The lab focuses on neural mechanisms of addiction in animal models, such as rats, chicken and tree shrews,and extented to human studies recently. We also branched out to look at depression from a learning-and-memory/affective angle.

Techniques
We routinely employ behavioral paradigms, pharmacological intervention, biochemical analyses, and molecular and cellular assays.

Current Projects

Neural mechanisms of addiction: memory reconsolidation and epigenetics, affective memory, reward system, cognitive control and affective decision-making.
Neural mechanisms of depression: behavioral models of depression in tree shrews (lower primate) and rats, and pharmacological studies of antidepressants.
Effects of prenatal exposure of abusive drugs and mechanisms.

2007/01--2007/12   Visiting Researcher, EPFL,  Swiss;

2003/01--2003/04   Visiting Researcher,  Michigan Univerisity,Mayo Medical School, USA;

1998/07--1998/10   Visiting Researcher, Dept. of Biopsychology, UNED, Spain;

1995/10--1996/10   Visiting Researcher, Open University, UK;

1987/09--1990/07   M.S. Institute of Psychology, Chinese Academy of Science, Beijing.

1998 – present   Professor, Institute of Psychology, CAS
1996 – 1998      Associate Professor, Institute of Psychology, CAS
1992 – 1996      Assistant Professor, Institute of Psychology, CAS

   

(1) Peng Liu (#)，Jianjun Zhang  (#)，Ming Li，Nan Sui(*) ，Distinctive Roles of 5-aza-2′-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.，Frontiers in Behavioral Neuroscience，2016，10.

(2) Ying Duan(#) ，Fang Shen  (#)，Tingting Gu，Nan Sui(*)，Addiction: from context-induced hedonia to appetite, based on transition of micro-behaviors in morphine abstinent tree shrews.，Frontiers in Psychology，2016，7：816.

(3) Jun Gao，Min Feng，Natashia Swalve，Collin Davis， Nan Sui(*)，Ming Li(*)，Effects of repeated quetiapine treatment on conditioned avoidance responding in rats，European Journal of Pharmacology，2015，769：154-161.

(4) Min Feng ，Jun Gao，Nan Sui(*)，Ming Li (*)，Effects of central activation of serotonin 5-HT2A/2C or dopamine D-2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test，Psychopharmacology，2015，232（7）：1219-1230.

(5) Jianjun Zhang(#) ，Jin Han，Nan Sui(*) ，Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats.，Neuropharmacology，2014，86：282-293.

(6) Weihai Chen (#)(*)，Qi Zhang，Wenxin Su，Haorong Zhang，Yu Yang，Jing Qiao， Nan Sui(*)，Ming Li(*)，Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats.，Pharmacology Biochemistry and Behavior，2014，117：25-33.

(7) Wansen Yan，Yonghui Yan， Nan Sui(*)，The relationship between recent stressful life events, personality traits, perceived family functioning and internet addiction among college students.，Stress and Health，2014，30（1）：3-11.

(8) Wansen Yan，Yonghui Li，Lin Xiao，Ning Zhu，Antoine Bechara， Nan Sui(*)，Working memory and affective decision-making in addiction: a neurocognitive comparison between heroin addicts, pathological gamblers and healthy controls.，Drug and Alcohol Dependence，2014，134：194-200.

(9) Yan Wu，Yonghui Li，Xiaoyan Yang， Nan Sui(*)，Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.，Addiction Biology，2014，19（1）：5-15.

(10) Fang Shen，Ying Duan，Shubo Jin， Nan Sui(*)，Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction.，Frontiers in Behavioral Neuroscience，2014，8：333-333.

(11) Xiao Jiang，Jianjun Zhang，Mengya Wang， Nan Sui(*)，Differential Muscarinic Modulation of Synaptic Transmission in Dorsal and Ventral Regions of the Rat Nucleus Accumbens Core，Physiological Research，2014，63（1）：135-142.

(12) Keke Qi，Chuguang Wei，Yonghui Li(*)， Nan Sui(*)，Orexin receptors within the nucleus accumbens shell mediate the stress but not drug

priming-induced reinstatement of morphine conditioned place preference，Frontiers in Behavioral Neuroscience，2013，7.

(13) Chunlu Li，Ning Zhu，Xiaolu Meng，Yonghui Li， Nan Sui(*)，Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats，Journal of Psychopharmacology，2013，27（9）：837-844.

(14) Jun Gao，Yonghui Li，Ning Zhu，Stephen Brimijoin， Nan Sui(*)，Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateralcaudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats，Journal of Psychopharmacology，2013，27（2）：181-191.

