基本信息

刘哲益  男    中国科学院大连化学物理研究所
电子邮件: zy_liu@dicp.ac.cn
通信地址: 辽宁省 大连市 旅顺口区 英歌石植物园南侧 中国科学院能源学院 T1楼
邮政编码:116023

研究领域

2011年于浙江工业大学获得学士学位,2017年于中国科学院大连化学物理研究所获得博士学位。长期从事基于色谱-质谱的蛋白质组分离分析新技术、新方法的研究工作。在Cell Chem. Biol., Sci. Bull., CCS Chem., Chem. Sci., Anal. Chem.等学术期刊发表SCI论文50余篇;SCI引用900余次,H-index 16 (Google Scholar)

 

主要研究方向:

1. 紫外光解离-高分辨质谱表征新方法

构建生物分子紫外光解离-高分辨质谱平台,发展生物分子及其复合物的序列、修饰及三维结构的表征方法,实现对重       要生物分子的高精度分析。

2. 结构蛋白质组学新方法开发

发展复杂生物样品的结构蛋白质组学分析方法,实现对蛋白质结构及药物小分子靶蛋白的高通量分析。

3. 自上而下蛋白质组学新方法开发

建立完整蛋白质的高效分级和色谱分离新方法,发展高效质谱解离技术,实现对完整蛋白质的序列和修饰的规模化分析。



招生信息

   
招生专业
070302-分析化学
招生方向
蛋白质组学

教育背景

2011-09--2017-07   中国科学院大连化学物理研究所   理学博士
2007-09--2011-06   浙江工业大学   理学学士

工作经历

   
工作简历
2021-08~现在, 中国科学院大连化学物理研究所, 副研究员
2017-08~2021-07,中国科学院大连化学物理研究所, 助理研究员

专利与奖励

   
专利成果
[1] 肖春雷, 王方军, 郭永杰, 杨学明, 刘哲益. 一种基于二次激光电离技术的离子化装置及方法. CN: CN115188653A, 2022-10-14.
[2] 王方军, 张婷婷, 刘哲益, 罗盼. 一种紫外光诱导苯环或杂环的环上C-H中H卤代的方法. CN: CN114763312A, 2022-07-19.
[3] 王方军, 罗盼, 刘哲益, 肖春雷. 一种芳香族氨基酸卤化修饰的直接光化学方法. CN: CN114763368A, 2022-07-19.
[4] 王方军, 罗盼, 刘哲益, 肖春雷. 一种基于光化学的蛋白质标记方法. CN: CN112876532A, 2021-06-01.
[5] 王方军, 刘哲益. 一种原位产生系列标准金属团簇离子的质谱校正方法. CN: CN111077210A, 2020-04-28.
[6] 王方军, 刘哲益, 肖春雷, 李杲. 一种基于激光解离的裸金属团簇离子的制备方法. CN: CN110967393A, 2020-04-07.
[7] 王方军, 刘哲益, 肖春雷, 李杲. 一种基于质谱的金团簇离子反应活性分析方法. CN: CN110967391A, 2020-04-07.
[8] 王方军, 周烨, 刘哲益. 筛选药物引起结构和相互作用变化蛋白质的质谱分析方法. CN: CN110873766B, 2021-10-15.
[9] 王方军, 孙彬文, 刘哲益. 一种基于疏水性氨基酸特异性蛋白酶的蛋白质分析方法. CN: CN109839469A, 2019-06-04.
[10] 王方军, 刘哲益, 周烨. 一种活性蛋白质与小分子相互作用的质谱检测方法. CN: CN108508125A, 2018-09-07.

