1、工业酶筛选、设计、改造及催化技术开发

2、细胞工厂构建及精细化学品合成技术开发

3、环境微生物资源挖掘及新污染物的生物治理

081703-生物化工

代谢工程，酶工程，分离工程
环境微生物应用

2007-09--2011-06   中国科学院大学   生物化工专业博士
2004-09--2007-06   河北大学   生物化学与分子生物学专业硕士
2000-09--2004-06   河北大学   生物科学专业硕士

博士

2011年至今，中国科学院过程工程研究所工作

2017-07~2025-05,中国科学院过程工程研究所, 副研究员
2011-08~2017-07,中国科学院过程工程研究所, 助理研究员

（ 1 ） 一种高耐受有机硫的嗜盐硫碱杆菌及其培养方法和在生物脱硫中的应用, [[[", 第 1 作者, 专利号: [[[CN111690575A]]]

（ 2 ） 一种用于体外合成香草醛的4-乙烯愈创木酚加氧酶突变体和 工程菌株及其应用, 发明专利, 2026, 第 1 作者, 专利号: CN 120230728 B

（ 3 ） 一种分离ADP与磷酸盐的纳滤-电渗析耦合装置及其应用, 发明专利, 2025, 第 3 作者, 专利号: CN 119499873 B

（ 4 ） 一种从蝙蝠蛾拟青霉菌丝体中分离纯化虫草素的方法, 发明专利, 2025, 第 3 作者, 专利号: CN 115448965 B

（ 5 ） 一种高产单质硫的嗜盐嗜碱性微氧硫微螺菌及其在生物脱硫中的应用, 发明专利, 2021, 第 1 作者, 专利号: CN111676169B

（ 6 ） 一种可实现菌群分区的生物脱硫活性颗粒及其制备方法和应用, 发明专利, 2021, 第 1 作者, 专利号: CN111760443B

（ 7 ） 一种生物脱硫混合菌系及其应用, 发明专利, 2021, 第 3 作者, 专利号: CN112899193A

（ 8 ） 一种含硫气体脱硫装置系统及方法, 发明专利, 2021, 第 3 作者, 专利号: CN112892202A

（ 9 ） 一种木质纤维素酶解体系中多酶组分吸附行为的分析方法及其应用, 发明专利, 2021, 第 1 作者, 专利号: CN112342268A

（ 10 ） 一种嗜盐嗜碱性硫氧化复合菌剂及其制备方法和在生物脱硫中的应用, 发明专利, 2020, 第 1 作者, 专利号: CN111996134A

（ 11 ） 一种嗜盐嗜碱性硫微螺菌及其培养方法和在生物脱硫中的应用, 发明专利, 2020, 第 1 作者, 专利号: CN111676176A

（ 12 ） 一种生物脱硫系统, 实用新型, 2019, 第 3 作者, 专利号: CN209722067U

（ 13 ） 一种嗜盐嗜碱生物脱硫处理工艺及处理装置, 发明专利, 2019, 第 3 作者, 专利号: CN110240961A

（ 14 ） 一种生物脱硫系统和生物燃气脱硫方法, 发明专利, 2017, 第 3 作者, 专利号: CN106975342A

（ 15 ） 一种重组质粒及其制备方法和应用, 发明专利, 2017, 第 3 作者, 专利号: CN106834332A

（ 16 ） 一种用于发酵生产丙酮酸的培养基及其应用, 发明专利, 2017, 第 1 作者, 专利号: CN106434431A

（ 17 ） 一种高产丙酮酸的大肠杆菌基因工程菌及其构建方法和应用, 专利授权, 2016, 第 1 作者, 专利号: CN106167772A

（ 18 ） 一种用于芬顿反应的负载型固体催化剂及其制备方法, 发明专利, 2016, 第 3 作者, 专利号: CN106040244A

（ 19 ） 一种微生物基因改造方法、用于生产高级脂肪醇、高级脂肪烃的基因工程菌及其应用, 发明专利, 2016, 第 3 作者, 专利号: CN105462905A

