基本信息
王纪霞 女 中国科学院大连化学物理研究所
电子邮件: jxwang@dicp.ac.cn
通信地址: 辽宁省大连市沙河口区中山路457号
邮政编码: 116023
电子邮件: jxwang@dicp.ac.cn
通信地址: 辽宁省大连市沙河口区中山路457号
邮政编码: 116023
研究领域
中药药效物质研究
招生信息
招生专业
070302-分析化学
招生方向
中药药效活性评价体系的构建方法研究中药先导活性化合物的研究临床有效方剂的机理解析
教育背景
2010-09--2015-09 中国科学院大连化学物理研究所 学生/博士学位2006-09--2010-07 山东师范大学 学生/学士学位
学历
博士研究生
学位
博士学位
工作经历
工作简历
2019-06~现在, 中国科学院大连化学物理研究所, 副研究员2015-11~2019-06,中国科学院大连化学物理研究所, 助理研究员
社会兼职
2022-06-01-2027-07-07,大连药学会天然药物委员,
专利与奖励
奖励信息
(1) 辽宁省“兴辽英才计划”高水平创新创业团队, 省级, 2019
专利成果
[1] 梁鑫淼, 徐芳芳, 王纪霞, 刘艳芳, 曲腊腊, 侯滔. 苍术酮或苍术素作为FFA1激动剂的应用及药物组合物. CN: CN114129555A, 2022-03-04.[2] 梁鑫淼, 王纪霞, 刘艳芳, 魏来, 赵耀鹏, 张岩, 吴乐昊, 相凯婧. 香豆素类衍生物在制备治疗炎症性肠炎药物中应用及药物. CN: CN114129562A, 2022-03-04.[3] 梁鑫淼, 曲腊腊, 王纪霞, 刘艳芳, 金红利. 一种木脂素类化合物及制备与应用和产品. CN: CN113880791A, 2022-01-04.[4] 梁鑫淼, 魏红丽, 刘艳芳, 王纪霞, 侯滔. 双苄基异喹啉生物碱衍生物及制备和应用与药物组合物. CN: CN113730408A, 2021-12-03.[5] 梁鑫淼, 曲腊腊, 侯滔, 刘艳芳, 王纪霞. 无标记精氨酸加压素受体细胞模型构建和配体筛选方法. CN: CN112858673A, 2021-05-28.[6] 梁鑫淼, 徐芳芳, 王纪霞, 刘艳芳, 侯滔, 王盼. 一种紫草液相分离时色谱峰的质量的定量分析方法. CN: CN112461939A, 2021-03-09.[7] 梁鑫淼, 徐芳芳, 张秀莉, 刘艳芳, 王纪霞. 磺酰胺衍生物、其药物组合物和应用. CN: CN112390734A, 2021-02-23.[8] 梁鑫淼, 曲腊腊, 王纪霞, 刘艳芳. 无标记血管紧张素Ⅱ受体细胞模型构建和筛选方法及应用. CN: CN112345745A, 2021-02-09.[9] 梁鑫淼, 王纪霞, 张秀莉, 金郁, 李奎永, 曲腊腊. 一类黄酮苷化合物及其制备方法和应用. CN: [[[CN111690025A]]], [[["2020-09-22"]]].[10] 梁鑫淼, 相凯婧, 周维佳, 王纪霞, 刘艳芳. 一种莪术中强极性成分的分离制备及分析方法和应用. CN: CN111610284B, 2021-07-06.[11] 梁鑫淼, 赵耀鹏, 刘艳芳, 王纪霞, 王长健, 王志伟, 杜娜娜, 张秀莉, 郭志谋, 王超然. 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物. CN: CN110372571A, 2019-10-25.[12] 梁鑫淼, 徐芳芳, 张秀莉, 王纪霞, 曲腊腊, 张鹏宇. FFA4配体的无标记筛选模型. CN: CN111321194A, 2020-06-23.[13] 梁鑫淼, 王荣, 刘艳芳, 张秀莉, 王纪霞. 一种动态质量重置法检测化合物临界聚合浓度的方法. CN: CN111239053A, 2020-06-05.[14] 梁鑫淼, 魏红丽, 金红利, 刘艳芳, 侯滔, 王纪霞, 钮蕊. 一种新双黄酮类化合物及其制备方法和用途. CN: CN111233808A, 2020-06-05.[15] 梁鑫淼, 张鹏宇, 张秀莉, 王纪霞, 侯滔, 周晗. α1A-肾上腺素受体拮抗剂及应用或药物. CN: CN111233805A, 2020-06-05.[16] 梁鑫淼, 魏红丽, 金红利, 刘艳芳, 侯滔, 王纪霞, 钮蕊. 一种有机酸化合物及其制备方法和用途. CN: CN111233662B, 2021-09-28.[17] 梁鑫淼, 曲腊腊, 张秀莉, 王纪霞. 一种无标记内皮素受体细胞模型构建和筛选的方法及应用. CN: CN111239130A, 2020-06-05.[18] 梁鑫淼, 王纪霞, 张秀莉, 张鹏宇, 徐芳芳, 侯滔, 周晗, 魏来, 曲腊腊. 鼠源GPR35高通量筛选模型的构建方法及应用. CN: CN109929805A, 2019-06-25.[19] 梁鑫淼, 张鹏宇, 张秀莉, 王纪霞, 刘艳芳, 王超然, 周维佳. β 2 -肾上腺素受体拮抗剂及应用. CN: CN109893651A, 2019-06-18.[20] 梁鑫淼, 周维佳, 刘艳芳, 金红利, 王纪霞. 一种莪术中β 2 -肾上腺素受体激动剂及其应用. CN: CN109806254A, 2019-05-28.[21] 梁鑫淼, 王纪霞, 张秀莉, 刘艳芳, 朴海龙, 齐欢, 司玮. 柴胡活性成分在制备抗三阴性乳腺癌药物中的应用. CN: CN109549945A, 2019-04-02.[22] 梁鑫淼, 魏来, 张秀莉, 王纪霞, 王平, 侯滔, 曲腊腊, 史丽颖. 3-取代香豆素类衍生物及应用和GPR35受体的激动剂. CN: CN108069929A, 2018-05-25.