基本信息

周欣  男  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: xinzhou@wipm.ac.cn
通信地址: 武汉市小洪山西区30号波谱楼1908室
邮政编码: 430071


导师简介

周欣,基金委创新研究群体项目负责人、杰青、国家“特支计划”领军人才,担任基金委国家重大科研仪器设备研制项目专家委员会委员,中国物理学会波谱专业委员会常务副主任委员。获全国创新争先奖、中科院年度创新人物、首届科学探索奖、CCTV“全国十大科技创新人物”、中科院青年科学家奖、湖北省技术发明一等奖等荣誉。

主要从事医学影像的新仪器、新技术及活体分子成像方面的研究。自主研制了世界上增强倍数最高的人体肺部气体磁共振(MRI)仪器,成功“点亮”肺部,有效解决了肺部无损、定量、可视化检测瓶颈技术背后的科学难题;发展了多核MRI新技术,研制了系列新型造影剂,为脑部重大疾病和肿瘤的早期检测提供了全新的医学影像仪器与手段。在PNAS、Science子刊等学术刊物上发表论文百余篇,授权及受理国内外发明专利百余件。


研究领域

1、Hyperpolarized Instruments


The principle that enables researchers to generate hyperpolarization in gases (e.g. hyperpolarized 129Xe or 3He) via spin exchange collisions. The collisions are mainly binary collisions that depend on thermal velocity at high pressures and also short-lived van der Waals interactions or three-body collisions that depend on the partial pressure at low pressure.

The basic structure diagram of the 129Xe hyperpolarizer is shown above.  It features an optical cell used for optical pumping and spin-exchange collisions, collection system, gas supply system, vacuum system.  A computer is used for monitoring and controlling the process.




2、MRI Methods and Techniques for the Lung


Left image shows conventional proton MR image of lung.  The signal originates from the lung's H2O content (about 10^22 hydrogen atoms).

Right image shows a hyperpolarized MR image of lung.  The signal originates from helium (3He) gas (about 10^10 atoms).


Lung diseases, especially lung cancer, are a major cause of human death.Thus, imaging techniques that can help identify the onset, type and grade of disease at an early stage is critical.  Lungs are normally imaged by x-ray techniques (2D and CT).  However, these techniques rely on ionizing radiation, which represents an additional health risk, and do not provide any information that can help assess the function of the lung. The latter is important because an accurate diagnosis should interrogate not only its structure, but whether or not the lung functions (e.g. ventilates) well.


Conventional MRI, based on the use of proton signal, can depict structure and function of brain and other organs, but cannot image lung.  This is because the lung consists of:

    1) much void space filled with air, which does not yield detectable signal, and

    2) its tissue is made of alveolae, which have a very low proton density and short relaxation times due to their porous structure.


In recent years, the technique of hyperpolarized nobles gas MRI has enabled amplifications of the NMR signal by orders of magnitude compared to that of thermal equilibrium.  This technique is an excellent tool for the study of lung by MRI and has excellent potential for the diagnosis of lung diseases by measuring associated changes in the lung's structure and function.


Our team develops NMR and MRI techniques based on hyperpolarized noble gases to quantify the changes in lung structure and function associated with various lung diseases.  This will, in turn, benefit the medical profession and public health by offering new possibilities for early and accurate diagnosis.




3、Hyperploarized Xenon Molecular Sensors and Molecular Imaging


Hyperpolarized 129Xe MRI has emerged in recent years as one of the most powerful methods for molecular imaging with the development of molecular sensors based on xenon. Hyperpolarized 129Xe nuclei offer unprecedented sensitivity enhancement, along with excellent chemical shift sensitivity for detection of molecular events and chemical substances.   This offers new possibilities for molecular imaging.


Our lab is developing various 129Xe-cryptophane biosensors targeted to cancer cells, proteins, and ions.  We are also developing pH- and temperature-sensitive biosensors for in vivo sensing, thereby expanding the capabilities of Xe biosensors.


Another research direction exploits the rapid and reversible encapsulation of Xe between "bound" (i.e., cryptophane) and "free" (i.e., bulk water) states to report additional information for in vitro and in vivo studies of local chemical environments. Our xenon biosensor developments, which include high detection sensitivity, improve medical diagnostic imaging technology while targeting a broad range of biomedical applications.







