药物先导分子的发现与优化

  

（1）新型抗血小板活性分子的发现、设计、合成及其抗血栓活性研究

（2）基于天然产物“优势骨架”和药物“活性片段”的类药性化学空间的构建及其生物活性研究

​100701-药物化学

2017-09--2020-06   云南大学   博士
2013-09--2016-06   昆明医科大学   硕士
2009-09--2013-06   湖北医药学院药护学院   学士

   

2024-02~现在, 中国科学院昆明植物研究所, 副研究员
2022-06~2024-02,中国科学院昆明植物研究所, 助理研究员
2020-07~2022-06,中国科学院昆明植物研究所, 博士后
2016-07~2017-08,中国科学院昆明植物研究所, 实习研究员

   

（1） “兴滇英才”支持计划青年人才称号, , 省级, 2023
（2） 博士研究生国家奖学金, 部委级, 2019

[1] 许刚, 赵金华, 夏凡, 林丽莎. 松香烷型二萜类化合物在制备预防和/或治疗血栓性疾病的药物中的应用. CN: CN110840867B, 2021-12-21.
[2] 许刚, 赵金华, 夏凡, 林丽莎. 松香烷型二萜类化合物及其制备方法、具有抗血小板活性的药物组合物及其应用. CN: CN110922384B, 2021-09-28.
[3] 秦红波, 许刚, 李成季, 夏凡. 丹参新酮和去氢丹参新酮的制备方法. CN: CN108558626A, 2018-09-21.
[4] 许刚, 秦红波, 夏凡, 李成季. 丹参新酮衍生物及其药物组合物与其在制药中的应用. CN: CN108047020A, 2018-05-18.
[5] 许刚, 纪旭, 夏凡, 罗丹. 系列开环松香烷型二萜类化合物及其药物组合物与其在制药中的应用. CN: CN107746403A, 2018-03-02.

   

