生物分子自组装与生物医学工程：生物材料与剂型、抗肿瘤药物及治疗新方法

   

2023-09~现在, 中国科学院过程工程研究所, 博士生导师，项目研究员
2019-07~2023-09,中国科学院过程工程研究所, 硕士生导师，副研究员
2017-07~2019-07,中国科学院过程工程研究所, 助理研究员

分子酶工程

   

   

（1） Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications, Chem. Soc. Rev, 2023, 通讯作者
（2） Steering phase-separated droplets to control fibrillar network evolution of supramolecular peptide hydrogels, MATTER, 2023, 第 2 作者
（3） Peroxidase-triggered formation of fluorescent peptide-based nanoarchitectonics, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2022, 通讯作者
（4） Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy, ADVANCED MATERIALS, 2021, 通讯作者
（5） Self-assembled natural biomacromolecular fluorescent hydrogels with tunable red edge effects, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2021, 通讯作者
（6） Cyclic dipeptides: Biological activities and self-assembled materials, PEPTIDE SCIENCE, 2021, 通讯作者
（7） Silver-incorporating peptide and protein supramolecular nanomaterials for biomedical applications, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 第 3 作者
（8） Tumor Therapy Based on Self-Assembling Peptides Nanotechnology, View, 2020, 
（9） Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy, JOURNAL OF CONTROLLED RELEASE, 2020, 第 3 作者
（10） Injectable Self-assembled Bola-dipeptide Hydrogels for Sustained Photodynamic Prodrug Delivery and Enhanced Tumors Therapy, J. Control. Release, 2020, 
（11） Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly, CHEMICAL SCIENCE, 2020, 通讯作者
（12） Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 3 作者
（13） 肽基超分子胶体, Peptide-based Supramolecular Colloids, 物理化学学报, 2020, 第 1 作者
（14） Peptide-based Supramolecular Colloids, ACTA PHYSICO-CHIMICA SINICA, 2020, 第 1 作者
（15） Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly, SMALL, 2020, 第 4 作者
（16） Peptide-coordination self-assembly for the precise design of theranostic nanodrugs, COORDINATION CHEMISTRY REVIEWS, 2019, 第 2 作者
（17） A versatile cyclic dipeptide hydrogelator: self-assembly and rheology in various physiological conditions, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 第 2 作者
（18） Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly, ACS NANO, 2019, 
（19） Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 4 作者
（20） Self-assembled injectable biomolecular hydrogels towards phototherapy, NANOSCALE, 2019, 第 1 作者
（21） Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics, CHEMISTRY-A EUROPEAN JOURNAL, 2019, 第 4 作者
（22） The dominant role of oxygen in modulating the chemical evolution pathways of tyrosine in peptides: dityrosine or melanin, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 5 作者
（23） Supramolecular photothermal nanomaterials as an emerging paradigm toward precision cancer therapy, ADVANCED FUNCTIONAL MATERIALS, 2019, 第 4 作者
（24） Peptide-Based Supramolecular Nanodrugs as a New Generation of Therapeutic Toolboxes against Cancer, ADVANCED THERAPEUTICS, 2019, 第 3 作者
（25） Self-assembling endogenous biliverdin as a versatile near-infrared photothermal nanoagent for cancer theranostics, ADVANCED MATERIALS, 2019, 第 1 作者
（26） Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2019, 第 5 作者
（27） Hierarchically oriented organization in supramolecular peptide crystals, NATURE REVIEWS CHEMISTRY, 2019, 第 3 作者
（28） Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 通讯作者
（29） Recent advances of self-assembling peptide-based hydrogels for biomedical applications, SOFT MATTER, 2019, 第 2 作者
（30） Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy, Small, 2019, 第 4 作者
（31） Covalently assembled dipeptide nanoparticles with adjustable fluorescence emission for multicolor bioimaging, CHEMBIOCHEM, 2019, 第 3 作者
（32） Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics, THERANOSTICS, 2019, 第 3 作者
（33） High-tolerance crystalline hydrogels formed from self-assembling cyclic dipeptide, BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2019, 第 2 作者
