Professor Nai-Xing Wang, a well-known organic synthetic chemist, was validated as an academician of the Romanian Academy of Technical Sciences in 2022. He serves as a professor and PhD student supervisor at the Institute of Physics and Chemistry of the Chinese Academy of Sciences from 2000 to now. In 1996, he went to the United States for postdoctoral research and received the Robert A. Welch Postdoctoral Fellowship in Rice university in 1998. In 2000, he returned to China and was selected as the "Hundred Talents Program" of the Chinese Academy of Sciences. He has published multiple papers in core Journals of organic chemistry, including Org. Lett.; J. Org. Chem.; Adv. Synth. Catal.; Coordin. Chem. Rev. and Nature, with a total of over 180 papers. A paper published in Eur. J. Org. Chem. (2017, 5821–5851), has been cited 428 times; Org. Lett. 2008, 10, 1179 (cited 92 times by others); Org. Lett. 2008, 10, 1875 (cited 86 times by others); Org. Lett. 2015, 17, 4460 (cited 81 times by others); Org. Lett. 2016, 18, 5986 (cited 63 times by others); Coordin. Chem. Rev. 2012, 256, 938 (cited 72 times by others). He has been granted 12 invention patents. In 2013, he was awarded the Science and Technology Award of the Beijing city government for developing multi-chiral novel coenzyme NAD(P)H model molecules and the synthesis and transfer development of multi-chiral drug Nebivolol.

Professor Nai-Xing Wang's research achievements in synthetic organic chemistry over the past decades have had a significant impact on synthetic organic chemistry, which primarily focused on:

1)Developing the Wang reaction;

2) Synthesizing and studying the properties of novel NADH coenzyme model molecules;

3) Synthesizing chiral drug molecules.

1. Research on new C(sp3)-H bond difunctionalization reactions of styrene derivatives with solvent molecules (Wang reaction)

Professor Nai-Xing Wang has made a series of progress in the C(sp3)-H bond difunctionalization reactions of styrene with alcohols, ketones, nitriles, ethers and thioethers (Wang reaction), which is carried out through a free radical relay process. A lot of articles have been published in core organic chemistry journals, these work have been reviewed and summarized into a Wang's reaction formula (Wang's reaction) in Synthesis (Synthesis 2019,51,4542). Professor Nai-Xing Wang was invited to publish an account article on Synlett (Synlett 2021, 32, 23), systematically summarizing the difunctional reactions of related styrene derivatives with solvent molecules as a Wang reaction by a general formula. In June 2026, Liu et al. provided a detailed and relatively comprehensive review of the main contents of the Wang reaction in an extensive article in RSC Adv. 2026, 16, 31348 (IF 6.1).

Wang reaction could can be summarized as:

Wang summarized the universal reaction mechanism formula of the Wang’s reaction based on the experimental results:

General formula of reaction mechanism for Wang reaction.

2 Synthesis and characteristic study of novel NADH coenzyme model molecules

Wang and co-workers has designed and synthesized the first C3 symmetric novel chiral NADH(Nicotinamide Adenine Diunclotide Hydrogen) model molecule with a special bowl-shaped conformation, this novel C3 symmetric NADH model is capable of fluorescent emission at 455 nm when excited at 390 nm. (Wang: Adv. Synth. Catal. 2009, 351, 3045.)

In 2015, Wang and co-workers designed and synthesized a petal-type chiral NADH model molecule, and researched on the asymmetric reduction and fluorogenic sensing for Fe3+. The research results could provide a new strategy for the design of various NADH models based fluorescent chemosensors.(Wang: Sci. Rep. 2015, 5, 17458-17464.)

Wang's research on NADH completely breaks through the limitations of previous researches in this field, in the past, chemists only used NAD(P)H model molecules for organic reduction, Nai-Xing Wang pioneers a new method for efficiently reducing stable unsaturated bonds using dehydrogenases to catalyze NAD(P)H model molecules. Wang was invited to publish Account articles on NAD(P)H (Synlett 2007, 18, 2785 and Synlett 2017, 28, 402).