[23] 梁鑫淼, 侯滔, 张秀莉, 史丽颖, 何牮, 王纪霞, 魏来, 曲腊腊. 一种无标记神经降压素受体(NTSR)配体筛选模型. CN: CN106645735A, 2017-05-10.[24] 梁鑫淼, 史丽颖, 张秀莉, 侯滔, 王纪霞, 何牮, 魏来. 一种组胺H1受体拮抗剂的筛选方法. CN: CN106544392A, 2017-03-29.[25] 梁鑫淼, 史丽颖, 张秀莉, 侯滔, 王纪霞, 何牮, 魏来. 一种组胺H1受体拮抗剂及其筛选方法和应用. CN: CN106539786A, 2017-03-29.[26] 梁鑫淼, 黄润祺, 张秀莉, 王纪霞, 钟正升. 带氨基酸链的蟾蜍二烯内酯类化合物在制备抗癌药物中的应用. CN: CN106265693A, 2017-01-04.[27] 梁鑫淼, 王纪霞, 张秀莉, 刘艳芳, 张云, 黄润祺. 蟾蜍二烯内酯类化合物在制备抗胃癌药物中的应用. CN: CN106138067A, 2016-11-23.[28] 梁鑫淼, 侯滔, 张秀莉, 史丽颖, 王纪霞, 魏来, 何牮. GPR35受体激动剂及其应用. CN: CN106138019A, 2016-11-23.[29] 梁鑫淼, 侯滔, 张秀莉, 史丽颖, 王纪霞, 魏来. 一种GPR35激动剂及其应用. CN: CN105769846A, 2016-07-20.[30] 梁鑫淼, 王纪霞, 张秀莉, 魏来, 史丽颖, 侯滔. 丹参中GPR35受体激动剂和Ca 2+ -ATPase的抑制剂及应用. CN: CN105521016A, 2016-04-27.[31] 梁鑫淼, 王纪霞, 张秀莉, 魏来, 史丽颖, 侯滔. 丹参中GPR35受体激动剂和Ca 2+ -ATPase的抑制剂及应用. 中国: CN105521016A, 2016-04-27.[32] 梁鑫淼, 相凯婧, 魏来, 赵耀鹏, 王纪霞, 侯滔. 可作为GPR35受体荧光探针的二羧酸衍生物的制备与用途. CN: CN115611932A, 2023-01-17.[33] 梁鑫淼, 侯滔, 王纪霞, 徐芳芳, 周晗, 金红利, 刘艳芳. 20(S)-人参皂苷Rg3的应用及药物或GPR35受体拮抗剂. CN: CN115337317A, 2022-11-15.[34] 梁鑫淼, 徐芳芳, 王纪霞, 刘艳芳, 侯滔. GPR120受体激动剂及熊去氧胆酸的应用. CN: CN115137732A, 2022-10-04.[35] 梁鑫淼, 魏红丽, 刘艳芳, 王纪霞, 侯滔. 一种异喹啉生物碱衍生物及其制备和用途. CN: CN114907425A, 2022-08-16.[36] 梁鑫淼, 侯滔, 彭惺蓉, 邱明华, 张秀莉, 周晗, 王纪霞, 徐芳芳. 化合物作为或在制备阿片受体拮抗剂中的应用和药物组合物. CN: CN114588150A, 2022-06-07.[37] 梁鑫淼, 侯滔, 彭惺蓉, 邱明华, 张秀莉, 周晗, 王纪霞, 徐芳芳. 药物组合物及化合物作为或在制备阿片受体拮抗剂中的应用. CN: CN114588143A, 2022-06-07.[38] 梁鑫淼, 魏红丽, 刘艳芳, 王纪霞, 侯滔. 一种二聚异喹啉生物碱化合物及其制备和用途. CN: CN114539217A, 2022-05-27.[39] 梁鑫淼, 魏红丽, 刘艳芳, 王纪霞, 侯滔. 一种原小檗碱-尖防己型生物碱二聚体及其应用和制备. CN: CN114539242A, 2022-05-27.[40] 梁鑫淼, 周晗, 侯滔, 王超然, 王纪霞. 化合物作为或制备多巴胺受体拮抗剂中的应用及拮抗剂. CN: CN114539145A, 2022-05-27.[41] Delta阿片受体偏向激动化合物的合成与应用和镇痛药物. 2022-12-12.[42] 一种受体拮抗剂长效性分析方法. 2019-10-14.[43] 穗花杉双黄酮在制备ACLY相关疾病药物或抑制ACLY活性药物中的用途及药物组合物. 2023-06-13.
出版信息
发表论文
[1] Zhao, Yaopeng, Wang, Jixia, Hou, Tao, Yu, Yancheng, Zhou, Han, Han, Yang, Cheng, Junxiang, Liu, Yanfang, Wang, Chaoran, Chen, Long, Liang, Xinmiao. Design and synthesis of 2-(2,2-diarylethyl)-cyclamine derivatives as M3 receptor antagonists and functional evaluation on COPD. BIOORGANIC CHEMISTRY[J]. 2023, 第 2 作者131: http://dx.doi.org/10.1016/j.bioorg.2022.106308.[2] Xu, Yang, Wang, Rong, Hou, Tao, Li, Hao, Han, Yang, Li, Yan, Xu, Linli, Lu, Shubin, Liu, Lei, Cheng, JunXiang, Wang, JiXia, Xu, Qing, Liu, Yanfang, Liang, Xinmiao. Uncariphyllin A-J, indole alkaloids from Uncaria rhynchophylla as antagonists of dopamine D2 and Mu opioid receptors. BIOORGANIC CHEMISTRY[J]. 