（34） Fabrication of hierarchical MXene-based AuNPs-containing core-shell nanocomposites for high efficient catalysts, Fabrication of hierarchical MXene-based AuNPs-containing core-shell nanocomposites for high efficient catalysts, GREEN ENERGY & ENVIRONMENT, 2018, 第 3 作者
（35） Preparation and enhanced structural integrity of electrospun poly(epsilon-caprolactone)-based fibers by freezing amorphous chains through thiol-ene click reaction, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 4 作者
（36） Covalent assembled dipeptide nanoparticles with adjustable fluorescence emission for multi-color bio-imaging, ChemBioChem, 2018, 
（37） Fabrication of tunable hierarchical MXene@AuNPs nanocomposites constructed by self-reduction reactions with enhanced catalytic performances, SCIENCE CHINA-MATERIALS, 2018, 第 3 作者
（38） Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 1 作者
（39） Self-Assembled Composite Langmuir Films via Fluorine-Containing Bola-Type Derivative with Metal Ions, COATINGS, 2018, 第 6 作者
（40） Preparation of MoS2-based polydopamine-modified core-shell nanocomposites with elevated adsorption performances, RSC ADVANCES, 2018, 第 3 作者
（41） Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy, CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2018, 第 2 作者
（42） An injectable dipeptide-fullerene supramolecular hydrogel for photodynamic antibacterial therapy, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 第 4 作者
（43） Supramolecular photothermal nanomaterials as an emerging paradigm towards precision cancer therapy, Adv. Funct. Mater., 2018, 
（44） Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from b-Sheet to a-Helix, Angew. Chem. Int. Ed., 2018, 
（45） Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 4 作者
（46） Antitumor Photodynamic Therapy Based on Dipeptide Fibrous Hydrogels with Incorporation of Photosensitive Drugs, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2018, 第 2 作者
（47） Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy, CHEMISTRY-AN ASIAN JOURNAL, 2018, 第 3 作者
（48） Amino acid coordination driven self-assembly for enhancing both the biological stability and tumor accumulation of curcumin, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 5 作者
（49） Self-assembled MXene-based nanocomposites via layer-by-layer strategy for elevated adsorption capacities, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 4 作者
（50） Amino Acid Coordination-Driven Self-Assembly for Enhancing both Biological Stability and Tumor Accumulation of Curcumin, Angew. Chem. Int. Ed., 2018, 
（51） Facile preparation and electrochemical characterization of self-assembled core-shell diamond-polypyrrole nanocomposites, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 3 作者
（52） Crystalline Dipeptide Nanobelts Based on Solid-Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 2 作者
（53） Facile synthesis of self-assembled carbon nanotubes/dye composite films for sensitive electrochemical determination of Cd(II) ions, NANOTECHNOLOGY, 2018, 第 4 作者
（54） Kinetically Controlled Self-Assembly of Phthalocyanine-Peptide Conjugate Nanofibrils Enabling Super-Large Redshifted Absorption, CCS Chem., 2018, 
（55） Self-Assembled AgNP-Containing Nanocomposites Constructed by Electrospinning as Efficient Dye Photocatalyst Materials for Wastewater Treatment, NANOMATERIALS, 2018, 第 6 作者
（56） Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 5 作者
（57） Selective Cu(II) ion removal from wastewater via surface charged self-assembled polystyrene-Schiff base nanocomposites, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2018, 第 4 作者
（58） Variable self-assembly and in situ host-guest reaction of beta-cyclodextrin-modified graphene oxide composite Langmuir films with azobenzene compounds, RSC ADVANCES, 2017, 第 4 作者
（59） 二肽水凝胶流变学调控及免疫激活抗肿瘤研究, 中国化学会第十六届胶体与界面化学会议论文摘要集——第五分会：生命科学与医学中的胶体化学, 2017, 第 1 作者
