基本信息
梅辉  男  博导  中国科学院深圳先进技术研究院
电子邮件: hui.mei@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码:

研究领域

核酸化学生物学与合成生物学

招生信息

招生专业
071010-生物化学与分子生物学
0703Z1-化学生物学
招生方向
核酸化学生物学
合成生物学

教育背景

2009-04--2015-02   奥斯纳布吕克大学   博士
2006-09--2008-07   北京大学   硕士
2002-09--2006-07   北京大学   学士

工作经历

   
工作简历
2019-09~现在, 中国科学院深圳先进技术研究院, 副研究员
2018-03~2019-07,斯坦福大学, 博士后
2015-10~2018-02,加州大学尔湾分校, 博士后

出版信息

   
发表论文
[1] Mei, Hui, Wang, Yajun, Yik, Eric J, Chaput, John C. Synthesis and polymerase recognition of a pyrrolocytidineTNAtriphosphate. BIOPOLYMERS[J]. 2021, 112(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000544783300001.
[2] 白艳芬, 聂朋, 熊成鹤, 温骏林, 甘海云, 马晴, 胡政, 李雪飞, 于涛, 黄建东, 梅辉. 以非天然核酸为遗传物质的人工生命构建. 科学通报. 2021, 66(3): 347-355, http://lib.cqvip.com/Qikan/Article/Detail?id=7104239793.
[3] Nie, Peng, Bai, Yanfen, Mei, Hui. Synthetic Life with Alternative Nucleic Acids as Genetic Materials. MOLECULESnull. 2020, 25(15): https://doaj.org/article/cc6cd63fbcef4f78aadb5aa824e5924f.
[4] Mei, Hui, Chaput, John C. Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase. CHEMICAL COMMUNICATIONS[J]. 2018, 54(10): 1237-1240, http://dx.doi.org/10.1039/c7cc09130c.
[5] Mei, Hui, Liao, JenYu, Jimenez, Randi M, Wang, Yajun, Bala, Saikat, McCloskey, Cailen, Switzer, Christopher, Chaput, John C. Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(17): 5706-5713, https://www.webofscience.com/wos/woscc/full-record/WOS:000431600000011.
[6] Mei, Hui, Shi, Changhua, Jimenez, Randi M, Wang, Yajun, Kardouh, Miramar, Chaput, John C. Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. NUCLEIC ACIDS RESEARCH[J]. 2017, 45(10): 5629-5638, https://www.webofscience.com/wos/woscc/full-record/WOS:000402510700018.
[7] Mei, Hui, Ingale, Sachin A, Seela, Frank. 3-Phenyl-5,6,7,8-tetrahydropyrimido4,5-cpyridazin-7-one as nucleobase substitute in DNA: synthesis of the 2 '-deoxyribonucleoside, cyclonucleoside formation, and base pairing in oligonucleotides. TETRAHEDRON[J]. 2015, 71(36): 6170-6175, http://dx.doi.org/10.1016/j.tet.2015.06.092.
[8] Jana, Sunit Kumar, Guo, Xiurong, Mei, Hui, Seela, Frank. Robust silver-mediated imidazolo-dC base pairs in metal DNA: dinuclear silver bridges with exceptional stability in double helices with parallel and antiparallel strand orientation. CHEMICAL COMMUNICATIONS[J]. 2015, 51(97): 17301-17304, https://www.webofscience.com/wos/woscc/full-record/WOS:000366954800024.
[9] Mei Hui. Pyrrolo-dC Metal Base Pairs in the Reverse Watson-Crick Double Helix: Capturing of Silver-Ions, Enhanced Stability of Parallel DNA and Impact of 6-Pyridinyl Residues on Fluorescence and Metal Ion Binding.. Chem. Eur. J.. 2015, [10] Mei Hui. Silver Arrays Inside DNA Duplexes Constructed from Ag+-mediated Pyrrolo-dC – Pyrrolo-dC Base Pairs.. ChemPlusChem. 2014, [11] Mei, Hui, Ingale, Sachin A, Seela, Frank. Imidazolo-dC Metal-Mediated Base Pairs: Purine Nucleosides Capture Two Ag+ Ions and Form a Duplex with the Stability of a Covalent DNA Cross-Link. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2014, 20(49): 16248-16257, https://www.webofscience.com/wos/woscc/full-record/WOS:000345515700029.
[12] Mei Hui. Ag+-mediated DNA Base Pairing: Extraordinary Stable Pyrrolo-dC – Pyrrolo-dC Pairs Binding Two Silver Ions.. J. Org. Chem.. 2013, [13] Mei, Hui, Ingale, Sachin A, Seela, Frank. Pyrene and bis-pyrene DNA nucleobase conjugates: excimer and monomer fluorescence of linear and dendronized cytosine and 7-deazaguanine click adducts. TETRAHEDRON[J]. 2013, 69(23): 4731-4742, http://dx.doi.org/10.1016/j.tet.2013.03.054.
[14] Mei, Hui, Budow, Simone, Seela, Frank. Construction and Assembly of Chimeric DNA: Oligonucleotide Hybrid Molecules Composed of Parallel or Antiparallel Duplexes and Tetrameric i-Motifs. BIOMACROMOLECULES[J]. 2012, 13(12): 4196-4204, https://www.webofscience.com/wos/woscc/full-record/WOS:000312035000035.
发表著作
(1) Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue, Humana Press, 2019-04, 第 1 作者

科研活动

   
科研项目
( 1 ) 非天然碱基在噬菌体中的复制和转录体系构建, 参与, 国家级, 2020-01--2024-12