(15) Min Feng， Nan Sui(*)，Ming Li(*)，Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further

test of the motivational salience hypothesis，Pharmacology Biochemistry and Behavior，2013，103（3）：467-473.

(16) Chunlu Li，Ning Zhu，Yonghui Li，Xiaolu Meng，Jun Gao， Nan Sui(*)，The Role of Interoception and Insular Cortex in Addiction，Progress in Biochemistry and Biophysics，2013，40（1）：15-21.

(17) Min Feng， Nan Sui(*)，Ming Li(*)，Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel

across-model transfer paradigm.，Behavioural Brain Research，2013，238：178-187.

(18) Jiuqing Cheng，Yanhong Lu，Xiaodong Han，Claudia Gonzalez-Vallejo， Nan Sui(*)，Temporal Discounting in Heroin-Dependent Patients: No Sign Effect, Weaker Magnitude Effect, and the Relationship With Inhibitory Control，Experimental and Clinical Psychopharmacology，2012，20（5）：400-409.

(19) Min Feng， Nan Sui(*)，Ming Li(*)，Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further

test of the motivational salience hypothesis，Pharmacology Biochemistry and Behavior，2012，103（3）：467-473.

(21) Yan Wu，Yonghui Li，Xiaoyan Yang， Nan Sui(*)，Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats，Addic Biol，2012，20（5）：400-409.

(22) Yan Wu，Yonghui Li，Jun Gao， Nan Sui(*)，Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine-related positive and aversive memory in rats，European Journal of Pharmacology，2012，674（2-3）：321-326.

(23) Xu, W.，Li, Y. H.，Tan, B. P.，Luo, X. J.，Xiao, L.，Zheng, X. G.，Yang, X. Y.， Sui, N.(*)，Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats，Physiological Research，2012，61（4）：437-442.

(24) Xiaqin Sun，Xiaolu Meng，Jie Zhang，Yonghui Li，Liping Wang，Xiaoyan Qin(*)， Nan Sui(*)，Yan Zhang(*)，GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment，Journal of Alzheimer's Disease，2012，31（3）：635-649。

(25) Jun Gao，Ning Zhu，Min Feng，Xiaolu Meng， Nan Sui(*)，Intranucleus accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats，PsyCh Journal，2012，1：2-14.

(26) Jiang, Juan，He, Xingu，Wang, Meng-Ya(*)， Sui, Nan(*)，Early prenatal morphine exposure impairs performance of learning tasks and attenuates in vitro heterosynaptic long-term potentiation of intermediate medial mesopallium in day-old chicks，Behavioural Brain Research，2011，219（2）：363-366.

(27) Xingu He，Yunfei Bao，Yonghui Li， Nan Sui(*)，The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks，Neuroscience Letters，2010，482（1）：12-16.

(28) Jin Han，Yonghui Li，Dongmei Wang，Chuguang Wei，Xiaoyan Yang， Nan Sui(*)，Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice，European Journal of

Pharmacology，2010，642（1-3）：93-98.

(29) Lixia Zhao，Yushan Zhu，Dongmei Wang，Ming Chen，Ping Gao，Weiming Xiao，Guanhua Rao，Xiaohui Wang，Haijing Jin，Lin Xu， Nan Sui(*)，Quan Chen(*), Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus，Autophagy，2010，6（3）：386-394.

(30) Xingu He，Lin Xiao， Nan Sui(*)，Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks，European Journal of Pharmacology，2010，627（1-3）：136-141.

(31) Bai, Y. J.，Li, Y. H.，Zheng, X. G.，Han, J.，Yang, X. Y.， Sui, N.(*)，Orexin A attenuates unconditioned sexual motivation in male rats，Pharmacology Biochemistry and Behavior，2009，91（4）：581-589.

(32) Li, YH，Zheng, XG，Bai, YJ，Yang, XY， Sui, N(*)，Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats，Journal of Psychopharmacology，2006，20（1）：40-46.

(33) Ya Yang(#)，Xigeng Zheng(#)，Yongfu Wang，Jun Dong，Zhifang Dong，Jingxia Cai， Nan Sui(*)，Lin Xu(*)，Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: Possible mechanisms for corticosterone on opiate addiction.，Journal of Neuroscience，2004，24（10）：2412-242

The lab focuses on neural mechanisms of psychological disorders, especially those related to learning and memory, and affects and emotion. We believe that pathological learning and memory (neural plasticity) and/or abnormal emotion circuits underly most of psychological disorders. For nearly two decades, we have studied opiate addiction in animal models and extented to human studies recently. In the past few years, we also branched out to look at depression from a learning-and-memory/affective angle.