2023, 第 11 作者130: http://dx.doi.org/10.1016/j.bioorg.2022.106257.[3] Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang. Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia. FITOTERAPIA. 2023, 第 10 作者 通讯作者 171: http://dx.doi.org/10.1016/j.fitote.2023.105712.[4] Zhao, Xinwei, Yu, Dongping, Zhou, Weijia, Yu, Long, Zhou, Han, Liu, Yanfang, Guo, Zhimou, Shen, Aijing, Han, Ziwei, Wang, Chaoran, Wang, Jixia, Liang, Xinmiao. Chemical profiling of Ziziphi spinosae semen using on-line comprehensive two-dimensional liquid chromatography-mass spectrometry based on a novel phthalic anhydride bonded stationary phase. JOURNAL OF SEPARATION SCIENCE[J]. 2023, 第 11 作者 通讯作者 46(10): http://dx.doi.org/10.1002/jssc.202200704.[5] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 第 7 作者159: http://dx.doi.org/10.1016/j.fitote.2022.105175.[6] Han, Yang, Hou, Tao, Zhang, ZiHui, Zhu, YunHui, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Corybungines A-K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity. PHYTOCHEMISTRY[J]. 2022, 第 7 作者199: http://dx.doi.org/10.1016/j.phytochem.2022.113209.[7] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 第 7 作者159: http://dx.doi.org/10.1016/j.fitote.2022.105175.[8] International Journal of Molecular Sciences. 2022, 通讯作者 [9] Wei, Lai, Hou, Tao, Li, Jiaqi, Zhang, Xiuli, Zhou, Han, Wang, Zhenyu, Cheng, Junxiang, Xiang, Kaijing, Wang, Jixia, Zhao, Yaopeng, Liang, Xinmiao. Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 第 9 作者64(5): 2634-2647, http://dx.doi.org/10.1021/acs.jmedchem.0c01624.[10] Wei, Hongli, Han, Yang, Wang, Jixia, Hou, Tao, Yao, Yumin, Jin, Jingmei, Zhao, Tianyuan, Zhang, Xiuli, Liu, Yanfang, Liang, Xinmiao. Analgesic bisbenzylisoquinoline alkaloids from the rhizoma of Menispermum dauricum DC. BIOORGANIC CHEMISTRY[J]. 2021, 第 3 作者107: http://dx.doi.org/10.1016/j.bioorg.2020.104517.[11] Hou, Tao, Xu, Fangfang, Peng, Xingrong, Zhou, Han, Zhang, Xiuli, Qiu, Minghua, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2021, 第 7 作者 通讯作者 270: http://dx.doi.org/10.1016/j.jep.2021.113872.[12] Xu, Fangfang, Wang, Pan, Zhang, Xiuli, Hou, Tao, Qu, Lala, Wang, Chaoran, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst. PHARMACOLOGICAL RESEARCH[J]. 2021, 第 7 作者 通讯作者 163: http://dx.doi.org/10.1016/j.phrs.2020.105173.[13] 徐芳芳, 张秀莉, 侯滔, 曲腊腊, 王纪霞, 刘艳芳, 梁鑫淼. 天然产物中FFA1受体新激动剂的发现与研究. 