出版信息

   
发表论文
[1] Zhou, Lingqiang, Liu, Zheyi, Guo, Yongjie, Liu, Shiwen, Zhao, Heng, Zhao, Shan, Xiao, Chunlei, Feng, Shun, Yang, Xueming, Wang, Fangjun. Ultraviolet Photodissociation Reveals the Molecular Mechanism of Crown Ether Microsolvation Effect on the Gas-Phase Native-like Protein Structure. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 145(2): 1285-1291, http://dx.doi.org/10.1021/jacs.2c11210.
[2] Bai, Yu, Liu, Zheyi, Li, Yuanqing, Zhao, Heng, Lai, Can, Zhao, Shan, Chen, Kaixian, Luo, Cheng, Yang, Xueming, Wang, Fangjun. Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 145(21): 11477-11481, http://dx.doi.org/10.1021/jacs.3c01697.
[3] 王方军, 刘哲益, 殷志斌, 罗盼, 杨诗蕊, 肖春雷, 杨学明. 基于先进紫外光源的生物质谱技术的最新进展及展望. 中国科学. 化学[J]. 2023, 53(11): 2290-2303, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7623583&detailType=1.
[4] Xie, Anqi, Ji, Haihua, Liu, Zheyi, Wan, Yiqun, Zhang, Xuecong, Xiong, Huihuang, Nie, ShaoPing, Wan, Hao. Modified Prebiotic-Based "Shield" Armed Probiotics with Enhanced Resistance of Gastrointestinal Stresses and Prolonged Intestinal Retention for Synergistic Alleviation of Colitis. ACS NANO[J]. 2023, 17(15): 14775-14791, http://dx.doi.org/10.1021/acsnano.3c02914.
[5] Luo, Pan, Liu, Zheyi, Zhang, Tingting, Wang, Xiaolei, Liu, Jing, Liu, Yiqiang, Zhou, Xiaohu, Chen, Yang, Dong, Wenrui, Xiao, Chunlei, Jin, Yan, Yang, Xueming, Wang, Fangjun. Chloride-Mediated Peroxide-Free Photochemical Oxidation of Proteins (PPOP) in Mass Spectrometry-Based Structural Analysis. ANALYTICAL CHEMISTRY[J]. 2022, 94(2): 1135-1142, http://dx.doi.org/10.1021/acs.analchem.1c04209.
[6] Chen, Xiong, Ji, Shanping, Liu, Zheyi, Yuan, Xiao, Xu, Congsheng, Qi, Ruxi, He, An, Zhao, Heng, Song, Haiping, Xiao, Chunlei, Gao, Weina, Chen, Peng R, Luo, Ray, Li, Pengfei, Wang, Fangjun, Yang, Xueming, Tian, Ruijun. Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics. CELL CHEMICAL BIOLOGY[J]. 2022, 29(6): 1024-+, [7] Liu, Zheyi, Qin, Zhaoxian, Cui, Chaonan, Luo, Zhixun, Yang, Bing, Jiang, You, Lai, Can, Wang, Zhipeng, Wang, Xiaolei, Fang, Xiang, Li, Gao, Wang, Fangjun, Xiao, Chunlei, Yang, Xueming. In-situ generation and global property profiling of metal nanoclusters by ultraviolet laser dissociation-mass spectrometry. SCIENCE CHINA-CHEMISTRY[J]. 2022, 65(6): 1196-1203, http://dx.doi.org/10.1007/s11426-022-1267-5.
[8] He, Min, Wang, Wangyin, Liu, Zheyi, Zhang, Wenxiang, Li, Jinan, Tian, Wenming, Zhou, Ye, Jin, Yan, Wang, Fangjun, Li, Can. Characterization and manipulation of the photosystem II-semiconductor interfacial molecular interactions in solar-to-chemical energy conversion. JOURNAL OF ENERGY CHEMISTRY[J]. 2022, 70: 437-443, https://www.sciengine.com/doi/10.1016/j.jechem.2022.03.002.