[1] Fan Xia, LiSha Lin, YanSong Ye, Lian Yang, JinHua Zhao, Gang Xu. 11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii. BIOORGANIC CHEMISTRY. 2023, 第 1 作者140: http://dx.doi.org/10.1016/j.bioorg.2023.106834.
[2] Xia Fan, Du Shuzong, Wu Mingkun, Liu Rui, Ye Yansong, Yang Jian, Xu Gang, Nian Yin. Icetexane Diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and Analgesic Effect of Their Semi-synthesized Derivatives. BIOORGANIC CHEMISTRY[J]. 2022, 第 1 作者http://dx.doi.org/10.1016/j.bioorg.2022.106059.
[3] Xia, Fan, Luo, Dan, Wang, Tingting, Ji, Xu, Xu, Gang. Vasorelaxant 4,5-seco-abietane diterpenoids with diverse 6/6/6, 6/6/7, and 6/6/8 architectures from Salvia prattii Hemsl.. FITOTERAPIA[J]. 2020, 第 1 作者142: http://dx.doi.org/10.1016/j.fitote.2020.104521.
[4] Xia, Fan, Li, WenYan, Yang, XingWei, Yang, Jian, Li, Xian, Nian, Yin, Xu, Gang. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii. ORGANIC LETTERS[J]. 2019, 第 1 作者21(14): 5670-5674, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957200062.
[5] Chen, WenFei, Wong, LaiLai, Zhang, Xuan, Zhou, FengXu, Xia, Fan, Tang, LiPing, Li, Xian. New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara. CHEMISTRY & BIODIVERSITY[J]. 2019, 第 5 作者  通讯作者  16(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000471923800019.
[6] Hu, YaLi, Hu, Kun, Kong, LingMei, Xia, Fan, Yang, XingWei, Xu, Gang. Norascyronones A and B, 2,3,4-nor-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum ascyron. ORGANIC LETTERS[J]. 2019, 第 4 作者21(4): 1007-1010, http://ir.kib.ac.cn/handle/151853/64640.
[7] Li, MingMing, Xia, Fan, Li, ChengJi, Xu, Gang, Qin, HongBo. Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives. TETRAHEDRON LETTERS[J]. 2018, 第 2 作者59(1): 46-48, http://dx.doi.org/10.1016/j.tetlet.2017.11.046.
[8] Li, ChengJi, Xia, Fan, Zhang, Wen, Wang, Kou, Xu, Gang, Qin, HongBo. Semisynthesis of miltirone, 1,2-dehydromiltirone, saligerone from carnosic acid and cytotoxities of their derivatives. TETRAHEDRON LETTERS[J]. 2018, 第 2 作者59(26): 2607-2609, http://ir.kib.ac.cn/handle/151853/64727.
[9] Li, Cheng-Ji, Xia, Fan, Zhang, Wen, Wang, Kou, Xu, Gang, Qin, Hong-Bo. Semisynthesis of miltirone, 1,2-dehydromiltirone, saligerone from carnosic acid and cytotoxities of their derivatives. FRONTIERS IN PHARMACOLOGY[J]. 2018, 第 2 作者9: 673, http://ir.kib.ac.cn/handle/151853/63354.
[10] Xia, Fan, Zhang, DaWei, Wu, ChunYan, Geng, HuiChun, Xu, WenDan, Zhang, Yu, Yang, XingWei, Qin, HongBo, Xu, Gang. Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 第 1 作者5(8): 1262-1266, http://dx.doi.org/10.1039/c7qo01140g.
[11] Fan Xia, Da-Wei Zhang, Chun-Yan Wu, Hui-Chun Geng, Wen-Dan Xu, Yu Zhang, Xing-Wei Yang, Hong-Bo Qin, Gang Xu. Isolation, structural elucidation, and synthetic studies of salviyunnanone A, an abietane derived diterpenoid with 7/5/6/3 ring system from Salvia yunnanensis. Org. Chem. Front.[J]. 2018, 第 1 作者
[12] Yang, XingWei, Wang, Huan, Ma, WeiGuang, Xia, Fan, Xu, Gang. homo-adamantane type polyprenylated acylphloroglucinols from Hypericum pseudohenryi. TETRAHEDRON[J]. 2017, 第 4 作者73(5): 566-570, http://dx.doi.org/10.1016/j.tet.2016.12.042.
[13] Kong, LingMei, Long, XianWen, Yang, XingWei, Xia, Fan, Khan, Afsar, Yan, Hui, Deng, Jun, Li, Xian, Xu, Gang. seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron. TETRAHEDRON LETTERS[J]. 2017, 第 4 作者58(22): 2113-2117, http://dx.doi.org/10.1016/j.tetlet.2017.04.044.
[14] Li, YanPing, Yang, XingWei, Xia, Fan, Yan, Hui, Ma, WeiGuang, Xu, Gang. Hyperjapones F-I, terpenoid polymethylated acylphloroglucinols from Hypericum japonicum. TETRAHEDRON LETTERS[J]. 2016, 第 3 作者57(52): 5868-5871, http://dx.doi.org/10.1016/j.tetlet.2016.11.058.
[15] Yang, XingWei, Yang, Jing, Liao, Yang, Ye, Ye, Li, YanPing, Yang, ShuYa, Xia, Fan, Xu, Gang. Hypercohin K, a polycyclic polyprenylated acylphloroglucinol with an unusual spiro-fused cyclopropane ring from Hypericum cohaerens. TETRAHEDRON LETTERS[J]. 2015, 第 7 作者56(41): 5537-5540, http://dx.doi.org/10.1016/j.tetlet.2015.08.033.
[16] Fan Xia, Chun-Yan Wu, Xing-Wei Yang, Xian Li, Gang Xu. Diterpenoids from the Roots of Salvia yunnanensis. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2015, 第 1 作者5(6): 307-12, http://ir.kib.ac.cn/handle/151853/64901.

   

（ 1 ） 新颖抗血小板活性松香烷二萜的结构优化与作用机制研究, 负责人, 国家任务, 2022-01--2024-12
（ 2 ） 抗血小板活性松香烷二萜的构效关系和作用机制研究, 负责人, 国家任务, 2020-11--2022-07
（ 3 ） 红根草中4, 5-开环型松香烷二萜的挖掘与心血管活性研究, 负责人, 地方任务, 2024-06--2027-05
（ 4 ） 基于松香烷型二萜类分子探针的合成及其抗血小板机制研究, 负责人, 地方任务, 2023-06--2026-05
（ 5 ） 新型血小板抑制剂治疗动脉血栓的创新药物研究, 负责人, 地方任务, 2024-01--2028-12