上海中医药大学学报[J]. 2021, 第 5 作者35(1): 12-19, http://lib.cqvip.com/Qikan/Article/Detail?id=7104082893.[14] Wang, JiXia, Zhao, YaoPeng, Du, NaNa, Han, Yang, Li, Hao, Wang, Rong, Xu, Yang, Liu, YanFang, Liang, XinMiao. Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica. ORGANIC LETTERS[J]. 2020, 第 1 作者22(21): 8240-8244, http://dx.doi.org/10.1021/acs.orglett.0c02838.[15] Qu, Lala, Zhang, Xiuli, Wang, Jixia, Zhou, Han, Hou, Tao, Wei, Lai, Xu, Fangfang, Liang, Xinmiao. Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY[J]. 2020, 第 3 作者393(6): 937-950, http://dx.doi.org/10.1007/s00210-019-01756-6.[16] Wang, Rong, Liu, Yanfang, Zhou, Han, Chen, Yue, Wang, Jixia, Zhang, Xiuli, Yu, Ruitao, Liang, Xinmiao. Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 第 5 作者1616: http://dx.doi.org/10.1016/j.chroma.2019.460779.[17] Ahad, Hasanjan, Jin, Hongli, Liu, Yanfang, Wang, Jixia, Sun, Guangying, Liang, Xinmiao, Aisa, Haji Akber. Chemical profiling of spermidines in goji berry by strong cation exchange solid-phase extraction (SCX-SPE) combined with ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS/MS). JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2020, 第 4 作者1137(1): http://dx.doi.org/10.1016/j.jchromb.2019.121923.[18] Qu, Lala, Wang, Jixia, Hou, Tao, Zhou, Han, Wang, Zhiwei, Zhang, Xiuli, Liang, Xinmiao. Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS[J]. 2020, 第 2 作者102: http://dx.doi.org/10.1016/j.vascn.2020.106682.[19] 高振华, 王超然, 郭秀洁, 王纪霞, 郭志谋, 王联芝. 延胡索中叔胺碱和季铵碱类组分的高效分离及镇痛活性鉴定. 天然产物研究与开发[J]. 2020, 第 4 作者32(3): 507-514+419, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=TRCW202003021&v=Mjc2NjBNVC9JZWJHNEhOSE1ySTlIWllSOGVYMUx1eFlTN0RoMVQzcVRyV00xRnJDVVI3cWVadWR1RnlIblZMck0=.[20] 王纪霞. 唐古特山莨菪中大环二咖啡酸亚精胺类新骨架对映异构体Scocycamides的发现及胆碱酯酶抑制与抗氧化的活性研究. Organic Letters. 2020, 第 1 作者[21] Xu, Fangfang, Zhao, Yaopeng, Zhou, Han, Li, Chunzhi, Zhang, Xiuli, Hou, Tao, Qu, Lala, Wei, Lai, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2020, 第 9 作者 通讯作者 30(24): http://dx.doi.org/10.1016/j.bmcl.2020.127650.[22] Zhou, Weijia, Liu, Yanming, Wang, Jixia, Guo, Zhimou, Shen, Aijin, Liu, Yanfang, Liang, Xinmiao. Application of two-dimensional liquid chromatography in the separation of traditional Chinese medicine. JOURNAL OF SEPARATION SCIENCE. 2020, 第 3 作者43(1): 87-104, http://dx.doi.org/10.1002/jssc.201900765.[23] Guo, Xiujie, Gao, Zhenhua, Wang, Jixia, Guo, Zhimou, Zhang, Xiuli, Liu, Yanfang, Wang, Lianzhi, Wang, Chaoran, Liang, Xinmiao. Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separation combined with preparative C18 and silica based strong cation-exchange chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2019, 第 3 作者1126: http://dx.doi.org/10.1016/j.jchromb.2019.121742.[24] Wang, Jixia, Chen, Linlin, Qu, Lala, Li, Kuiyong, Zhao, Yaopeng, Wang, Zhiwei, Li, Yuan, Zhang, Xiuli, Jin, Yu, Liang, Xinmiao. Isolation and bioactive evaluation of flavonoid glycosides from Lobelia chinensis Lour using two-dimensional liquid chromatography combined with label-free cell phenotypic assays. JOURNAL OF CHROMATOGRAPHY A[J]. 2019, 第 1 作者1601: 224-231, http://dx.doi.org/10.1016/j.chroma.2019.04.073.[25] Liu, Dian, Jin, Hongli, Wang, Jixia, Zhou, Han, Liu, Yanfang, Feng, Jiatao, Liang, Xinmiao. Offline preparative 2-D polar-copolymerized reversed-phase chromatography x zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2019, 第 3 作者1118: 70-77, [26] Dian Liu, Hongli Jin, Jixia Wang, Han Zhou, Yanfang Liu, Jiatao Feng, Xinmiao Liang. Offline preparative 2-D polar-copolymerized reversed-phase chromatography × zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori. JOURNALOFCHROMATOGRAPHYB. 2019, 第 3 作者1118-1119: 70-77, http://dx.doi.org/10.1016/j.jchromb.2019.04.039.[27] Wang, Rong, Wang, Jixia, Liu, Yanfang, Zhang, Xiuli, Liang, Xinmiao. Resonant waveguide grating based assays for colloidal aggregate detection and promiscuity characterization in natural products. RSC ADVANCES[J]. 2019, 第 2 作者9(65): 38055-38064, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000501604800042.[28] 王纪霞. 二维液相色谱结合无标记细胞表型法分离半边莲黄酮苷及其生物活性评价. Journal of Chromatography A. 2019, 第 1 作者[29] Xu, Fangfang, Zhou, Han, Liu, Xiumei, Zhang, Xiuli, Wang, Zhiwei, Hou, Tao, Wang, Jixia, Qu, Lala, Zhang, Pengyu, Piao, Hailong, Liang, Xinmiao. Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products. RSC ADVANCES[J]. 2019, 第 7 作者9(26): 15073-15083, http://dx.doi.org/10.1039/c9ra02142f.[30] Zhang, Pengyu, Wang, Jixia, Zhao, Ying, Zhang, Xiuli, Qu, Lala, Wang, Chaoran, Feng, Jiatao, Wang, Anhui, Zhou, Weijia, Liu, Yanfang, Hou, Tao, Zhou, Han, Wang, Zhiwei, Liang, Xinmiao. Discovery of novel antagonists on beta(2)-adrenoceptor from natural products using a label-free cell phenotypic assay. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY[J]. 