4、Atomic Magnetometry and Laser-Detected NMR


Nuclear magnetic resonance (NMR) is a powerful analytical technique that has been used not only in fundamental physics, chemistry and biology research, but also in applications such as medical imaging and oil well logging. However, the detection sensitivity of conventional NMR techniques is poor, especially in low magnetic fields. The conventional method of detection is Faraday induction. Low field NMR and MRI are attractive from the point of view of developing simpler (e.g. smaller), more mobile and less costly instrumentation that does not rely on cryogenic superconducting magnet technology.    Thus, much effort is devoted toward improving detection sensitivity. Our group is developing novel NMR detection technology based on optical atomic magnetometry. Optical magnetometers are usually operated at low magnetic fields and become significantly cheaper and more portable than conventional NMR instruments. This provides an interesting alternative approach for low-field NMR.


Our recent work includes a Cs atomic magnetometer with a sensitivity of 150 fT/Hz1/2 operating near room temperature. The NMR signal of a 125 uL water sample was detected in magnetic fields as low as 47 nT, with a signal-to-noise ratio close to 50 after only eight signal averages. To demonstrate the magnetometer's ability to measure spin-lattice relaxation times, relaxivity experiments using a Gd(DTPA) MRI contrast agent were performed near zero field.


In contrast with Faraday induction detection, our zero-field atomic magnetometer is particularly sensitive in the frequency range from DC to a few kilohertz. NMR in low fields does not require the cryogenics needed to operate superconducting magnets. Cryogens are also needed to operate magnetic sensors based on a superconducting quantum interference devices.


Moreover, because magnetic-field gradients are proportional to the magnetic field, operation in ultra low fields implies that the "external field" can be made extremely homogenous. Homogeneous fields lead to very narrow resonance lines, permitting the measurement of ultra weak spin interactions. The prospect of "pure J coupling" NMR in ultra low fields, where chemical shifts are much weaker, has been recognized by several leading research groups.


As a result, this kind of magnetometer makes NMR increasingly more powerful and accessible to a wider range of applications that involve chemical analysis. Our is focusing its research efforts on the development a new class of SERF magnetometers based on Cs vapor and the understanding spectra in low fields for purposes of ultra sensitive chemical detection.



招生信息

   
招生专业
070302-分析化学
070208-无线电物理
083100-生物医学工程
招生方向
生物医学分子影像
肺部磁共振成像仪器与技术
激光探测磁共振

教育背景

1999-09--2004-06   中国科学院武汉物理与数学研究所   博士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2009-10~现在, 中国科学院精密测量科学与技术创新研究院, 研究员
2007-09~2009-09,美国加州大学伯克利分校;美国劳伦斯国家实验室, 研究助理
2005-01~2007-09,美国哈佛大学,美国Brigham Women's Hospital, 博士后
2004-07~2004-12,中国科学院武汉物理与数学研究所, 助理研究员

专利与奖励



奖励与荣誉

(1) 全国创新争先奖, 国家级, 2020 

(2) 中国科学院年度创新人物, 院级, 2020 

(3) 首届科学探索奖, 其他, 2019 

(4)“国家高层次人才特殊支持计划”科技创新领军人才 , 国家级, 2019 

(5) 湖北省技术发明一等奖, 一等奖, 省级, 2018 

(6) 国家科技部“创新人才推进计划”中青年科技创新领军人才, 国家级, 2018 

(7) 2018年度CCTV“全国科技十大创新人物”, 国家级, 2018 

(8) 中国专利优秀奖, 其他, 2017 

(9) 全国王天眷波谱学奖, 其他, 2016 

(10) 中国科学院青年科学家奖, 院级, 2016 

(11) 湖北五一劳动奖章, 省级, 2016 

(12) 中国专利优秀奖, 其他, 2016 

(13) 2015年度湖北十大科技事件, 省级, 2015 

(14)“国家高层次人才特殊支持计划”青年拔尖人才, 国家级, 2014 

(15) 武汉市优秀青年科技工作者, 市地级, 2014 

(16) 中国产学研合作创新成果奖, 其他, 2013

专利成果

(1) 周欣;孙献平;赵修超;刘买利;叶朝辉,Optical-Fiber Atomic Light-Filtering Apparatu;一种光纤原子滤光装置,美国专利,US10795171B22020.10.06

(2) 周欣;韩叶清;孙献平;石磊;刘买利;叶朝辉,Device Having Inert Gas Nucleus Channel and Method for Magnetic Resonance Imaging Using the Same,一种惰性气体原子核通道装置及磁共振成像方法美国专利,US10705169B22020.07.07

