Xuefeng Zhou

Xuefeng Zhou

Ph.D.,  Professor

South China Sea Institute of Oceanology
Chinese Academy of Sciences

No.164 West Xingang Rd., Guangzhou 510301, China
Tel: +86 20 89023174; Email: xfzhou@scsio.ac.cn

Research Areas

(1) Isolation, identification and activity screening of marine natural products

(2) Mechanism research and druggability evaluation of Marine lead compounds


1999.09 – 2003.07 
    B.Sc., Tongji Medical College, Huazhong University of Science and Technology, China.
2003.09 – 2008.07 
    Ph.D., Tongji Medical College, Huazhong University of Science and Technology, China.


Work Experience

Research Assistant, Associate Professor (from 2010.12), and Professor (from 2018.12), 

South China Sea Institute of Oceanology, Chinese Academy of Sciences


Visiting scholar in Fenical's Lab, Scripps Institution of Oceanography, University of California at San Diego.



(49) Kunlong Li#, Yu Dai#, Jianglian She, Yanbo Zeng, Hao-fu Dai, Shunlin Ou*, Xuefeng Zhou*, Yonghong Liu*. Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp. Journal of Asian Natural Products Research. Accepted. DOI:10.1080/10286020.2021.1873297

(48) Yu Dai#, Kunlong Li#, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, and Yonghong Liu. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401. Mar. Drugs. 2020, 18, 547.

(47) Yanhui Tan#, Wende Deng#, Yueyang Zhang, Minhong Ke, Binhua Zou, Xiaowei Luo, Jianbin Su, Yiyuan Wang, Jialan Xu, Kutty Selva Nandakumar, Yonghong Liu, Xuefeng Zhou* and Xiaojuan Li*. A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses RANKL-induced osteoclastogenesis and attenuates inflammatory bone destruction. British Journal of Pharmacology. 2020, 177: 4242–4260. (IF 7.73)

(46) Jianjiao Wang#, Zhi Liang#, Kunlong Li, Bin Yang, Yonghong Liu, Wei Fang*, Lan Tang*, Xuefeng Zhou*. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha. Journal of Natural Products. 2020, 83, 1258−1264 (Cover Article)

(45) Jianjiao Wang, Qingyun Peng, Xingang Yao, Yonghong Liu, Xuefeng Zhou*. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. The Journal of Antibiotics. 2020, 73, 585-588.

(44) Li Kunlong, Cai Jian, Su Ziqi, Yang Bin, Liu Yonghong, Zhou Xuefeng*, Huang Jingxia* and Tao Huaming*. Glycosylated Natural

(43) Zhou Xuefeng#,*; Liang Zhi#; Li Kunlong; Fang Wei; Tian Yuanxin; Luo Xiaowei; Chen Yulian; Zhan Zhikun; Zhang Tao; Liao Shengrong; Liu Shuwen; Liu Yonghong; Fenical William; Tang Lan*. Exploring the natural piericidins as anti-renal cell carcinoma agents targeting peroxiredoxin 1. Journal of Medicinal Chemistry, 2019, 62, 70587069.

(42) Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins AD, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry, 2019, 84 (19): 1262612631. (Cover Article)

(41) Wang Jianjiao, Li Kunlong, Luo Xiaowei, Wu Zhaoyuan, Gu Tanwei, Liao Shengrong, Lin Xiuping, Yang Bin, Liu Yonghong, Fang Wei*, Zhou Xuefeng*.Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry, 2019, 17: 87218725. (Cover Article)

(40) Lu Xianyuan, Dong Yaqian, Jian Zhichao, Li Qingyun, Gong Linna, Tang Lan, Zhou Xuefeng*, Liu Menghua*.Systematic investigation of the effects of long-term administration of a high-fat diet on drug transporters in the mouse liver, kidney and intestine. Current Drug Metabolism2019, 20: 742-755

(39) He Jingyu, Dong Yaqian, Liu Xiaoyan, Wan Yiling, Gu Tanwei, Zhou Xuefeng*, Liu Menghua*.Comparison of chemical compositions, antioxidant, and anti-photoaging activities of Paeonia suffruticosa flowers at different flowering stages. Antioxidants, 2019, 8(9), 345.

(38) Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungusAspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers, 2019, 6: 736~740.

(37) Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong*. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines, 2019, 17(2): 149~154.

(36) Lin Xiuping#; Li Kunlong#; Yang Lilin; Peng Xiaoying; Fang Wei; Tian Xinpeng*; Liu Yonghong; Zhou Xuefeng*. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2019, 33(4): 494–499.

(35) Tan Suiyi#; Yang Bin#; Liu Juan; Xun Tianrong; Liu Yonghong; Zhou Xuefeng*. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent. Natural Product Research, 2019, 33(10): 1467-1471.