[9] Zhou, Lingqiang, Liu, Zheyi, Guo, Yongjie, Liu, Shiwen, Zhao, Heng, Zhao, Shan, Xiao, Chunlei, Feng, Shun, Yang, Xueming, Wang, Fangjun. Ultraviolet Photodissociation Reveals the Molecular Mechanism of Crown Ether Microsolvation Effect on the Gas-Phase Native-like Protein Structure. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2022, [10] Sun, Binwen, Lv, Ji, Chen, Jin, Liu, Zheyi, Zhou, Ye, Liu, Lin, Jin, Yan, Wang, Fangjun. Size-Selective VAILase Proteolysis Provides Dynamic Insights into Protein Structures. ANALYTICAL CHEMISTRY[J]. 2021, 93(30): 10653-10660, http://dx.doi.org/10.1021/acs.analchem.1c02042.
[11] Liu, Zheyi, Zhang, Wenxiang, Sun, Binwen, Ma, Yaolu, He, Min, Pan, Yuanjiang, Wang, Fangjun. Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling. CHEMICAL SCIENCE[J]. 2021, 12(4): 1451-1457, http://dx.doi.org/10.1039/d0sc05330a.
[12] Tu, Yunchuan, Tang, Wei, Yu, Liang, Liu, Zheyi, Liu, Yanting, Xia, Huicong, Zhang, Haiwei, Chen, Shiyun, Wu, Jia, Cui, Xiaoju, Zhang, Jianan, Wang, Fangjun, Hu, Yangbo, Deng, Dehui. Inactivating SARS-CoV-2 by electrochemical oxidation. Science Bulletin[J]. 2021, 66(7): 720-726, https://www.sciengine.com/doi/10.1016/j.scib.2020.12.025.
[13] Shao, Yaping, Li, Tianbai, Liu, Zheyi, Wang, Xiaolin, Xu, Xiaojiao, Li, Song, Xu, Guowang, Le, Weidong. Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry. MOLECULAR NEURODEGENERATION[J]. 2021, 16(1): http://dx.doi.org/10.1186/s13024-021-00425-8.
[14] Sun, Binwen, Liu, Zheyi, Fang, Xiang, Wang, Xiaolei, Lai, Can, Liu, Lin, Xiao, Chunlei, Jiang, You, Wang, Fangjun. Improving the performance of proteomic analysis via VAILase cleavage and 193-nm ultraviolet photodissociation. ANALYTICA CHIMICA ACTA[J]. 2021, 1155: http://dx.doi.org/10.1016/j.aca.2021.338340.
[15] Xu, Caiming, Zhang, Jingyu, Liu, Jing, Li, Zhaoxia, Liu, Zheyi, Luo, Yalan, Xu, Qiushi, Wang, Mengfei, Zhang, Guixin, Wang, Fangjun, Chen, Hailong. Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity. JOURNAL OF PROTEOMICS[J]. 2020, 220: http://dx.doi.org/10.1016/j.jprot.2020.103760.
[16] Liu, Zheyi, Li, Zhimin, Li, Guanna, Wang, Zhipeng, Lai, Can, Wang, Xiaolei, Pidko, Evgeny A, Xiao, Chunlei, Wang, Fanjun, Li, Gao, Yang, Xueming. Single-Atom Pt+ Derived from the Laser Dissociation of a Platinum Cluster: Insights into Nonoxidative Alkane Conversion. JOURNAL OF PHYSICAL CHEMISTRY LETTERS[J]. 2020, 11(15): 5987-5991, http://dx.doi.org/10.1021/acs.jpclett.0c01416.
[17] Sun, Binwen, Liu, Zheyi, Fang, Zheng, Dong, Wei, Yu, Yang, Ye, Mingliang, Liu, Lin, Wang, Hongda, Wang, Fangjun. Probing the Proteomics Dark Regions by VAILase Cleavage at Aliphatic Amino Acids. ANALYTICAL CHEMISTRY[J]. 2020, 92(3): 2770-2777, https://www.webofscience.com/wos/woscc/full-record/WOS:000511509400056.