(3) 周欣;孙献平;赵修超;刘买利;叶朝辉,一种光纤原子滤光装置,日本专利,JP67004722020.05.07

(4) 周欣;唐德港;石磊;韩叶清;孙献平,一种高介电常数的超高场动物磁共振射频探头,发明,ZL202011023656.72022.06.17

(5) 周欣;李梓萌;肖洒;王成;孙献平;叶朝辉,多任务复值深度学习的欠采样肺部气体MRI重建方法,发明,ZL202110748843.X2022.06.07

(6) 周欣;袁晨露;郭茜旎;孙献平;刘买利;叶朝辉,一种可以递送疏水性药物的超极化129Xe磁共振分子探针,发明,ZL201910310191.42021.11.19

(7) 周欣;曾庆斌;郭茜旎;孙献平;刘买利,一种沸石咪唑骨架材料在磁共振成像中的应用,发明,ZL201810481432.72021.10.08

(8) 周欣;袁亚平;郭茜旎;孙献平;叶朝辉,使用绝热射频脉冲测量射频B1场分布的磁共振成像方法,发明,ZL201911151143.12020.08.11

(9) 周欣;单海威;石磊;孙献平;张许;叶朝辉;刘买利,一种用于极化转移增强技术的多核磁共振射频通道装置,发明,ZL201910041660.72020.06.19

(10) 周欣;肖洒;邓鹤;段曹辉;孙献平;叶朝辉,一种自适应高欠采样超极化气体肺部动态MRI重建方法,发明,ZL201810993635.42020.06.19

(11) 周欣;谢军帅;孙献平;叶朝辉;韩叶清,一种用于肺部动态磁共振成像的便携式呼吸装置及方法,发明,ZL201811135324.02020.06.19

(12) 周欣;谢军帅;李海东;张会婷;孙献平;叶朝辉,一种用于人体肺部的快速功能磁共振成像方法,发明,ZL201710405589.72019.08.16

(13) 周欣;孙献平;赵修超;刘买利;叶朝辉,一种光纤原子滤光装置,发明,ZL201610602759.62019.01.11

(14) 周欣;肖洒;邓鹤;孙献平;叶朝辉,一种基于变采样率的肺部超极化气体动态成像方法,发明,ZL201610743164.22018.12.25

(15) 周欣;张鸣;石磊;孙献平;叶朝辉;刘买利,一种用于超极化气体磁共振成像系统的肺部射频线圈背心,发明,ZL201610870771.52018.10.12

(16) 周欣;刘莲花;陈世桢;孙献平;刘买利,一种近红外氮杂氟硼二吡咯染料及其微波法合成方法,发明,ZL201510534389.22018.04.10

(17) 周欣;杨玉琪;陈世桢;孙献平;刘买利,一种微波法制备多色荧光石墨烯量子点的方法,发明,ZL201410778272.42016.06.15

(18) 周欣;李海东;孙献平;叶朝辉;韩叶清;张智颖,一种非麻醉状态下人体超极化气体呼吸装置,发明,ZL201310301919.X2016.01.20

(19) 周欣;孙献平;赵修超;叶朝辉;刘买利,一种激光预极化固态氙的升华装置,发明,ZL201410096987.12016.01.20

(20) 周欣;孙献平;刘买利;叶朝辉,一种永磁极化器,发明,ZL201110357356.72014.03.12


出版信息

   
发表著作
(1) In vivo NMR Imaging: Methods and Protocols--Hyperpolarized Noble Gases as Contrast Agents, Humana, 2011-10, 第 1 作者
(2) 脑成像的先进技术:超极化氙脑部磁共振成像, Advances in Brain Imaging-Hyperpolarized Xenon Brain MRI , InTech, 2012-01, 第 1 作者
发表论文

[1]  Shizhen Chen , Yina Lan, Haidong Li, Liming Xia, Chaohui Ye, Xin Lou*, Xin Zhou*. Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized 129Xe-MRI-based 8-Month Follow-Up. Biomedicines, Vol 10(4), 781-789. (2022).