2018, 第 2 作者391(12): 1411-1420, https://www.webofscience.com/wos/woscc/full-record/WOS:000448849700010.[31] Zhou, Weijia, Wang, Jixia, Zhao, Yaopeng, Yu, Long, Fang, Ye, Jin, Hongli, Zhou, Han, Zhang, Pengyu, Liu, Yanfang, Zhang, Xiuli, Liang, Xinmiao. Discovery of beta(2)-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 第 2 作者1577: 59-65, http://www.corc.org.cn/handle/1471x/2372969.[32] Wang, Jixia, Qi, Huan, Zhang, Xiuli, Si, Wei, Xu, Fangfang, Hou, Tao, Zhou, Han, Wang, Anhui, Li, Guohui, Liu, Yanfang, Fang, Ye, Piao, Hailong, Liang, Xinmiao. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2018, 第 1 作者108: 724-733, http://cas-ir.dicp.ac.cn/handle/321008/166658.[33] Wei, Lai, Hou, Tao, Lu, Chang, Wang, Jixia, Zhang, Xiuli, Fang, Ye, Zhao, Yaopeng, Feng, Jiatao, Li, Jiaqi, Qu, Lala, Piao, Hailong, Liang, Xinmiao. SAR Studies of N-2-(1H-Tetrazol-5-yl)phenylbenzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2018, 第 4 作者9(5): 422-427, https://www.webofscience.com/wos/woscc/full-record/WOS:000432205400006.[34] 王纪霞. 柴胡皂苷D通过靶向β-连环蛋白信号抑制三阴性乳腺癌细胞生长. Biomedicine & Pharmacotherapy. 2018, 第 1 作者[35] 王纪霞. 作为G蛋白偶联受体-35激动剂的2H-色酮衍生物的发现. Journal of Medicinal Chemistry. 2017, 第 1 作者[36] Du, Nana, Liu, Yanfang, Zhang, Xiuli, Wang, Jixia, Zhao, Jianqiang, He, Jian, Zhou, Han, Mei, Lijuan, Liang, Xinmiao. Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica. SCIENTIFIC REPORTS[J]. 2017, 第 4 作者7: http://210.75.249.4/handle/363003/6824.[37] Wei, Lai, Wang, Jixia, Zhang, Xiuli, Wang, Ping, Zhao, Yaopeng, Li, Jiaqi, Hou, Tao, Qu, Lala, Shi, Liying, Liang, Xinmiao, Fang, Ye. Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 第 2 作者60(1): 362-372, http://cas-ir.dicp.ac.cn/handle/321008/151875.[38] Wang, Jixia, Zhang, Xiuli, Li, Xiaolong, Zhang, Yun, Hou, Tao, Wei, Lai, Qu, Lala, Shi, Liying, Liu, Yanfang, Zou, Lijuan, Liang, Xinmiao. Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者6: http://cas-ir.dicp.ac.cn/handle/321008/170770.[39] 侯滔, 史丽颖, 何牮, 王平, 王纪霞, 魏来, 张秀莉, 梁鑫淼. 两个黄酮类化合物对GPR35受体激动活性的研究. 中国科学. 生命科学[J]. 2016, 第 5 作者46(2): 192-198, https://www.sciengine.com/doi/10.1360/N052015-00032.[40] Zhang, Yun, Jin, Hongli, Li, Xiaolong, Zhao, Jianqiang, Guo, Xiujie, Wang, Jixia, Guo, Zhimou, Zhang, Xiuli, Tao, Yanduo, Liu, Yanfang, Chen, Deliang, Liang, Xinmiao. Separation and characterization of bufadienolides in toad skin using two-dimensional normal-phase liquid chromatography x reversed-phase liquid chromatography coupled with mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2016, 第 6 作者1026: 67-74, http://210.75.249.4/handle/363003/6472.