3 Synthesis of multi chiral antihypertensive drug with specific effect: Nebivolol and Acebutolol

3.1 Synthesis of Nebivolol

In 2007, Nai-Xing Wang and co-workers synthesized multi chiral specific effect antihypertensive drug Nebivolol with four chiral centers. The traditional method of constructing stereocenters using noble metal complexes as chiral catalysts, which is difficult to industrialize, A new method utilizing natural chiral source mannitol has been developed to synthesize the highly effective antihypertensive drug Nebivolol by Wang, The strategy ingeniously utilizes mannitol to obtain the chiral synthons R-acetone glyceraldehyde acetal. After condensation and cyclization, two intermediate configurations, (S, R) and (R, R), are obtained. The intermediates are bonded to yield the absolute configuration of the stereospecific target product, S,R,R,R-stereoisomer (see Wang’s work in: Synlett 2005, 9, 1465 and Synthesis 2007, 8, 1154). Wang’s strategies can easily construct multiple chiral absolute stereoisomers. The final research results were successfully transferred to Beijing Maijin Biopharmaceutical Company in 2015 and was industrialized (Nai-Xing Wang was awarded the Science and Technology Prize of the People's Government of Beijing Municipality).

The synthetic route of multi chiral specific effect antihypertensive drug Nebivolol is as follows: (Wang: Synthesis 2007, 8, 1154)

3.2 Synthesis of Acebutolol

In 2009, Wang and co-workers synthesized a chiral high-efficiency antihypertensive drug with High Enantioselectivity: Acebutolol, (R)-N-[3-Acetyl-4- (2-Hydroxy-3-Isopropylamino- Propoxy)Phenyl]- Butanamide. Synthetic strategy for chiral specific effect antihypertensive drug Acebutolol is as follows: (Wang: Sci. China Chem. 2009, 52, 1216.)

Nai-Xing Wang's group has made some contributions in the field of sulfur-containing new reagents from 2015 to 2021, four sulfur-containing new reagents were developed. DMSO-I₂ (Adv. Synth. Catal. 2019, 361, 3008.) and DMSO-TsCl (Eur. J. Org. Chem. 2021, 1446.) are excellent sulfur methylation reagents. Na₂S-CH₃CN reagent is a cascade reaction reagent for generating sulfoxides (Curr. Org. Synth. 2016, 13, 651.). Especially the new sulfur-containing reagent Na₂S₂O₄-TBHP (Sci. Rep. 2016, 6, 20163.) discovered by Wang's group on February 2016, it was found that aromatic alcohols can be selectively oxidized to aldehydes by Na₂S₂O₄-TBHP, and Wang's group also researched on the reaction mechanism. In April 14, 2016, China Science Daily reported this discovery. Na₂S₂O₄-TBHP reagent was called as the Wang’s reagent by JECI, 2023, 8, 269, and in 2024, Synth Comm. reviewed on the Wang’s reagent (Synth Comm. 2024, 54, 1785.), and Science and Technology Review (2024, 42, 98.) in China also introduced this Wang’s reagent.

1) In 2013, Beijing Science and Technology Prize, awarded by Beijing City Government

2) In 2004, excellent research paper prize of Chinese Chemical Socity
 
3) In 1998 and 1999, two times I got Robert A. Welch Foundation Postdoctoral Fellowship in Organic Chemistry, Rice University, in 1999, I got Extraordinary Ability Individuals (O-1-VISA) in USA 

4) In 1993, got a special class prize for the excellent PhD thesis in BIT (Beijing Institute of Technology) 

5) In 1992, obtained the all over the China excellent student prize in BIT (Beijing Institute of Technology)

6) Professor Nai-Xing Wang wined Wiley China High Contribution Author Award for 2024

Books

1. Wang, Nai-Xing. Organic Reactions - Reaction of Polynitrides and Some Theoretical Issues (Sixth Edition). Beijing: Chemical Industry Press, 2026，ISBN：978-7-122-47952-5. 

2. Wang, Nai-Xing. Nuclear Magnetic Resonance Spectroscopy—Applications in Organic Chemistry(Fourth Edition), Beijing: Chemical Industry Press, 2021. 