（ 20 ） 大肠杆菌基因工程菌及其构建方法和在生产丙酮酸中的应用, 发明专利, 2015, 第 1 作者, 专利号: CN104946576A

（ 21 ） 一株具有异养硝化好氧反硝化功能的盐田盐单胞菌及其应用, 发明专利, 2014, 第 3 作者, 专利号: CN103805529A

（ 22 ） 一种由木质纤维素制备碳微球的方法, 发明专利, 2014, 第 2 作者, 专利号: CN103588190A

（ 23 ） 用于生产己二酸的重组质粒、基因工程菌、其制备方法及用途, 发明专利, 2014, 第 3 作者, 专利号: CN103484490A

（1） Combinatorial Engineering of the Catalytic Pocket and Structural Stability in 4‑Vinylguaiacol Oxygenase for Efficient Vanillin Biosynthesis, Journal of Agricultural and Food Chemistry, 2026, 第 9 作者  通讯作者
（2） A new linear growth theoretical model of protein reversible fouling layer in protein wastewater ultrafiltration: fouling mechanism prediction for different proteins and pressures, Water Research, 2026, 第 2 作者  通讯作者
（3） Efficient separation of HEPES and CO 2 -derived fructose by nanofiltration: Optimizing pH for improved separation and proposing a potential mechanism, SEPARATION AND PURIFICATION TECHNOLOGY, 2025, 第 2 作者  通讯作者
（4） 生物脱硫过程中多硫化物介导的硫循环, Polysulfide-mediated sulfur cycling in biological desulfurization process, 微生物学通报, 2025, 第 7 作者
（5） 有机硫对生物脱硫过程的抑制作用与缓解策略, Organic sulfur inhibition toward efficient biological desulfurization and mitigation strategies, 微生物学通报, 2025, 第 7 作者
（6） New insights into the role of reaction-diffusion behavior in the bio-desulfurization: Relieving thiol-induced inhibition, CHEMICAL ENGINEERING JOURNAL, 2025, 第 10 作者
（7） Dual-pathway engineering enables robust vanillin bioproduction in Pseudomonas putida, Chemical Engineering Journal, 2025, 第 8 作者  通讯作者
（8） Engineering a 4‑Vinylguaiacol Oxygenase for Cofactor-Free, Cell- Free Vanillin Biosynthesis, ACS Sustainable Chemistry & Engineering, 2025, 第 4 作者  通讯作者
（9） Mitigating thiols-induced inhibition in biological desulfurization: Selecting thiols-tolerant sulfur-oxidizing bacteria under haloalkaline conditions, CHEMICAL ENGINEERING JOURNAL, 2024, 第 6 作者
（10） Alleviating the thiols-induced inhibition of bio-sulfur particles and bio-oxidation in the biological desulfurization process under haloalkaline conditions, CHEMICAL ENGINEERING JOURNAL, 2024, 第 6 作者
（11） A single-plasmid-based, easily curable CRISPR/Cas9 system for rapid, iterative genome editing in Pseudomonas putida KT2440, MICROBIAL CELL FACTORIES, 2024, 第 5 作者  通讯作者
（12） Rapid degradation of poly(butylene succinate-co-butylene terephthalate)s by microbial communities at high-temperature, BIOCHEMICAL ENGINEERING JOURNAL, 2024, 第 4 作者  通讯作者
（13） Heterologous expression of sulfur: quinone oxidoreductase (Sqr) to improve Thioalkalivibrio versutus D301 desulfurization performance, JOURNAL OF APPLIED MICROBIOLOGY, 2024, 第 12 作者  通讯作者
（14） A novel bioelectrochemical strategy for efficient treatment of saline-alkaline and oligotrophic sulfate wastewater mediated by bacterial electron shuttling, JOURNAL OF WATER PROCESS ENGINEERING, 2023, 第 11 作者  通讯作者
（15） Biologically produced elemental sulfur clogging induced by thiols in gas biodesulfurization systems, CHEMICAL ENGINEERING JOURNAL, 2023, 第 3 作者
（16） 典型预处理对甘草渣酶解产糖及其结构的影响, Effects of Typical Pretreatments on Sugar Production by Enzymatic Hydrolysis and Structural Changes of Licorice Root Residue, 生物质化学工程, 2023, 第 6 作者
（17） CRISPR/Cas12a-Mediated Genome Editing in Thioalkalivibrio versutus, ACS SYNTHETIC BIOLOGY, 2023, 第 8 作者