[41] Wang, Jixia, Zhang, Xiuli, Fang, Ye, Liang, Xinmiao. Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology. CURRENT PHARMACEUTICAL DESIGN[J]. 2016, 第 1 作者22(21): 3190-3200, http://cas-ir.dicp.ac.cn/handle/321008/170048.[42] Hou, Tao, Shi, Liying, Wang, Jixia, Wei, Lai, Qu, Lala, Zhang, Xiuli, Liang, Xinmiao. Label-free cell phenotypic profiling and pathway deconvolution of neurotensin receptor-1. PHARMACOLOGICAL RESEARCH[J]. 2016, 第 3 作者108: 39-45, http://cas-ir.dicp.ac.cn/handle/321008/170548.[43] Jin, Hongli, Liu, Yanfang, Guo, Zhimou, Wang, Jixia, Zhang, Xiuli, Wang, Chaoran, Liang, Xinmiao. Recent development in liquid chromatography stationary phases for separation of Traditional Chinese Medicine components. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2016, 第 4 作者130: 336-346, http://dx.doi.org/10.1016/j.jpba.2016.06.008.[44] 王纪霞, 侯滔, 魏来, 史丽颖, 何牮, Nan Zhou, 孙广炜, 张秀莉, 梁鑫淼. Discovery of new targets of phenolic acids in Danshen using label-free cell phenotypic assay. RSC ADVANCES[J]. 2016, 第 1 作者5: 25768, http://cas-ir.dicp.ac.cn/handle/321008/148180.[45] 梁鑫淼, 王纪霞, 张秀莉, 方晔. 13 Label-Free Cell Phenotypic Identifi cation of Active Compounds in Traditional Chinese Medicines. LABEL—FREE BIOSENSOR METHODS IN DRUG DISCOVERY[J]. 2016, 第 2 作者233, http://cas-ir.dicp.ac.cn/handle/321008/148025.[46] 闫竞宇, 郭志谋, 丁俊杰, 沈爱金, 王纪霞, 金高娃, 梁鑫淼. 万古霉素及其杂质的亲水作用色谱分析. CHINESE JOURNAL OF CHROMATOGRAPHY色谱[J]. 2015, 第 5 作者33(9): 951-956, http://cas-ir.dicp.ac.cn/handle/321008/148015.[47] Wang, Jixia, Hou, Tao, Wei, Lai, Shi, Liying, He, Jian, Zhou, Nan, Sun, Guangwei, Zhang, Xiuli, Liang, Xinmiao. Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay. RSC ADVANCES[J]. 2015, 第 1 作者5(33): 25768-25776, http://cas-ir.dicp.ac.cn/handle/321008/146110.[48] Jin, Hongli, Liu, Yanfang, Guo, Zhimou, Yang, Fan, Wang, Jixia, Li, Xiaolong, Peng, Xiaojun, Lang, Xinmiao. High-Performance Liquid Chromatography Separation of cis-trans Anthocyanin Isomers from Wild Lycium ruthenicum Murr. Employing a Mixed-Mode Reversed-Phase/Strong Anion-Exchange Stationary Phase. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2015, 第 5 作者63(2): 500-508, http://cas-ir.dicp.ac.cn/handle/321008/146016.[49] 侯滔, 丁辉, 史丽颖, 何牮, 王纪霞, 魏来, 张秀莉, 梁鑫淼. 羟基茜草素对GPR35受体激动活性的研究. 