3. Wang, Nai-Xing et al. Bio-Organic Photochemistry, Science Press, 2008. 

4. Wang, Nai-Xing. Total Synthesis of Natural Products(second Edition), Science Press, 2014. 

5.  Nai-Xing Wang, Yalan Xing. Chapter 5: Progress in the Synthesis of Chiral Nitrogen Heterocycles Mainly by Asymmetric [3 + 2] Cycloadditions. Ana Maria M. M. Faisca Phillips Edited, Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. Wiley, 2020. ISBN: 9781119708704 (DOI:10.1002/9781119708841)

6. Wang, Nai-Xing, Zhang Tong, Xing Yalan. Chapter 2: Decarboxylative Oxidative Coupling Reaction (p89-138). Sandes, O. M. Edited The Essential Guide to Lewis Acids, New York: Nova Science publishers, Inc. 2019, ISBN: 978-1-53615-236-4.

Selected published papers

1. Nai-Xing Wang,* Shi Tang, Yu-Qiang Zhou, Dumitra Lucan,* Evan Wu, Yalan Xing.* Direct C–H Functionalization on Heteroaromatic Rings. Org. Biomol. Chem. 2026, 24, 61–79.
2.  Lei-Yang Zhang, Nai-Xing Wang,* Dumitra Lucan,* Julia Nastasi, Yalan Xing* Recent Advances of C-S Coupling Reaction of (Hetero)Arenes by C-H Functionalization. Chem. Rec. 2024, 24, e202400177.
3. Nai-Xing Wang*, Zhan Yan, Lei-Yang Zhang, Dumitra Lucan. Some Fluorine-Containing and Sulfur-Containing Functional New Reagents. Synth. Comm. 2024, 54, 1785-1807
4. Lei-Yang Zhang, Nai-Xing Wang*, Dumitra Lucan, William Cheung, Yalan Xing^*. Recent Advances in Aerobic Oxidative of C-H Bond by Molecular Oxygen Focus on Heterocycles. Chem. Eur. J. 2023, 10.1002/chem.202301700
5. Lei-Yang Zhang, Nai-Xing Wang*, Yue-Hua Wu, Zhan Yan, Xue-Wang Gao, Ke Feng, Bao-Cai Xu* Yalan Xing,* Pei-Jia Wang, Yao Zhang, Le-Le Gao. Copper-Catalyzed Aldehyde Exchanged Amidation. Org. Lett. 2022, 24, 658–662.
6. Lei-Yang Zhang, Nai-Xing Wang*, Zhan Yan, Yue-Hua Wu, Xue-Wang Gao, Ke Feng, Dumitra Lucan, * Yalan Xing, * Efficient Aerobic Oxidative Coupling of Methyl Heteroarenes with Indoles. Chem. Eur. J. 2022, e202202240.
7. Zhan Yan, Nai-Xing Wang,* Lei-Yang Zhang, Yue-Hua Wu, Jian-Li Li,* Meng-Yao She, Xue-Wang Gao, Ke Feng and Yalan Xing*. The C(sp3 )–H Bond Functionalization of Thioethers with Styrenes with Insight into the Mechanism. Org. Biomol. Chem., 2022, 20, 5845–5851
8. Wu, Yue-Hua; Wang, Nai‐Xing; Zhang, Tong; Zhang, Lei‐Yang; Gao, Xue‐Wang; Xu, Bao‐Cai; Xing, Yalan; Chi, Jian-Yi; Rare-Earth Y(OTf)3 Catalyzed Coupling Reaction of Ethers with Azaarenes. Org. Lett. 2019, 21, 7450.
9. Wu, Yue-Hua; Zhang, Lei-Yang; Wang, Nai-Xing; Xing, Yalan, Recent advances in the rare-earth metal triflates-catalyzed organic reactions. Catalysis Reviews, 2022, 64, 679-715.
10. Zhang, Lei‐Yang; Wu, Yue‐Hua; Wang, Nai‐Xing; Gao, Xue‐Wang; Yan, Zhan; Xu, Bao‐Cai; Liu, Ning; Wang, Bo‐Zhou; Xing, Yalan, Methylthiolation for Electron‐Rich Heteroarenes with DMSO‐TsCl. Eur. J. Org. Chem. 2021, 1446.