（18） Organic layer characteristics and microbial utilization of the biosulfur globules produced by haloalkaliphilic Thioalkalivibrio versutus D301 during biological desulfurization, EXTREMOPHILES, 2022, 第 2 作者  通讯作者
（19） Ribosome-binding Sequences (RBS) Engineering of Key Genes in Escherichia coli for High Production of Fatty Alcohols, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2022, 第 6 作者  通讯作者
（20） Organic layer characteristics and microbial utilization of the biosulfur globules produced by haloalkaliphilic Thioalkalivibrio versutus D301 during biological desulfurization, EXTREMOPHILES, 2022, 第 2 作者  通讯作者
（21） Rate-based model for predicting and evaluating H 2 S absorption in the haloalkaliphilic biological desulfurization process, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2022, 第 4 作者
（22） Composition and key-influencing factors of bacterial communities active in sulfur cycling of soda lake sediments, ARCHIVES OF MICROBIOLOGY, 2022, 第 2 作者  通讯作者
（23） Enhanced Biodesulfurization with a Microbubble Strategy in an Airlift Bioreactor with Haloalkaliphilic Bacterium Thioalkalivibrio versutus D306, ACS OMEGA, 2022, 第 4 作者
（24） 电缆细菌及其介导的生电硫氧化（e-SO_（x））过程研究进展, Advances in the research on cable bacteria and their mediated electrogenic sulfur oxidation(e-SO_(x)), 应用与环境生物学报, 2022, 第 2 作者
（25） The Cradle-to-Cradle Life Cycle Assessment of Polyethylene terephthalate: Environmental Perspective, MOLECULES, 2022, 第 3 作者  通讯作者
（26） Rate-based model for predicting and evaluating H2S absorption in the haloalkaliphilic biological desulfurization process, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2022, 第 4 作者
（27） Ribosome-binding Sequences (RBS) Engineering of Key Genes in Escherichia coli for High Production of Fatty Alcohols, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2022, 第 6 作者  通讯作者
（28） 表面活性剂对嗜盐嗜碱硫碱弧菌D301生成及利用硫颗粒的影响, Effect of surfactants on the formation and metabolism of sulfur particles by Thialkalivibrio versutus D301, 微生物学通报, 2021, 第 2 作者
（29） Improvement of d-lactic acid productivity by introducing Escherichia coli acetyl-CoA synthesis pathway in engineered Saccharomyces cerevisiae, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2021, 第 2 作者
（30） 盐碱湖硫循环及嗜盐嗜碱硫功能菌研究进展, Advances in research on the sulfur cycle and haloalkaliphilic sulfur bacteria in soda lakes, 应用与环境生物学报, 2021, 第 1 作者
（31） Performance and characteristic of a haloalkaliphilic bio-desulfurizing system using Thioalkalivibrio verustus D301 for efficient removal of H2S, BIOCHEMICAL ENGINEERING JOURNAL, 2021, 第 2 作者
（32） Recent advances in microbial capture of hydrogen sulfide from sour gas via sulfur-oxidizing bacteria, ENGINEERING IN LIFE SCIENCES, 2021, 第 8 作者
（33） Solubility of H2S under Haloalkaliphilic Conditions: Experimental Measurement and Modeling with the Electrolyte NRTL Equation, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2021, 第 7 作者
（34） Nano-immobilization of PETase enzyme for enhanced polyethylene terephthalate biodegradation, BIOCHEMICAL ENGINEERING JOURNAL, 2021, 第 8 作者
（35） Revealing sulfate role in empowering the sulfur-oxidizing capacity of Thioalkalivibrio versutus D301 for an enhanced desulfurization process, BIORESOURCE TECHNOLOGY, 2021, 第 4 作者