[18] 周烨, 刘哲益, 王方军. 结构蛋白质组学研究进展. 色谱[J]. 2019, 37(8): 788-797, http://lib.cqvip.com/Qikan/Article/Detail?id=7002627630.
[19] Liu, Zheyi, Wang, Ruimin, Liu, Jing, Sun, Ruixiang, Wang, Fangjun. Global Quantification of Intact Proteins via Chemical Isotope Labeling and Mass Spectrometry. JOURNALOFPROTEOMERESEARCH[J]. 2019, 18(5): 2185-2194, http://cas-ir.dicp.ac.cn/handle/321008/165470.
[20] Weng, Guofeng, Sun, Binwen, Liu, Zheyi, Wang, Fangjun, Pan, Yuanjiang. Analysis of oligonucleotides by ion-pair reversed-phase liquid chromatography coupled with positive mode electrospray ionization mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2019, 411(18): 4167-4173, https://www.webofscience.com/wos/woscc/full-record/WOS:000474266400021.
[21] Zheyi Liu, Ye Zhou, Jing Liu, Jin Chen, Albert JR Heck, Fangjun Wang. Reductive methylation labeling, from quantitative to structural proteomics. TRENDS IN ANALYTICAL CHEMISTRY. 2019, 118: 771-778, http://dx.doi.org/10.1016/j.trac.2019.07.009.
[22] Zhou, Ye, Liu, Zheyi, Zhang, Jinbao, Dou, Tongyi, Chen, Jin, Ge, Guangbo, Zhu, Shujia, Wang, Fangjun. Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling. CHEMICAL COMMUNICATIONS[J]. 2019, 55(30): 4311-4314, http://cas-ir.dicp.ac.cn/handle/321008/171907.
[23] Chen, TianRan, Wei, LingHua, Guan, XiaoQing, Huang, Chao, Liu, ZheYi, Wang, FangJun, Hou, Jie, Jin, Qiang, Liu, YiFan, Wen, PeiHao, Zhang, ShuiJun, Ge, GuangBo, Guo, WenZhi. Biflavones from Ginkgo biloba as inhibitors of human thrombin. BIOORGANIC CHEMISTRY[J]. 2019, 92: http://dx.doi.org/10.1016/j.bioorg.2019.103199.
[24] Liu, Zheyi, Zhou, Ye, Liu, Jing, Chen, Jin, Heck, Albert J R, Wang, Fangjun. Reductive methylation labeling, from quantitative to structural proteomics. TRAC-TRENDS IN ANALYTICAL CHEMISTRYnull. 2019, 118: 771-778, http://dx.doi.org/10.1016/j.trac.2019.07.009.
[25] Zheyi Liu, You Jiang, Chunlei Xiao, Xingchuang Xiong, Tao Wang, Jinan Li, Fangjun Wang, Xiang Fang, Xueming Yang. Elucidating the various multi-phosphorylation statuses of protein functional regions by 19B-nm ultraviolet photodissociation. 中国化学快报:英文版[J]. 2018, 29(5): 694-698, http://lib.cqvip.com/Qikan/Article/Detail?id=675219422.
[26] Liu, Zheyi, Jiang, You, Xiao, Chunlei, Xiong, Xingchuang, Wang, Tao, Li, Jinan, Wang, Fangjun, Fang, Xiang, Yang, Xueming. Elucidating the various multi-phosphorylation statuses of protein functional regions by 193-nm ultraviolet photodissociation. CHINESECHEMICALLETTERS[J]. 2018, 29(5): 694-698, http://dx.doi.org/10.1016/j.cclet.2017.10.020.
