Qiuliyang YU, PhD

email: q.yu"at"

Shenzhen Institute of Advanced Technology

Chinese Academy of Sciences

Research Areas

Science is science, but doing science is an art.

We believe having the following abilities gives rise to paradigm-shifting scientific advances:

1) Developing deep insights.

2) Thinking out of the box.

3) Getting things done.

We look for students and researchers with different backgrounds to join our cross-disciplinary team for biomedical research. We offer you a great platform and the flexibility so that you can culture your ideas into real impacts!

We are a team specialized in protein engineering. We design protein machineries and tools to enable drug discoveries and disease diagnostics. Enabling personalized aging management is one of our focuses. We have designed the world-leading bioluminescent protein sensor for NAD+, making fast, portable, and accurate NAD+ detection possible, which further enables the personalized and data-guided administration of NAD+ precursors. NAD+ is a key molecule for regulating various age-induced diseases. While the world population gaining age, NAD+ pathway as a drug target holds an increasing potential for both fundamental research and commercialization. Here, we focus on the following research areas:

1) Protein sensors and medical devices for clinical detection of age-related metabolites.

2) Live cell drug screening platform of age-related metabolites for pharmacological intervention of aging.

3) Live animal imaging platform for age-related metabolites.

4) Monitoring of age-related biomarkers for cancer and immune systems.


1.            Q. Yu et al., A Biosensor for Measuring NAD+ levels at the Point of Care. Nature Metabolism 1, 1219. (Dec 13, 2019).

2.            Q. Yu et al., Semisynthetic Sensor Proteins Enable Metabolic Assays at the Point of Care. Science 361, 6407 (Sep 14, 2018).

3.            J. Hiblot, Q. Yu et al., Luciferases with Tunable Emission Wavelengths. Angewandte Chemie 56, 14556 (Nov 13, 2017).

4.            L. Xue, Q. Yu, R. Griss, A. Schena, K. Johnsson, Bioluminescent Antibodies for Point-of-Care Diagnostics. Angewandte Chemie 56, 7112 (Jun 12, 2017).

5.            Q. Yu, R. Griss, A. Schena, K. Johnsson, Highly Modular Bioluminescent Sensors for Small Molecules and Proteins. Methods in enzymology 589, 365 (2017).

6.            N. Gasilova, Q. Yu (co-first), L. Qiao, H. H. Girault, On-chip spyhole mass spectrometry for droplet-based microfluidics. Angewandte Chemie 53, 4408 (Apr 22, 2014).

7.            J. Zhang et al., An electrochemical and surface plasmon resonance study of adsorption actions of DNA by Escherichia coli. Colloids and surfaces. B, Biointerfaces 117, 68 (May 1, 2014).

8.            J. X. Dong et al., Mitochondrial dysfunction induced by honokiol. The Journal of membrane biology 246, 375 (May, 2013).

9.            X. L. Han et al., Spectroscopic, structural and thermodynamic properties of chlorpyrifos bound to serum albumin: A comparative study between BSA and HSA. Journal of photochemistry and photobiology. B, Biology 109, 1 (Apr 2, 2012).

10.         X. Han et al., Toxicity of CdTe quantum dots on yeast Saccharomyces cerevisiae. Small 8, 2680 (Sep 10, 2012).

11.         R. Li et al., Microcalorimetric, spectroscopic and microscopic investigation on the toxic effects of CdTe quantum dots on Halobacterium halobium R1. Nanotechnology 21, 475102 (Nov 26, 2010).



杨合  硕士研究生  085600-材料与化工  

阮华明  硕士研究生  086000-生物与医药