11. Wang, Nai-Xing; Zhang, Lei-Yang; Wu, Yue-Hua, Xing, Yalan;C(sp3)–H Bond Functionalization of Alcohols, Ketones, Nitriles, Ethers and Amides using tert-Butyl Hydroperoxide as a Radical Initiator. Synlett 2021, 32, 23.
12. Zhang, Tong; Wu, Yue-Hua; Wang, Nai-Xing; Xing, Yalan, Advances in C(sp3)–H Bond Functionalization via Radical Processes. Synthesis 2019, 51, 4531.
13. Yue-Hua Wu, Nai-Xing Wang*, Tong Zhang, Zhan Yan, Bao-Cai Xu*, Joan Inoa, Yalan Xing*. Iodine-Mediated Synthesis of Methylthio-Substituted Catechols from Cyclohexanones. Adv. Synth. Catal. 2019, 361, 3008.
14. Zhan Yan, Nai-Xing Wang,* Xue-Wang Gao, Jian-Li Li,* Yue-Hua Wu, Tong Zhang, Shi-Lu Chen,* Yalan Xing*. A Copper (II) Acetate Mediated Oxidative-Coupling of Styrenes and Ethers Through an Unactivated C(sp3)-H Bond Functionalization. Adv. Synth. Catal. 2019, 361, 1007.
15. Lan, Xing-Wang; Wang, Nai-Xing*; Bai, Cui-Bing; Lan, Cui-Lan; Zhang, Tong; Chen, Shi-Lu; and Xing, Yalan. Unactivated C(sp3)-H Bond Functionalization of Alkyl Nitriles with Vinylarenes and Mechanistic Studies. Org. Lett. 2016, 18, 5986.
16. Bai, Cui-Bing; Wang, Nai-Xing*; Lan, Xing-Wang; Wang, Yan-Jing; Xing, Yalan * Wen, Jia-Long; Gao, Xue-Wang and Zhang, Wei. An unexpected controlled new oxidant: SO4-•. Sci. Rep. 2016, 6, 20163.
17. Bai, Cui-Bing; Wang, Nai-Xing*; Wang, Yan-Jing; Xing, Yalan*; Zhang, Wei; and Lan, Xing-Wang. A petal-type chiral NADH model: design, synthesis and its asymmetric reduction. Sci. Rep. 2015, 5, 17458.
18. Zhang, Wei; Wang, Nai-Xing*; Bai, Cui-Bing; Wang, Yan-Jing; Lan, Xing-Wang; Xing, Yalan; Yi-He Li and Jia-Long Wen. Manganese-mediated coupling reaction of vinylarenes and aliphatic alcohols. Sci. Rep. 2015, 5, 15250.
19. Lan, Xing-Wang; Wang, Nai-Xing*; Bai, Cui-Bing; Zhang, Wei; Xing, Yalan * Wen, Jia-Long; Wang, Yan-Jing and Yi-He Li. Ligand-mediated and Copper-catalyzed C(sp3)-H bond functionalization of aryl ketones with sodium sulfinates under mild conditions. Sci. Rep. 2015, 5, 18391.
20. Lan, Xing-Wang; Wang, Nai-Xing*, Zhang, Wei; Wen, Jia-Long; Bai, Cui-Bing; Xing, Yalan;* and Yi-He Li. Copper/Manganese cocatalyzed oxidative coupling of vinylarenes with ketones. Org. Lett. 2015, 17, 4460.
21. Zhang, J. X.; Wang, Y. J. Zhang, W. Wang, Nai-Xing*, Bai, C. B.; Li, Y. H.; Wen, J. L. Selective Nickel- and Manganese-Catalyzed Decarboxylative Cross Coupling of Some α,β-Unsaturated Carboxylic Acids with Cyclic Ethers Sci. Rep. 2014, 4, 7446.
22. Zhou, Y. Q.; Wang, Nai-Xing*, et al. Stable Acyclic Aliphatic Solid Enols: Synthesis, Characterization, X-Ray Structure Analysis and Calculations. Sci. Rep. 2013, 3, 1058.
23. Xing, Y.; Wang, Nai-Xing*. Organocatalytic and Metal-Mediated Asymmetric [3+2] Cycloaddition Reactions. Coordin. Chem. Rev. 2012, 256, 938.
24. Wang, Nai-Xing*. China’s Chemists Should Avoid the Vanity Fair. Nature 2011, 476, 253.