[27] Wang, Fangjun, Liu, Zheyi, Weng, Guofeng. Profiling the short-lived cationic species generated during catalytic dehydration of short-chain alcohols. COMMUNICATIONS CHEMISTRY[J]. 2018, 1(1): https://doaj.org/article/80e4863d74064756922f0089e580a12f.
[28] Wu, Yue, Chen, Jin, Liu, Zheyi, Wang, Fangjun. Identification of pyridoxal phosphate-modified proteins using mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2018, 32(3): 195-200, http://cas-ir.dicp.ac.cn/handle/321008/168500.
[29] Tian, Lirong, Liu, Zheyi, Wang, Fangjun, Shen, Liangliang, Chen, Jinghua, Chang, Lijing, Zhao, Songhao, Han, Guangye, Wang, Wenda, Kuang, Tingyun, Qin, Xiaochun, Shen, JianRen. Isolation and characterization of PSI-LHCI super-complex and their sub-complexes from a red alga Cyanidioschyzon merolae. PHOTOSYNTHESIS RESEARCH[J]. 2017, 133(1-3): 201-214, http://ir.ibcas.ac.cn/handle/2S10CLM1/15352.
[30] Weng, Guofeng, Liu, Zheyi, Chen, Jin, Wang, Fangjun, Pan, Yuanjiang, Zhang, Yukui. Enhancing the Mass Spectrometry Sensitivity for Oligonucleotide Detection by Organic Vapor Assisted Electrospray. ANALYTICAL CHEMISTRY[J]. 2017, 89(19): 10256-10263, http://cas-ir.dicp.ac.cn/handle/321008/150227.
[31] Liu, Zhongshan, Liu, Jing, Liu, Zheyi, Wang, Hongwei, Ou, Junjie, Ye, Mingliang, Zou, Hanfa. Functionalization of hybrid monolithic columns via thiol-ene click reaction for proteomics analysis. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 1498: 29-36, http://dx.doi.org/10.1016/j.chroma.2017.01.029.
[32] Li, Jinan, Liu, Jing, Liu, Zheyi, Tan, Yuan, Liu, Xiaoyan, Wang, Fangjun. Water-soluble Au nanoclusters for multiplexed mass spectrometry imaging. CHEMICAL COMMUNICATIONS[J]. 2017, 53(94): 12688-12691, http://cas-ir.dicp.ac.cn/handle/321008/169256.
[33] Liu, Jing, Xu, Bo, Liu, Zheyi, Dong, Mingming, Mao, Jiawei, Zhou, Ye, Chen, Jin, Wang, Fangjun, Zou, Hanfa. Specific mixing facilitates the comparative quantification of phosphorylation sites with significant dysregulations. ANALYTICA CHIMICA ACTA[J]. 2017, 950: 129-137, http://dx.doi.org/10.1016/j.aca.2016.10.044.
[34] Liu, Shengju, Peng, Jiaxi, Zhang, Hongyan, Li, Xin, Liu, Zheyi, Kang, Xiaohui, Wu, Minghuo, Wu, Renan. Preparation of organic-silica hybrid monolithic columns via crosslinking of functionalized mesoporous carbon nanoparticles for capillary liquid chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 1498: 64-71, http://dx.doi.org/10.1016/j.chroma.2017.03.067.
[35] Li, Jinan, Liu, Jing, Liu, Zheyi, Tan, Yuan, Liu, Xiaoyan, Wang, Fangjun. Detecting Proteins Glycosylation by a Homogeneous Reaction System with Zwitterionic Gold Nanoclusters. ANALYTICAL CHEMISTRY[J]. 2017, 89(8): 4339-4343, http://cas-ir.dicp.ac.cn/handle/321008/151979.