世界科学技术中医药现代化[J]. 2015, 第 5 作者1414-1418, http://lib.cqvip.com/Qikan/Article/Detail?id=666299444.[50] 金红利, 刘艳芳, 郭志谋, 方晔, 王纪霞, 李晓龙, Xiaojun Peng, 梁鑫淼. High-Performance Liquid Chromatography Separation of cis−trans Anthocyanin Isomers from Wild Lycium ruthenicum Murr. Employing a Mixed-Mode Reversed-Phase/Strong Anion-Exchange Stationary Phase. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2015, 第 5 作者63(2): 500, http://cas-ir.dicp.ac.cn/handle/321008/148029.[51] 王纪霞. 色谱柱选择性的评价及在丹参活性化合物分离中的应用. 2015, 第 1 作者[52] 王纪霞, 张秀莉, 杨帆, 金红利, 史丽颖, 周维佳, 刘艳芳, 梁鑫淼. Double Off-line Two-dimensional Liquid Chromatography for Separation and Identification of Compounds in Salvia Miltiorrhiza (Danshen). 世界中医药[J]. 2015, 第 1 作者1(3): 27, http://cas-ir.dicp.ac.cn/handle/321008/148028.[53] Jin, Hongli, Liu, Yanfang, Yang, Fan, Wang, Jixia, Fu, Dongmei, Zhang, Xiuli, Peng, Xiaojun, Liang, Xinmiao. Characterization of anthocyanins in wild Lycium ruthenicum Murray by HPLC-DAD/QTOF-MS/MS. ANALYTICAL METHODS[J]. 2015, 第 4 作者7(12): 4947-4956, http://cas-ir.dicp.ac.cn/handle/321008/146313.[54] 闫竞宇, 郭志谋, 丁俊杰, 沈爱金, 王纪霞, 金高娃, 梁鑫淼. 万古霉素及其杂质的亲水作用色谱分析. 色谱[J]. 2015, 第 5 作者33(9): 951-956, http://lib.cqvip.com/Qikan/Article/Detail?id=665964914.[55] Wang, Jixia, Guo, Zhimou, Shen, Aijin, Yu, Long, Xiao, Yuansheng, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Hydrophilic-subtraction model for the characterization and comparison of hydrophilic interaction liquid chromatography columns. 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Hydrophilic interaction liquid chromatography-solid phase extraction directly combined with protein precipitation for the determination of triptorelin in plasma. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2014, 第 1 作者960: 214-221, http://dx.doi.org/10.1016/j.jchromb.2014.04.036.
发表著作
(1) 基于无标记细胞整合药理学技术鉴定中药的活性化合物, Label-Free Cell Phenotypic Identification of Active Compounds in Traditional Chinese Medicines, Springer, 2015-04, 第 2 作者
科研活动
科研项目
( 1 ) 基于β2和M3靶点-通路的莪术抗慢阻肺活性成分及整合作用机制研究, 主持, 国家级, 2019-01--2021-12( 2 ) 基于本草物质库的ATP柠檬酸裂解酶抑制剂的发现与药效研究, 主持, 市地级, 2020-08--2022-08( 3 ) 辽宁道地药材精准控制技术研究与应用, 参与, 研究所(学校), 2020-01--2022-12( 4 ) 源于中药的抗慢阻肺毒蕈碱受体新药研究, 参与, 市地级, 2019-08--2021-07( 5 ) 基于3D细胞球模型与动态质量重置技术的中药抗三阴性乳腺癌药效物质研究, 主持, 国家级, 2022-01--2025-01
参与会议
(1)Cellular Label-free Integrative Pharmacology (CLIP) Assays Identify Active Compounds in Traditional Chinese Medicines 2022-02-07