[2]  Cheng Wang, Haidong Li, Sa Xiao, Zimeng Li, Xiuchao Zhao, Junshuai Xie, Chaohui Ye, Liming Xia, Xin​ Lou, Xin Zhou*. Abnormal Dynamic Ventilation Function of COVID-19 Survivors Detected by Pulmonary Free-Breathing Proton MRI. European Radiology, DOI: 10.1007/s00330-022-08605-w. (2022).

[3]  Caohui Duan, He Deng, Sa Xiao, Junshuai Xie, Haidong Li, Xiuchao Zhao, Dongshan Han, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Accelerate Gas Diffusion-Weighted MRI for Lung Morphometry with Deep Learning. European Radiology, Vol 32, 702-713. (2022).

[4]  Qingbin Zeng, Qianni Guo, Yaping Yuan, Baolong Wang, Meiju Sui, Xin Lou, Louis-S. Bouchard, Xin Zhou*. Ultrasensitive Molecular Building Block for Biothiol NMR Detection at Picomolar Concentrations. iScience, Vol 24(12), 103515. (2021).

[5]  Weiping Jiang, Qianni Guo, Qing Luo, Xiaoxiao Zhang, Yaping Yuan, Haidong Li, Xin Zhou*. Molecular Concentration Determination Using Long-Interval Chemical Exchange Inversion Transfer (CEIT) NMR Spectroscopy. The Journal of  Physical Chemistry Letters, Vol 12, 8652-8657. (2021).

[6]  Maohua Zhu, Li Wang, Jun Guo, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Improvement in the Signal Amplitude and Bandwidth of an Optical Atomic Magnetometer via Alignment-to-Orientation Conversion. Optics Express, Vol 29(18), 28680-28691. (2021).

[7]  Qian Zhou, Qiuchen Rao, Haidong Li, Ming Zhang, Xiuchao Zhao, Lei Shi, Chaohui Ye, Xin Zhou*. Evaluation of Injuries Caused by Coronavirus Disease 2019 Using Multi-Nuclei Magnetic Resonance Imaging. Magnetic Resonance Letters, Vol 1(1), 2-10. (2021).

[8]  Cheng Wang, Lu Huang, Sa Xiao, Zimeng Li, Chaohui Ye, Liming Xia*, Xin Zhou*. Early Prediction of Lung Lesion Progression in COVID-19 Patients with Extended CT Ventilation Imaging. European Journal of Nuclear Medicine and Molecular Imaging, Vol 48, 4339-4349. (2021).

[9]  Longhui Zhao, Qianni Guo, Chenlu Yuan, Sha Li, Yaping Yuan, Qingbin Zeng, Xu Zhang, Chaohui Ye, Xin Zhou*. Photosensitive MRI Biosensor for BCRP-Targeted Uptake and Light-Induced Inhibition of Tumor Cells. Talanta, Vol 233, 122501. (2021).

[10]        Yuqi Yang, Yingfeng Zhang, Baolong Wang, Qianni Guo, Yaping Yuan, Weiping Jiang, Lei Shi, Minghui Yang, Shizhen Chen, Xin Lou, Xin Zhou*. Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks. Chemical Science, Vol 12(12), 4300-4308. (2021).

[11]  Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129Xe MRI. Science Advances, Vol 7(1), eabc8180. (2021).

[12]  Sha Li, Weiping Jiang, Yaping Yuan, Meiju Sui, Yuqi Yang, Liqun Huang, Ling Jiang, Maili Liu, Shizhen Chen*, Xin Zhou*. Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, Vol 12(51), 57290-57301. (2020).

[13]  高家红*,雷皓,陈群,杜一平,梁栋,卓彦,龚启勇,周欣. 磁共振成像发展综述. 中国科学: 生命科学,Vol 50(11), 1285-1295. (2020).

[14]  骆清铭*,周欣, 叶朝辉*. 生物医学影像学科发展现状和展望. 中国科学:生命科学,Vol 50(11), 1158-1175. (2020).

[15]  叶朝辉*,骆清铭*,周欣*. 影像揭示生命奥秘. 中国科学:生命科学,Vol 50(11), 1155-1157.

[16]  Lili Ren, Shizhen Chen*, Weiping Jiang, Qingbin Zeng, Xu Zhang, Long Xiao, Michael T. McMahon, Xin Lou, Xin Zhou*. Efficient Temperature-feedback Liposome for 19F MRI Signal Enhancement. Chemical Communications, Vol 56(92), 14427-14430. (2020).