[36] Chen, Jin, Wang, Fangjun, Liu, Zheyi, Liu, Jing, Zhu, Yixin, Zhang, Yukui, Zou, Hanfa. Electrospray ionization in concentrated acetonitrile vapor improves the performance of mass spectrometry for proteomic analyses. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 1483: 101-109, http://cas-ir.dicp.ac.cn/handle/321008/169684.
[37] Zhou, Ye, Wu, Yue, Yao, Mingdong, Liu, Zheyi, Chen, Jin, Chen, Jun, Tian, Lirong, Han, Guangye, Shen, JianRen, Wang, Fangjun. Probing the Lysine Proximal Microenvironments within Membrane Protein Complexes by Active Dimethyl Labeling and Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2016, 88(24): 12060-12065, http://cas-ir.dicp.ac.cn/handle/321008/151819.
[38] Liu, Zheyi, Wang, Fangjun, Chen, Jin, Zhou, Ye, Zou, Hanfa. Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a competitive substitution strategy. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1461: 35-41, http://cas-ir.dicp.ac.cn/handle/321008/170300.
[39] Zhang, Yi, Peng, Jiaxi, Liu, Zheyi, Zou, Hanfa, Wu, Renan. In Situ and Timed Extraction of Cellular Peptides from Live HeLa Cells by Photo-Switchable Mesoporous Silica Nanocarriers. ANALYTICAL CHEMISTRY[J]. 2016, 88(17): 8380-8384, http://cas-ir.dicp.ac.cn/handle/321008/170230.
[40] Liu, Shengju, Peng, Jiaxi, Liu, Zheyi, Liu, Zhongshan, Zhang, Hongyan, Wu, Renan. One-Pot Approach to Prepare Organo-silica Hybrid Capillary Monolithic Column with Intact Mesoporous Silica Nanoparticle as Building Block. SCIENTIFIC REPORTS[J]. 2016, 6: http://cas-ir.dicp.ac.cn/handle/321008/170000.
[41] Ago, Hideo, Adachi, Hideyuki, Umena, Yasufumi, Tashiro, Takayoshi, Kawakami, Keisuke, Kamiya, Nobuo, Tian, Lirong, Han, Guangye, Kuang, Tingyun, Liu, Zheyi, Wang, Fangjun, Zou, Hanfa, Enami, Isao, Miyano, Masashi, Shen, JianRen. Novel Features of Eukaryotic Photosystem II Revealed by Its Crystal Structure Analysis from a Red Alga. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(11): 5676-5687, http://dx.doi.org/10.1074/jbc.M115.711689.
[42] 周烨, 刘哲益, 王方军, 邹汉法. IDENTIFICATION OF INTACT PROTEINS EXTRACTED WITH A MILD DETERGENT OF N-DODECYL β-D-MALTOSIDE. 31st International Symposium on Microscale Bioseparationnull. 2015, http://cas-ir.dicp.ac.cn/handle/321008/143487.
[43] Li, Jinan, Wang, Fangjun, Liu, Jing, Xiong, Zhichao, Huang, Guang, Wan, Hao, Liu, Zheyi, Cheng, Kai, Zou, Hanfa. Functionalizing with glycopeptide dendrimers significantly enhances the hydrophilicity of the magnetic nanoparticles. CHEMICAL COMMUNICATIONS[J]. 2015, 51(19): 4093-4096, http://cas-ir.dicp.ac.cn/handle/321008/146050.
[44] Dong, Mingming, Bian, Yangyang, Dong, Jing, Wang, Keyun, Liu, Zheyi, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2015, 14(12): 5341-5347, http://dx.doi.org/10.1021/acs.jproteome.5b00830.