（36） Improvement of D-lactic acid production at low pH through expressing acid-resistant gene IoGAS1 in engineered Saccharomyces cerevisiae, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2021, 第 2 作者
（37） 中药渣处理及其生命周期分析的研究进展, 时珍国医国药, 2021, 第 2 作者
（38） Transcriptional response of Thialkalivibrio versutus D301 to different sulfur sources and identification of the sulfur oxidation pathways, JOURNAL OF BIOTECHNOLOGY, 2021, 第 2 作者  通讯作者
（39） Solubility of H 2 S under Haloalkaliphilic Conditions: Experimental Measurement and Modeling with the Electrolyte NRTL Equation, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2021, 第 7 作者
（40） Revealing sulfate role in empowering the sulfur-oxidizing capacity of Thioalkalivibrio versutus D301 for an enhanced desulfurization process, BIORESOURCE TECHNOLOGY, 2021, 第 4 作者
（41） 天然气生物脱硫技术研究进展, Advance in biological desulfurization technology of natural gas, 化工进展, 2021, 第 4 作者
（42） 有机硫对生物脱硫过程的抑制机理及其研究进展, Inhibition of biological desulfurization by organosulfur: a review, 生物工程学报, 2021, 第 2 作者
（43） 一株嗜盐嗜碱硫氧化菌的筛选、鉴定及硫氧化特性, Screening, identification and sulfide oxidation characteristics of a haloalkaliphilic sulfur oxidizing bacterium, 微生物学通报, 2020, 第 2 作者
（44） Recent advances in biocatalysts engineering for polyethylene terephthalate plastic waste green recycling, ENVIRONMENT INTERNATIONAL, 2020, 第 5 作者
（45） Deep and high-efficiency removal of sulfate through a coupling system with sulfate-reducing and sulfur-oxidizing capacity under haloalkaliphilic condition, BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2020, 第 2 作者
（46） Succinate Production with Metabolically Engineered Escherichia coli Using Elephant Grass Stalk (Pennisetum purpureum) Hydrolysate as Carbon Source, WASTE AND BIOMASS VALORIZATION, 2020, 第 2 作者
（47） Improving confirmed nanometric sulfur bioproduction using engineered Thioalkalivibrio versutus, BIORESOURCE TECHNOLOGY, 2020, 第 14 作者
（48） Improvement of D-lactic acid production at low pH through expressing acid-resistant gene IoGAS1 in engineered Saccharomyces cerevisiae, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2020, 第 2 作者
（49） Effective production of succinic acid from coconut water (Cocos nucifera) by metabolically engineered Escherichia coli with overexpression of Bacillus subtilis pyruvate carboxylase, BIOTECHNOLOGY REPORTS, 2019, 第 2 作者
（50） Enhanced growth-driven stepwise inducible expression system development in haloalkaliphilic desulfurizing Thioalkalivibrio versutus, BIORESOURCE TECHNOLOGY, 2019, 第 6 作者
（51） Sulfate reduction by a haloalkaliphilic bench-scale sulfate-reducing bioreactor and its bacterial communities at different depths, BIOCHEMICAL ENGINEERING JOURNAL, 2019, 第 3 作者
（52） Efficient rhodamine b degradation using electro-fenton process with pbo2-coated titanium as the anode, ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, 2019, 第 2 作者
（53） Systematically redesigning and optimizing the expression of D-lactate dehydrogenase efficiently produces high-optical-purity D-lactic acid in Saccharomyces cerevisiae, BIOCHEMICAL ENGINEERING JOURNAL, 2019, 第 2 作者
（54） Enhanced production of succinic acid from methanol-organosolv pretreated Strophanthus preussii by recombinant Escherichia coli, BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2018, 第 2 作者
