1.     植物细胞壁合成机理研究：

植物细胞壁组分多样，其合成调控网络也十分复杂。我们将以拟南芥(Arabidopsis thaliana)和作物为研究对象，通过正、反向遗传学的方法解析细胞壁合成的调控网络，以加深人们对细胞壁的认识，同时也为以基因工程手段改造细胞壁提供更多的理论支撑。

2.     植物细胞壁介导的抗逆研究：

细胞壁是植物抵抗逆境胁迫的屏障，但是其并不仅仅只是一个“木头盒子”起被动防御。逆境胁迫时，细胞壁的组分和结构发生变化，这些变化能够被质膜上的受体所感知并启动下游的逆境胁迫响应，从而增加植物对逆境胁迫的适应性。我们将以拟南芥(Arabidopsis thaliana)和作物为研究对象，通过各种生物技术方法解析植物细胞壁介导抗逆的机理。

   

071010-生物化学与分子生物学

植物细胞壁功能基因组学

2010-09--2015-09   浙江大学   博士
2006-09--2010-06   华中农业大学   学士

研究生

博士

   

2023-11~现在, 中国科学院昆明植物研究所, 研究员
2016-10~2023-09,Purdue University, 博士后

2022-06-01-今,Frontiers in Plant Science, Associate Editor
2019-12-01-今,Physiology and Molecular Biology of Plants, Associate Editor

   

[1] Wenyi Wang, Weiwei Zhang, Muhammad Jamil, Jumin Tu, Lei Huang. Molecular and genetic mechanisms of plant architecture regulation. Frontiers in Plant Science[J]. 2024, 第 5 作者  通讯作者  
[2] Lei Huang, Weiwei Zhang, Xiaohui Li, Christopher J Staiger, Chunhua Zhang. Point mutations in the catalytic domain disrupt cellulose synthase (CESA6) vesicle trafficking and protein dynamics. THE PLANT CELL. 2023, 第 1 作者35(7): 2654-2677, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291031/.
[3] Huang, Lei, Li, Xiaohui, Zhang, Chunhua. Endosidin20-1 is more potent than endosidin20 in inhibiting plant cellulose biosynthesis and molecular docking analysis of cellulose biosynthesis inhibitors on modeled cellulose synthase structure. PLANT JOURNAL[J]. 2021, 第 1 作者  通讯作者  106(6): 1605-1624, http://dx.doi.org/10.1111/tpj.15258.
[4] Zhang, Weiwei, Huang, Lei, Zhang, Chunhua, Staiger, Christopher J. Arabidopsis myosin XIK interacts with the exocyst complex to facilitate vesicle tethering during exocytosis. PLANT CELL[J]. 2021, 第 2 作者33(7): 2454-2478, http://dx.doi.org/10.1093/plcell/koab116.
[5] Huang, Lei, Zhang, Chunhua. The Mode of Action of Endosidin20 Differs from That of Other Cellulose Biosynthesis Inhibitors. PLANTANDCELLPHYSIOLOGY[J]. 2020, 第 1 作者61(12): 2139-2152, http://dx.doi.org/10.1093/pcp/pcaa136.
[6] Lei Huang, Xiaohui Li, Weiwei Zhang, Nolan Ung, Nana Liu, Xianglin Yin, Yong Li, Robert E Mcewan, Brian Dilkes, Mingji Dai, Glenn R Hicks, Natasha V Raikhel, Christopher J Staiger, Chunhua Zhang. Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis OPEN. THEPLANTCELL. 2020, 第 1 作者32(7): 2141-2157, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346566/.
[7] Lei Huang, Chunhua Zhang. Endosidin20 does not affect cellulose synthase complex transport from ER to the Golgi. PLANT SIGNALING & BEHAVIOR[J]. 2020, 第 1 作者15(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000546479600001.
[8] Huang, Lei, Li, Xiaohui, Zhang, Chunhua. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. CURRENT OPINION IN PLANT BIOLOGY. 2019, 第 1 作者52: 106-113, http://dx.doi.org/10.1016/j.pbi.2019.07.004.
[9] Huang, Lei, Li, Xiaohui, Li, Yang, Yin, Xianglin, Li, Yong, Wu, Bin, Mo, Huaping, Liao, ChaoJan, Mengiste, Tesfaye, Guo, Wei, Dai, Mingji, Zhang, Chunhua. Endosidin2-14 Targets the Exocyst Complex in Plants and Fungal Pathogens to Inhibit Exocytosis. PLANT PHYSIOLOGY[J]. 2019, 第 1 作者180(3): 1756-1770, https://www.webofscience.com/wos/woscc/full-record/WOS:000473274000039.
[10] Huang, Lei, Hong, Yongbo, Zhang, Huijuan, Li, Dayong, Song, Fengming. Rice NAC transcription factor ONAC095 plays opposite roles in drought and cold stress tolerance. BMC PLANT BIOLOGY[J]. 2016, 第 1 作者16(1): http://dx.doi.org/10.1186/s12870-016-0897-y.
[11] Huang, Lei, Zhang, Huijuan, Hong, Yongbo, Liu, Shixia, Li, Dayong, Song, Fengming. Stress-Responsive Expression, Subcellular Localization and Protein-Protein Interactions of the Rice Metacaspase Family. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2015, 第 1 作者16(7): 16216-16241, http://dx.doi.org/10.3390/ijms160716216.

（1） Plant Vacuolar Trafficking, Springer, 2018-06, 第 其他 作者
（2） Plant Cell Biology, Elsevier, 2020-09, 第 其他 作者
（3） Plant Chemical Genomics, Springer, 2020-11, 第 其他 作者
（4） Plant Chemical Genomics, Springer, 2020-11, 第 其他 作者

   

（ 1 ） 植物细胞壁纤维素合成相关基因发掘与功能研究, 负责人, 中国科学院计划, 2023-11--2028-11
（ 2 ） 植物细胞壁纤维素合成相关基因发掘与功能研究, 负责人, 研究所自主部署, 2023-11--2028-11