（60） Preparation of diamond-based AuNP-modified nanocomposites with elevated catalytic performances, RSC ADVANCES, 2017, 第 3 作者
（61） Self-Assembled Injectable Peptide Hydrogels Capable of Triggering Antitumor Immune Response, BIOMACROMOLECULES, 2017, 第 1 作者
（62） Bioinspired Polydopamine Sheathed Nanofibers Containing Carboxylate Graphene Oxide Nanosheet for High-Efficient Dyes Scavenger, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2017, 第 1 作者
（63） Fabrication of Hierarchical Layerby-Layer Assembled Diamondbased Core-Shell Nanocomposites as Highly Efficient Dye Absorbents for Wastewater Treatment, SCIENTIFIC REPORTS, 2017, 第 4 作者
（64） Construction and self-assembly of beta-cyclodextrin derivative composite Langmuir films: Host-guest reaction and nanostructures, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2017, 第 3 作者
（65） Hierarchical AuNPs-Loaded Fe3O4/Polymers Nanocomposites Constructed by Electrospinning with Enhanced and Magnetically Recyclable Catalytic Capacities, NANOMATERIALS, 2017, 第 3 作者
（66） Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2017, 第 3 作者
（67） Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy, SCIENTIFIC REPORTS, 2017, 第 4 作者
（68） Graphene Oxide-Polymer Composite Langmuir Films Constructed by Interfacial Thiol-Ene Photopolymerization, NANOSCALE RESEARCH LETTERS, 2017, 第 4 作者
（69） Biomimetic Oxygen-Evolving Photobacteria Based on Amino Acid and Porphyrin Hierarchical Self-Organization, ACS NANO, 2017, 第 3 作者
（70） Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long-Term Stable Hydrophobic Nanodrugs towards Effective Anticancer Therapy, ACS Nano, 2016, 第 1 作者
（71） Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy, POLYMERS, 2016, 第 1 作者
（72） 可注射胶原蛋白-纳米金自组装水凝胶用于光热/光动力抗肿瘤治疗, 中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学, 2016, 第 1 作者
（73） Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles, SCIENTIFIC REPORTS, 2016, 第 1 作者
（74） Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 2 作者
（75） Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy, ACS NANO, 2016, 第 2 作者
（76） Mimicking Primitive Photobacteria: Sustainable Hydrogen Evolution Based on Peptide-Porphyrin Co-Assemblies with a Self-Mineralized Reaction Center, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 2 作者
（77） Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 2 作者
（78） Peptide self-assembly: thermodynamics and kinetics, CHEMICAL SOCIETY REVIEWS, 2016, 第 3 作者
（79） Preparation and dye removal capacities of porous silver nanoparticle-containing composite hydrogels via poly(acrylic acid) and silver ions, RSC ADVANCES, 2016, 第 4 作者
（80） An Injectable Self-Assembling Collagen-Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic Therapy, ADVANCED MATERIALS, 2016, 第 1 作者
（81） Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 2 作者
（82） 可注射的光活性胶原蛋白水凝胶及抗肿瘤应用研究, 中国化学会第十五届胶体与界面化学会议论文集（第三分会）, 2015, 第 1 作者
（83） Photothermally-Induced Molecular Self-Assembly of Macroscopic Peptide-Inorganic Hybrid Films, SCIENCE OF ADVANCED MATERIALS, 2015, 第 1 作者
（84） Peptide-Induced Hierarchical Long-Range Order and Photocatalytic Activity of Porphyrin Assemblies, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 第 2 作者
（85） Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth, ACS APPLIED MATERIALS & INTERFACES, 2015, 第 1 作者
（86） Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools, CHEMISTRY-A EUROPEAN JOURNAL, 2014, 第 4 作者
（87） 寡肽调控光敏剂自组装及物化性质研究3, 中国化学会第三届全国生物物理化学会议暨国际华人生物物理化学发展论坛论文摘要集, 2014, 第 4 作者

   

（ 1 ） 基于卟啉的近红外吸收光热颗粒：小分子肽调节的自组装、作用机制和肿瘤治疗应用研究, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 抗原肽自组装：分子设计、结构调控与肿瘤免疫治疗应用研究, 负责人, 国家任务, 2021-01--2024-12
（ 3 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2021-01--2024-12
（ 4 ） 先进佐剂技术与免疫增效, 负责人, 中国科学院计划, 2023-07--2028-06
（ 5 ） 色素肽功能化细菌及肿瘤光热免疫治疗应用, 负责人, 国家任务, 2024-01--2027-12
（ 6 ） 北京市科技新星计划, 负责人, 地方任务, 2023-10--2026-10