（55） Degradation of Rhodamine B at Neutral pH Using Modified Sponge Iron as a Heterogeneous Electro-Fenton Catalyst, ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, 2018, 第 3 作者
（56） Desulfurization with Thialkalivibrio versutus immobilized on magnetic nanoparticles modified with 3-aminopropyltriethoxysilane, BIOTECHNOLOGY LETTERS, 2017, 第 5 作者
（57） Switch on a more efficient pyruvate synthesis pathway based on transcriptome analysis and metabolic evolution, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2017, 第 1 作者  通讯作者
（58） Improvement of pyruvate production based on regulation of intracellular redox state in engineered Escherichia coli, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017, 第 1 作者  通讯作者
（59） Improvement of desulfurizing activity of haloalkaliphilic Thialkalivibrio versutus SOB306 with the expression of Vitreoscilla hemoglobin gene, BIOTECHNOLOGY LETTERS, 2017, 第 2 作者
（60） Construction of pyruvate producing strain with intact pyruvate dehydrogenase and genome-wide transcription analysis, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2017, 第 1 作者  通讯作者
（61） Improvement of pyruvate production based on regulation of intracellular redox state in engineered Escherichia coli, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017, 第 1 作者  通讯作者
（62） High production of fatty alcohols in Escherichia coli with fatty acid starvation, MICROBIAL CELL FACTORIES, 2016, 第 6 作者
（63） Complete genome sequence of Thialkalivibrio versutus D301 isolated from Soda Lake in northern China, a typical strain with great ability to oxidize sulfide, JOURNAL OF BIOTECHNOLOGY, 2016, 第 3 作者
（64） Effective degradation of rhodamine B by electro-Fenton process, using ferromagnetic nanoparticles loaded on modified graphite felt electrode as reusable catalyst: in neutral pH condition and without external aeration, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2016, 第 6 作者
（65） Efficient degradation of rhodamine B using modified graphite felt gas diffusion electrode by electro-Fenton process, Environmental Science and Pollution Research, 2016, 第 4 作者
（66） Efficient production of succinic acid from Palmaria palmata hydrolysate by metabolically engineered Escherichia coli, BIORESOURCE TECHNOLOGY, 2016, 第 2 作者
（67） Efficient production of succinic acid from macroalgae hydrolysate by metabolically engineered Escherichia coli, BIORESOURCE TECHNOLOGY, 2015, 第 3 作者
（68） 基于能量代谢优化的丁二酸生物合成强化, 中国科学 : 化学, 2015, 第 2 作者
（69） Formation and Characterization of Pseudo-Lignin Microspheres during High-pressure Water Pretreatment, BIORESOURCES, 2015, 第 1 作者
（70） Enhanced sulfate reduction by Citrobacter sp coated with Fe3O4/SiO2 magnetic nanoparticles, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2015, 第 2 作者
（71） Novel membrane-based biotechnological alternative process for succinic acid production and chemical synthesis of bio-based poly (butylene succinate), BIORESOURCE TECHNOLOGY, 2014, 第 5 作者
（72） Construction of reductive pathway in Saccharomyces cerevisiae for effective succinic acid fermentation at low pH value, BIORESOURCE TECHNOLOGY, 2014, 第 5 作者
（73） Enhanced saccharification of lignocellulosic biomass with 1-allyl-3-methylimidazolium chloride (AmimCl) pretreatment, CHINESE CHEMICAL LETTERS, 2014, 第 3 作者