[45] 刘静, 王方军, 毛家维, 张章, 刘哲益, 黄光, 程凯, 邹汉法. High-Sensitivity N‑ Glycoproteomic Analysis of Mouse Brain Tissue by Protein Extraction with a Mild Detergent of N‑ Dodecyl β‑ D-Maltoside. ANALYTICAL CHEMISTRY[J]. 2015, 87(1): 2054-, http://cas-ir.dicp.ac.cn/handle/321008/143795.
[46] Chen, Jin, Liu, Zheyi, Wang, Fangjun, Mao, Jiawei, Zhou, Ye, Liu, Jing, Zou, Hanfa, Zhang, Yukui. Enhancing the performance of LC-MS for intact protein analysis by counteracting the signal suppression effects of trifluoroacetic acid during electrospray. CHEMICAL COMMUNICATIONS[J]. 2015, 51(79): 14758-14760, http://159.226.238.44/handle/321008/143704.
[47] Liu, Jing, Wang, Fangjun, Mao, Jiawei, Zhang, Zhang, Liu, Zheyi, Huang, Guang, Cheng, Kai, Zou, Hanfa. High-Sensitivity N-Glycoproteomic Analysis of Mouse Brain Tissue by Protein Extraction with a Mild Detergent of N-Dodecyl beta-D-Maltoside. ANALYTICAL CHEMISTRY[J]. 2015, 87(4): 2054-2057, http://cas-ir.dicp.ac.cn/handle/321008/145932.
[48] Li, Jinan, Wang, Fangjun, Wan, Hao, Liu, Jing, Liu, Zheyi, Cheng, Kai, Zou, Hanfa. Magnetic nanoparticles coated with maltose-functionalized polyethyleneimine for highly efficient enrichment of N-glycopeptides. JOURNAL OF CHROMATOGRAPHY A[J]. 2015, 1425: 213-220, http://dx.doi.org/10.1016/j.chroma.2015.11.044.
[49] 刘芳洁, 叶明亮, 刘忠山, 黄俊峰, 刘哲益, 毛家维, 邹汉法. FAST PHOSPHOPROTEOME ANALYSIS BY POLYPROPYLENE TIPS EMBEDDED WITH PHOSPHATE MONOLITHIC ADSORBENT. 43rd international symposium on high performance liquid phase separations and related techniquesnull. 2015, http://cas-ir.dicp.ac.cn/handle/321008/143426.
[50] Wan, Hao, Zhang, Yi, Liu, Zheyi, Xu, Guiju, Huang, Guang, Ji, Yongsheng, Xiong, Zhichao, Zhang, Quanqing, Dong, Jing, Zhang, Weibing, Zou, Hanfa. Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy. NANOSCALE[J]. 2014, 6(15): 8743-8753, http://www.irgrid.ac.cn/handle/1471x/858845.
[51] Wan, Hao, Li, Jinan, Yu, Wenguang, Liu, Zheyi, Zhang, Quanqing, Zhang, Weibing, Zou, Hanfa. Fabrication of a novel magnetic yolk-shell Fe3O4@mTiO(2)@mSiO(2) nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample. RSC ADVANCES[J]. 2014, 4(86): 45804-45808, http://cas-ir.dicp.ac.cn/handle/321008/144342.
[52] Liu, Zhongshan, Ou, Junjie, Lin, Hui, Liu, Zheyi, Wang, Hongwei, Dong, Jing, Zou, Hanfa. Photoinduced thiol-ene polymerization reaction for fast preparation of macroporous hybrid monoliths and their application in capillary liquid chromatography. CHEMICAL COMMUNICATIONS[J]. 2014, 50(66): 9288-9290, http://dx.doi.org/10.1039/c4cc03451a.
[53] Liu, Zhongshan, Ou, Junjie, Lin, Hui, Wang, Hongwei, Liu, Zheyi, Dong, Jing, Zou, Hanfa. Preparation of Monolithic Polymer Columns with Homogeneous Structure via Photoinitiated Thiol-yne Click Polymerization and Their Application in Separation of Small Molecules. ANALYTICAL CHEMISTRY[J]. 2014, 86(24): 12334-12340, http://dx.doi.org/10.1021/ac503626v.