(34) Wang Jianjiao#; Chen Feimin#; Liu Yunhao; Liu Yuxuan; Li Kunlong; Yang Xiliang; Liu Shuwen*; Zhou Xuefeng*, Yang Jie*. Spirostaphylotrichin X from a marine-derived fungus as an anti-influenza agent targeting RNA polymerase PB2. Journal of Natural Products, 2018, 81(12): 2722~2730.(Top 20 Most Read Articles in December, 2018)

(33) Fang Wei; Wang Jianjiao; Wang Junfeng; Shi Liqiao; Li Kunlong; Lin Xiuping; Min Yong; Yang Bin; Tang Lan; Liu Yonghong; Zhou Xuefeng*. Cytotoxic and antibacterial eremophilane sesquiterpenes from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Journal of Natural Products, 2018, 81(6): 1405~1410.

(32) Luo Xiaowei; Lin Xiuping; Tao Huaming; Wang Junfeng; Li Jiayi; Yang Bin;Zhou Xuefeng*; Liu Yonghong*. Isochromophilones A-F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products, 2018, 81(4): 934~941.

(31) Tan Yanhui#; Yang Bin#; Lin Xiuping; Luo Xiaowei; Pang Xiaoyan; Tang Lan; Liu Yonghong; Li Xiaojuan*; Zhou Xuefeng*. Nitrobenzoyl sesquiterpenoids with cytotoxic activities from a marine-derived Aspergillus ochraceus fungus. Journal of Natural Products, 2018, 81(1): 92~97.

(30) Tian Yongqi; Lin Xiuping; Zhou Xuefeng*; Liu Yonghong*. Phenol derivatives from the sponge-derived fungus Didymellaceae sp. SCSIO F46. Frontiers in Chemistry, 2018, 6: 536.

(29) Luo Xiaowei#; Yang Jie#; Chen Feimin; Lin Xiuping; Chen Chunmei;Zhou Xuefeng*; Liu Shuwen*; Liu Yonghong*. Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry, 2018, 6: 282.

(28) Yang Bin; Tao Huaming; Lin Xiuping; Wang Junfeng; Liao Shengrong; Dong Junde; Zhou Xuefeng*; Liu Yonghong*. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp SCSI0041218.Tetrahedron, 2018, 74(1): 77~82.

(27) Luo Xiaowei; Zhou Xuefeng*; Liu Yonghong*. Nitrogenous compounds produced by the deep sea derived fungus Leptosphaeria sp SCSIO 41005. Natural Product Communications, 2018, 13(6): 677~678.


(26) Lin Xiuping#; Wu Qinyu#; Yu Yuying; Liang Zhi; Liu Yonghong; Zhou Lili*; Tang Lan*; Zhou Xuefeng*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, 7: 10757.

(25) Luo Xiaowei; Lin Xiuping; Salendra Limbadri; Pang Xiaoyan; Dai Yu; Yang Bin; Liu Juan; Wang Junfeng; Zhou Xuefeng*; Liu Yonghong*.Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp SCSIO 41005. Marine Drugs, 2017, 15(7): 204.

(24) Yang Xiliang*; Peng Qingyun; Liu Qian; Hu Jie; Tang Zhipeng; Cui Lianjie; Lin Zonghao; Xu Bing; Lu Kuojian; Yang Fang; Sheng Zhizheng; Yuan Qiong; Liu Song; Zhang Jiuliang; Zhou Xuefeng*.Antioxidant activity against H2O2-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves. Pharmaceutical Biology, 2017, 55(1): 1843~1848.

(23)Zhou Xuefeng#; Fang Wei#; Tan Suiyi#; Lin Xiuping; Xun Tianrong; Yang Bingjie; Liu Shuwen*; Liu Yonghong*. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2): 361~365.

(22)Zhou Xuefeng; Fenical William*. The unique chemistry and biology of the piericidins. Journal of Antibiotics. 2016, 69(8): 582~593.

(21) Fang Wei#; Lin Xiuping#; Wang Jianjiao; Liu Yonghong; Tao Huaming*; Zhou Xuefeng*. Asperpyrone-type bis-naphtho-pyrones with COX-2-inhibitory activities from marine-derived fungus Aspergillus niger. Molecules, 2016, 21: 941.

(20) Fang Wei#; Lin Xiuping#; Zhou Xuefeng*; Wan Junting; Lu Xin; Yang Bin; Ai Wen; Lin Ji; Zhang Tianyu; Tu Zhengchao; Liu Yonghong*. Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17. MedChemComm, 2014, 5(6): 701~705. (Cover Article)

(19) Fredimoses Mangaladoss#;Zhou Xuefeng#; Lin Xiuping; Tian Xinpeng; Ai Wen; Wang Junfeng; Liao Shengrong; Liu Juan; Yang Bin; Yang Xianwen; Liu Yonghong*.New prenylxanthones from the deep-Sea derived fungusEmericella sp. SCSIO 05240. Marine Drugs, 2014, 12(6): 3190~3202.

(18)Zhou Xuefeng; Sun Jianfan; Ma Wanlei; Fang Wei; Chen Zhefan; Yang Bin; Liu Yonghong*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology, 2014, 52(2): 187~190.