（74） Performance of a haloalkaliphilic bioreactor and bacterial community shifts under different COD/SO42− ratios and hydraulic retention times, JOURNAL OF HAZARDOUS MATERIALS, 2014, 第 5 作者
（75） Analysis of mixtures of fatty acids and fatty alcohols in fermentation broth, JOURNAL OF CHROMATOGRAPHY A, 2014, 第 3 作者
（76） Changes in plant cell-wall structure of corn stover due to hot compressed water pretreatment and enhanced enzymatic hydrolysis, WORLDJOURNALOFMICROBIOLOGYBIOTECHNOLOGY, 2014, 第 2 作者
（77） Performance of a haloalkaliphilic bioreactor under different NO3-/SO42- ratios, BIORESOURCE TECHNOLOGY, 2014, 第 5 作者
（78） Bio-desulfurization and denitrification by anaerobicanoxic process for the treatment of wastewater from flue gas washing, WATER SCIENCE AND TECHNOLOGY, 2013, 第 4 作者
（79） 高效嗜碱好氧反硝化细菌的筛选及其脱硝特性, Isolation and Nitrogen Removal Characteristics of an Efficient Alkalophilic Aerobic Strain Denitrifier, 过程工程学报, 2013, 第 3 作者
（80） 酿酒酵母产苹果酸的还原TCA路径构建及发酵调控, Construction and fermentation control of reductive TCA pathway for malic acid production in Saccharomyces cerevisiae, 生物工程学报, 2013, 第 5 作者
（81） Bio-oil based biorefinery strategy for the production of succinic acid, BIOTECHNOLOGY FOR BIOFUELS, 2013, 第 5 作者
（82） Saccharification of the Pretreated Corn Stover by Microwave Assisted DMSO/AmimCl Co-solvents, ACTA CHIMICA SINICA, 2012, 第 3 作者
（83） Saccharification of the Pretreated Corn Stover by Microwave Assisted DMSO/AmimCl Co-solvents, ACTA CHIMICA SINICA, 2012, 第 3 作者
（84） Efficient production of succinic acid from corn stalk hydrolysates by a recombinant Escherichia coli with ptsG mutation, PROCESS BIOCHEMISTRY, 2011, 第 3 作者
（85） Improvement of cellulose conversion caused by the protection of Tween-80 on the adsorbed cellulase, BIOCHEMICAL ENGINEERING JOURNAL, 2011, 第 1 作者
（86） pH Neutralization while Succinic Acid Adsorption onto Anion-Exchange Resins, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2010, 第 6 作者
（87） High-concentration sugars production from corn stover based on combined pretreatments and fed-batch process, BIORESOURCE TECHNOLOGY, 2010, 第 1 作者
（88） Kinetic evaluation of products inhibition to succinic acid producers Escherichia coli NZN111, AFP111, BL21, and Actinobacillus succinogenes 130Z(T), JOURNAL OF MICROBIOLOGY, 2010, 第 4 作者
（89） Optimizing l-(+)-lactic acid production by thermophile Lactobacillus plantarum As.1.3 using alternative nitrogen sources with response surface method, BIOCHEMICAL ENGINEERING JOURNAL, 2010, 第 2 作者
（90） Deep desulfurization of diesel by integrating adsorption and microbial method, BIOCHEMICAL ENGINEERING JOURNAL, 2009, 第 7 作者

（ 1 ） 地衣芽孢杆菌抑菌成分分离纯化及生物合成技术开发, 负责人, 境内委托项目, 2026-01--2028-12
（ 2 ） 纳豆激酶高效分离纯化技术开发, 负责人, 境内委托项目, 2025-11--2026-05
（ 3 ） 甘露糖和新橙皮苷高效分离纯化技术, 负责人, 境内委托项目, 2024-12--2026-12
（ 4 ） 多能硫碱弧菌(Thioalkalivibrio versutus)D301介导的电缆细菌电 子快速释放模式及路径研究, 负责人, 国家任务, 2024-01--2027-12
（ 5 ） 木质素自然生物降解过程解析与仿生技术建立, 负责人, 国家任务, 2023-12--2028-11
（ 6 ） 原位果糖分离浓缩工艺及装置研发, 负责人, 地方任务, 2021-02--2024-02
（ 7 ） 沼气提纯制备生物天然气技术开发, 负责人, 境内委托项目, 2020-01--2022-12
（ 8 ） 中药固废汽爆定向解构技术, 负责人, 国家任务, 2020-01--2023-12
（ 9 ） 林木资源生物共转化燃料乙醇过程全生命周期评价系统, 负责人, 国家任务, 2019-12--2022-12
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