[54] Liu, Jing, Wang, Fangjun, Zhu, Jun, Mao, Jiawei, Liu, Zheyi, Cheng, Kai, Qin, Hongqiang, Zou, Hanfa. Highly efficient N-glycoproteomic sample preparation by combining C-18 and graphitized carbon adsorbents. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2014, 406(13): 3103-3109, http://cas-ir.dicp.ac.cn/handle/321008/145575.
[55] 郑昊, 毛家维, 潘彦博, 刘忠山, 刘哲益, 叶明亮, 邹汉法. 赖氨酸胍基化对蛋白质组分析的影响. CHINESE JOURNAL OF CHROMATOGRAPHY色谱[J]. 2014, 32(4): 376-, http://cas-ir.dicp.ac.cn/handle/321008/144508.
[56] Deng, Zhenzhen, Ye, Mingliang, Bian, Yangyang, Liu, Zheyi, Liu, Fangjie, Wang, Chunli, Qin, Hongqiang, Zou, Hanfa. Multiplex isotope dimethyl labeling of substrate peptides for high throughput kinase activity assay via quantitative MALDI MS. CHEMICAL COMMUNICATIONS[J]. 2014, 50(90): 13960-13962, http://cas-ir.dicp.ac.cn/handle/321008/144507.
[57] Wu, Yue, Wang, Fangjun, Liu, Zheyi, Qin, Hongqiang, Song, Chunxia, Huang, Junfeng, Bian, Yangyang, Wei, Xiaoluan, Dong, Jing, Zou, Hanfa. Five-plex isotope dimethyl labeling for quantitative proteomics. CHEMICAL COMMUNICATIONS[J]. 2014, 50(14): 1708-1710, http://cas-ir.dicp.ac.cn/handle/321008/143851.
[58] Ji, Yongsheng, Xiong, Zhichao, Huang, Guang, Liu, Jing, Zhang, Zhang, Liu, Zheyi, Ou, Junjie, Ye, Mingliang, Zou, Hanfa. Efficient enrichment of glycopeptides using metal-organic frameworks by hydrophilic interaction chromatography. ANALYST[J]. 2014, 139(19): 4987-4993, http://cas-ir.dicp.ac.cn/handle/321008/144517.
[59] 郑昊, 毛家维, 潘彦博, 刘忠山, 刘哲益, 叶明亮, 邹汉法. 赖氨酸胍基化对蛋白质组分析的影响. 色谱[J]. 2014, 32(4): 376-380, http://lib.cqvip.com/Qikan/Article/Detail?id=49198893.
[60] Liu, Zheyi, Ou, Junjie, Liu, Zhongshan, Liu, Jing, Lin, Hui, Wang, Fangjun, Zou, Hanfa. Separation of intact proteins by using polyhedral oligomeric silsesquioxane based hybrid monolithic capillary columns. JOURNAL OF CHROMATOGRAPHY A[J]. 2013, 1317: 138-147, http://dx.doi.org/10.1016/j.chroma.2013.09.004.
[61] 吴越, 刘静, 张轶, 刘哲益, 王方军, 邹汉法. Variations in proteolytic digestion compromise the accuracy of large-scale proteome quantification. the 5th international symposium on microchemistry and microsystemsnull. 2013, 23-, http://159.226.238.44/handle/321008/120175.
[62] 欧俊杰, 林辉, 刘哲益, 张振宾, 董靖, 邹汉法. 含多面体低聚倍半硅氧烷杂化毛细管整体柱的制备及修饰. 色谱[J]. 2013, 31(4): 322-328, http://lib.cqvip.com/Qikan/Article/Detail?id=45614434.
[63] 刘哲益. 整体蛋白质和多磷酸化修饰蛋白质分析新方法. 

科研活动

   
科研项目
( 1 ) 基于“肺与大肠相表里”理论对急性胰腺炎肺损伤发病的分子机制及清胰汤干预的研究, 参与, 国家任务, 2020-12--2023-11
( 2 ) 从0到1原始创新项目“基于极紫外自由电子激光的生命物质基础分析”, 参与, 中国科学院计划, 2019-09--2024-08
( 3 ) 临港实验室, “求索杰出青年计划”开放课题-基于紫外激光解离质谱和分子动力 学模拟的药物研究新方法, 负责人, 其他任务, 2022-01--2024-12