25. Zhang, Jun-Ping; Wang, Nai-Xing*; et al. Hydrogenation of [60]Fullerene with Lithium in Aliphatic Amines. Carbon 2004, 42, 675.
26. Wang, Nai-Xing*; Jia Zhao, A Novel NADH Model: Design, Synthesis, and its Chiral Reduction and Fluorescent Emission. Adv. Synth. Catal. 2009, 351, 3045.
27. Tang, S. P.; Peng, S-F. Liang, P. Y. Wang, Nai-Xing*; Li, J.-H.* Sequential Intermolecular Aminopalladation/ortho-Arene C-H Activation Reactions of N-Phenylpropiolamides with Phthalimide. Org. Lett. 2008, 10, 1179.
28. Tang, S.; Peng, P. Z.; Wang, Q.; Tang, B. X.; Deng, C. L.; Li, J. H.; Zhong, P.; Wang, Nai-Xing*. Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates involving a C-H Functionalization Process. Org. Lett. 2008, 10, 1875.
29. Zhang, T.; Wang, N. X. Xing, Y. Advances in Decarboxylative Oxidative Coupling Reaction. J. Org. Chem. 2018, 83, 7559.
30. Zhou, Y. Q.; Wang, Nai-Xing*; et al. [4+3] Cycloaddition of Aromatic α,β-Unsaturated Aldehydes and Ketones with Epoxides: One-Step Approach to Synthesize Seven-Membered Oxacycles Catalyzed by Lewis Acid. J. Org. Chem. 2011, 76, 669.
31. Xing-Wang Lan, Nai-Xing Wang,* and Yalan Xing. Recent Advances in Radical Difunctionalization of Simple Alkenes. Eur. J. Org. Chem. 2017, 5821.
32. Huang, Z.; and Wang, Nai-Xing*. Enantioselective Friedel-Crafts Alkylation Reaction of Thiophenes with Ethyl Glyoxylate: An Easy Access to Chiral Secondary Alcohols. Eur. J. Org. Chem. 2011, 5, 843.
33. Wang, Nai-Xing*; Zhang, Jun-Ping. Preparation and Decomposition of C60H36. J. Phys. Chem. A 2006, 110, 6276.
34. Tong Zhang, Nai-Xing Wang, Yue-Hua Wu, Zhan Yan, Yalan Xing, Jia-Long Wen, Xue-Wang Gao. Direct alkylation of thiophenes via bis-coupling with vinyl acetates. Tetrahedron Lett. 2018, 59, 4525.
35. Wang, Nai-Xing*. Photochemical Addition Reactions of [60]Fullerene with 1,2-Ethylenediamine and Piperazine. Tedrahedron 2002, 58, 2377.
36. Wang, Nai-Xing*; et al. Some Thermal Decomposition Reaction of C60H36. Tedrahedron Lett. 2001, 42, 7911.
37. Wang, Naixing; Li, Jisheng; Zhu, Daoben; Chan, Takhang. A C60 Derivatized Dipeptide. Tetrahedron Lett. 1995, 36, 431.
38. Bettinger, H. F.; Rabuck, A. D.; Scuseria, G. E.; Wang, Nai-Xing; et al. Pathways for the Thermally Induces Dehydrogenation of C60H2. Chem. Phys. Lett. 2002, 360, 509.
39. Sun, Y. P*.; et al. Wang, Naixing; et al. Photophysical and Nonlinear Optical Properties of [60]Fullerene Derivatives. J. Phys. Chem. A 1998, 102, 5520.
40. Cui-Bing Bai, Nai-Xing Wang*, Yalan Xing*, Xing-Wang Lan. Progress on Chiral NAD(P)H Model Compounds. Synlett 2017, 28, 402.
41. Yu, An-Guang; Wang, Nai-Xing*; Xing, Ya-Lan; et al., A Convenient Synthesis of 1-[6-Fluoro-(2S)-3H,4H-dihydro-2H-2-chromenyl]- (1R)-1,2-ethanediol and 1-[6-Fluoro-(2R)-3H,4H-dihydro- 2H-2-chromenyl]- (1R)-1,2-ethanediol. Synlett 2005, 9, 1465.
