛丽居里学者基金(Marie Skłodowska Individual Fellowship), 负责人, 其他, 2019-03--2021-02
( 2 ) 西蒙斯基金生命起源合作项目(Life Sciences-Simons Collaboration on the Origins of Life Fellowship), 负责人, 其他, 2018-06--2019-03
( 3 ) 高级研究项目(ERC Advanced Grant), 参与, 其他, 2017-09--2022-08
( 4 ) 肽调控自组装酞菁光热纳米药物的制备、应用与组装机理研究, 参与, 国家任务, 2018-01--2020-12
( 5 ) 金属离子调控寡肽自组装及其用于光动力治疗的机制研究, 参与, 国家任务, 2018-01--2021-12
参与会议
(1)Evolutionary Dynamics of Macrocyclic Self-Replicators   2022-05-26
(2)Ecological-Evolutionary Dynamics of Synthetic Replicators   2020-12-08
(3)Photocatalytically Enhanced Self-Replication of Peptides   2019-04-22