(17)Zhou Xuefeng#; Lin Xiuping#; Ma Wanlei; Fang Wei; Chen Zhefang; Yang Bin; Liu Yonghong*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters, 2014, 7: 35~37.

(16)Zhou Xuefeng; Liu Juan; Yang Bin; Lin Xiuping; Yang Xian-Wen; Liu Yonghong*. Marine natural products with anti-HIV activities in the last decade.Current Medicinal Chemistry, 2013, 20(7): 953~973.

(15)Zhou Xuefeng; Lin Xiuping; Guo Xieyang; Yang Bin; Yang Xian-Wen; Liu Yonghong*.Chemical constituents of the sponge Mycalespecies from South China Sea. Records of Natural Products, 2013, 7(2): 119~123.

(14)Zhou Xuefeng; Lu Yanan; Lin Xiuping; Yang Bin; Yang Xian-Wen; Liu Yonghong*. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities. Chemistry and Physics of Lipids, 2011, 164(7): 703~706.

(13)Xuefeng Zhou, Tunhai Xu, Yonghong Liu. Alisma orientale(Sam.) Juzep., a Common Traditional Chinese Medicine Plant as a Diuretic Agent. Recent Progress in Medicinal Plants Vol. 28: Drug Plants II. ISBN:1933699183, Houston: Studium Press LLC, 2010. P461~480.

(12)Zhou Xuefeng; Xu Tunhai; Yang Xian-Wen; Huang Riming; Yang Bin; Tang Lan; Liu Yonghong*. Chemical and biological aspects of marine sponges of the genus Xestospongia. Chemistry and Biodiversity, 2010, 7(9): 2201~2227.

(11)Zhou Xuefeng; Xu Tunhai; Wen Kewei; Yang Xian-Wen; Xu Shi-Hai*; Liu Yonghong*.New N-Acyl taurine from the sea urchin Glyptocidaris crenularis. Bioscience Biotechnology and Biochemistry, 2010, 74(5): 1089~1091.

(10)Zhou Xuefeng; Wen Kewei; Yang Xian-Wen; Huang Riming; Dong Guang; Yang Bin; Liu Yonghong*.Chemical constituents from the sea urchin Glyptocidaris crenularis. Biochemical Systematics and Ecology, 2010, 38(1): 103~105.

(9)Zhou Xuefeng; Liu Yonghong; Tang Lan; Zhang Peng*; Wu Jizhou.Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds, 2010, 46(2): 308~309.

(8)Zhou Xuefeng; Tang Lan*; Liu Yonghong.An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids, 2009, 44(8): 759~763.

(7)Zhou Xue-Feng; Tang Lan; Zhang Peng*; Zhao Xiao-Ya; Pi Hui-Fang; Zhang Yong-Hui; Wu Ji-Zhou.The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var.hupehensis. Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2009, 64(5-6): 369~372.

(6)Zhou Xue-Feng; Zhang Peng*; Pi Hui-Fang; Zhang Yong-Hui; Ruan Han-Li; Wang Hui; Wu Ji-Zhou. Triterpenoids from the roots of Actinidia chinensis. Chemistry and Biodiversity, 2009, 6(8): 1202~1207.

(5) 周雪峰,唐斓,张鹏,阮汉利,张勇慧,皮慧芳,吴继洲. 冷水七单体皂苷抗炎镇痛和免疫活性研究.中药药理与临床.2008, 24(1):27~28.

(4)Zhou Xue-Feng; Tang Lan; Zhang Yong-Hui; Pi Hui-Fang; Ruan Han-Li; Wu Ji-Zhou*. Nitrogenous compounds from Impatiens pritzellii var. hupehensis (Balsaminaceae). Biochemical Systematics and Ecology2007, 35(5): 308~310.

(3)Zhou Xue-Feng; Zhao Xiao-Ya; Tang Lan; Zhang Yong-Hui; Ruan Han-Li; Pi Hui-Fang; Qiu Jun; Wu Ji-Zhou*. Immunomodulatory activity of the rhizomes ofImpatiens pritzellii var.hupehensison collagen-induced arthritis mice. Journal of Ethnopharmacology, 2007, 109(3): 505~509. (2Top)

(2)Zhou Xue-Feng; Zhao Xiao-Ya; Tang Lan; Ruan Han-Li; Zhang Yong-Hui; Pi Hui-Fang; Xiao Wei-Lie; Sun Han-Dong; Wu Ji-Zhou*.Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis. Journal of Asian Natural Products Research, 2007, 9(4): 379~385.

(1)周雪峰,尹仁杰,阮汉利,张勇慧,皮慧芳,赵晓亚,吴继洲.泽泻抑制尿草酸钙结石形成活性成分的2D NMR分析.波谱学杂志, 2005, 22(2):195~200.


Students considering graduate research in marine natural products (master’s degree) are encouraged to contact Dr. Xuefeng Zhou.

There are also opportunities for undergraduate students to do research in marine natural products under the guidance of Dr. Xuefeng Zhou.