42. Wang, Nai-Xing*; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen. A Novel Synthesis of (S,R,R,R)-α,α’- (Iminobis- (methylene))-Bis-(6-fluoro-3H,4H- dihydro-2H-1- benzopyran-2- methanol). Synthesis 2007, 8, 1154.
43. Tang, S.; Li, J. H.*; Xie, Y. X.; Wang, Nai-Xing*. Halogenation of Indoles with Copper(II) Halides: Selective Synthesis of 2-Halo-, 3-Halo-, and 2,3-Dibromoindoles, Synthesis 2007, 10, 1535.
44. Tang, S.; Xie, Y. X.; Li, J. H.*; Wang, Nai-Xing*. PdX2/CuX2-Catalyzed Annulation of 2-Ethynylbenzeneamines: Selective Synthesis of 2-Substituted 3-Halo-1H-Indoles, Synthesis 2007, 12, 1841.
45. Wang, Nai-Xing*; Zhao, Jia. Progress in Coenzyme NADH Model Compounds and Asymmetric Reduction of Benzoylformate. Synlett 2007, 18, 2785.
46. Huang, Z.; Zhang, J.; Wang, Nai-Xing*.The study of Friedel-Crafts alkylation reaction of thiophenes with glyoxylate imine catalyzed by Fe(III): an easy access to α-aminoesters. Tetrahedron 2011, 67, 1788.
47. Zhou, S. B.; Zhou, Y. Q.; Wang, Nai-Xing*; et al. Exploration on Asymmetric Synthesis of Flavanone Catalyzed by (S)-Pyrrolidinyl Tetrazole, Chirality 2011, 23, 504.
48. Wang, Nai-Xing, Wang, Y. J.; Xing Y. Asymmetric Synthesis of Chiral Flavanone and Chromanone Derivatives. Curr. Org. Chem. 2013, 17, 1555.
49. Zhang, J. X.; Wang, Y. Wang, Nai-Xing*, et al. Nickel-Catalyzed sp3 C–H Bond Activation from Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Amides. Synlett 2014, 11, 1621.
50. Zhang, Wei; Wang, Nai-Xing*, Xing, Y. Advances in transition metal  catalyzed direct C(sp3)-H bond functionalization. Synlett 2015, 26, 2088.
51. Chen, Dong-Dong; Wang, Nai-Xing*, Lan, Xing-Wang; Zhang, Wei; Bai, Cui-Bing; Geng, Hui-Ling; Zhou, Le; Li, Yi-He. Efficient Synthesis of Polysubstituted Tetrahydrothiopyran Sulfoxides by the Reaction of Unsaturated Ketones and Na2S. Curr. Org. Synth. 2016, 13, 651.
52. Bai, Cui-Bing; Wang, Nai-Xing*; Xing, Yalan*; Lan, Xing-Wang. Progress on Chiral NAD(P)H Model Compounds. Synlett 2017, 28, 402.
53. Tong Zhang, Xing-Wang Lan, Yu-Qiang Zhou, Nai-Xing Wang, Yue-Hua Wu, Yalan Xing, Jia-Long Wen. C(sp3)–H bond functionalization of non-cyclic ethers by decarboxylative oxidative coupling with α,β-unsaturated carboxylic acids. Science China Chem. 2018, 61, 180.
54. Wang, Nai-Xing*. The Synthesis Methods of Complex Chiral Compounds by Natural Chiron. Science China Chem. 2010, 40, 295.
55. Zhang, W.; Wang, Y. J.;  Bai, C. B. Wen, J. L. Nai-Xing Wang, Nai-Xing. One-Pot Synthesis of Aliphatic Nitro Compounds by Michael/retro-Claisen Fragmentation Domino Reaction. Chin. J. Chem. 2015, 33, 401-404.
56.  Wang, Naixing; Li, Jisheng. The Reaction of Amino Acid Derivatives with C60. Chin. J. of Chem., 1996, 14(2), 167.
57.  Wang, Naixing; Li, Jisheng. Synthsis of Ball-Chain System Azafulleroids. Chin. J. of Chem., 1996, 14(4), 367-369.

​

1. Wang, Nai-Xing, et al. Synthesis of acebutolol CN 02158786.8 

2. Wang, Nai-Xing, et al. Process for preparation of 5-(butrylamino)- hydroxyaceto-phenone, CN 03119397.8 (ZL 02158786.8

3. Wang, Nai-Xing; Yu, An-Guang, Process for preparation of chiral 2-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-fluoro-2,3-dihydrobenzopyran-4-one, 2003, CN 1629164. (ZL 03119397.8)

4. Wang, Nai-Xing; Yang, Yun-Xu, Preparationof optically pure 6-fluoro-3,4-dihydro—2H-1-benzopyran-2-carboxylic acids and seters by chiral resolution of the racemates with chiral amines, CN 1629154, 2004

5. Wang, Nai-Xing; 2004, CN 200410009493.1

6. Wang, Nai-Xing, 2005, CN 200510011446.5

7. Wang, Nai-Xing; Wang, Wu-Wei, Synthetic method of polynitr- fullerene compound. 2005，CN 200510011967.0

8. Wang, Nai-Xing; 2005， CN 200510124109.7

9. Wang, Nai-Xing, 2004，ZL 2004 1 0009492.7

10. Wang, Nai-Xing; Yu, An-Guang; et al. A Process for Preparation of (S,R,R,R)-α,α’-(iminobis(methylene))-bis-(6-fluoro-3H,4H-dihydro-2H- 1-benzopyran-2-methanol), 2005, CN 200510125663.7

11. Wang, Nai-Xing; 2007, 200710118123.5.

12. Wang, Nai-Xing; Zhang, Jun-Ping. Manufacture of Fullerene derivative C60H36 as hydrogen storage material, 2004, CN 1600684.

    Professor Wang completed the total synthesis of one complicated biologically and pharmacologically active molecule (Nebivolol) with four chiral centers by developing natural-chirality-origin asymmetric synthesis. Some very skillful method and strategies were used and some expensive reagents were avoided. Some theoretic problems were solved also through the calculation of quantum chemistry. ( Synthesis 2007, 8, 1154.; Synlett 2005, 9, 1465.）
    A novel chiral NADH model with C₃ symmetry was synthesized with a view to developing new chemoselective and enantioselective reducing agents by Prof. Nai-Xing Wang. Its special bowl-shaped conformation could encase and fix some substrates and three hydrogens at the C4 position of all dihydropyridine rings in the inner part of the bowl could transfer to the substrate, a novel powerful reducing agent was obtained, an account paper was published in Synlett in 2007, and research paper about it was published in 2009. ( Adv. Synth. Catal. 2009, 351, 3045.)
    Professor Nai-Xing Wang research on the new methodology of organic synthesis, especially on the asymmetric synthesis. A lot of good paper were published on the core journals of organic chemistry, such as Org. lett.; J. Org. Chem.; Adv. Synth. Catal.; Coordin. Chem. Rev. and Nature. So far, more than 180 papers have been published in scientific journals in both foreign and domestic such as Sci. China Chem. And the most recent one is Eur. J. Org. Chem. 2017, 5821, which has 408 citations; Org. Lett. 2008, 10, 1179 (citations: 92)；Org. Lett. 2008, 10, 1875 (citations: 86)；Org. Lett. 2015, 17, 4460 (citations: 73)；Org. Lett. 2016, 18, 5986 (citations: 53); Coordin. Chem. Rev. 2012, 256, 938 (citations: 72). Professor Wang obtained 11 Authorized  patents and published four monographs， and also served as a reviewer for core professional publications of ACS in the United States.

     Professor Wang once published many papers about the synthesis of polynitrogen derivatives of Fullerene and published some papers in this field, such as J. Phys. Chem.; Carbon; Tetrahedron and Chem. Phys. Lett. and so on. Before in 1992, professor Wang once researched on the synthesis of some heterocyclic systems benzofuroxan compounds which could be used as energetic materials, more than ten papers were published on this field, such as in PEP Journal of Wiley-VCH.