[17]  Kangda Xiao, Li Wang, Jun Guo, Maohua Zhu, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Quieting an Environmental Magnetic Field without Shielding. Review of Scientific Instruments, Vol 91(8), 085107. (2020).

[18]  Qingbin Zeng, Binglin Bie, Qianni Guo*, Yaping Yuan, Qi Han, Xiaocang Han, Mingwei Chen, Xu Zhang, Yunhuang Yang, Maili Liu, Pan Liu, Hexiang Deng*, Xin Zhou*. Hyperpolarized Xe NMR Signal Advancement by Metal-organic Framework Entrapment in Aqueous Solution. Proceedings of the National Academy of Sciences of the United States of America, Vol 117(30), 17558-17563. (2020).

[19]  Huaibin Zhang, Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou*, Shizhen Chen*, Zhongxing Jiang*. Fluorinated Porphyrin-Based Theranostics for Dual Imaging and Chemo-Photodynamic Therapy. Journal of Materials Chemistry B, Vol 8(20), 4469-4474. (2020).

[20]  Yaping Yuan, Qianni Guo, Xiaoxiao Zhang, Weiping Jiang, Chaohui Ye, Xin Zhou*. Silica Nanoparticle Coated Perfluorooctyl Bromide for Ultrasensitive MRI. Journal of Materials Chemistry B, Vol 8(23), 5014-5018. (2020).

[21]  Yiqi Hu, He Deng, Lu Huang, Liming Xia, Xin Zhou*. Analysis of Characteristics in Death Patients with COVID-19 Pneumonia without Underlying Diseases. Academic Radiology, Vol 27(5), 752. (2020).

[22]  Qingbin Zeng, Qianni Guo, Yaping Yuan, Xiaoxiao Zhang, Weiping Jiang, Sa Xiao, Bin Zhang, Xin Lou, Chaohui Ye, Maili Liu, Louis-S. Bouchard, Xin Zhou*. A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy. ACS Applied Bio Materials, Vol 3(3), 1779-1786. (2020).

[23]  Ming Zhang, Haidong Li, Hongchuang Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yeqing Han, Yina Lan, He Deng, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Lung Injury Caused by PM2.5 Using Hyperpolarized Gas Magnetic Resonance. Magnetic Resonance in Medicine, Vol 84, 569-578. (2020).

[24]  Caohui Duan, He Deng, Sa Xiao, Junshuai Xie, Haidong Li, Xianping Sun, Lin Ma, Xin Lou, Chaohui Ye, Xin Zhou*. Fast and Accurate Reconstruction of Human Lung Gas MRI with Deep Learning. Magnetic Resonance in Medicine, Vol 82(6), 2273-2285. (2019).

[25]  Lianhua Liu, Yaping Yuan, Yuqi Yang, Michael McMahon, Shizhen Chen*, Xin Zhou*. A Fluorinated Aza-BODIPY Derivative for NIR fluorescence/PA/19F MR Tri-modality In Vivo Imaging. Chemical Communications, Vol 55(42), 5851-5854. (2019).

[26]  Xiaoxiao Zhang, Yaping Yuan, Sha Li, Qingbin Zeng, Qianni Guo, Na Liu, Minghui Yang, Yunhuang Yang, Maili Liu, Michael T. McMahon, Xin Zhou*. Free-Base Porphyrins as CEST MRI Contrast Agents with Highly Upfield Shifted Labile Protons. Magnetic Resonance in Medicine, Vol 82, 577-585. (2019).

[27]  Junshuai Xie, Haidong Li, Huiting Zhang, Xiuchao Zhao, Lei Shi, Ming Zhang, Sa Xiao, He Deng, Ke Wang, Hao Yang, Xianping Sun, Guangyao Wu, Chaohui Ye, Xin Zhou*. Single Breath‐Hold Measurement of Pulmonary Gas Exchange and Diffusion in Humans with Hyperpolarized 129Xe MR. NMR in Biomedicine, Vol 32, e4068. (2019).

[28]  He Deng, Caohui Duan, Sa Xiao, Junshuai Xie, Huiting Zhang, Xianping Sun, Xin Zhou*. k-Space-Based Enhancement of Pulmonary Hyperpolarized 129Xe Ventilation Images. IEEE Transactions on Instrumentation and Measurement, Vol 68(10), 3950-3961. (2019).

[29]  Huaibin Zhang, Shizhen Chen, Yaping Yuan, Yu Li, Zhongxing Jiang*, Xin Zhou*. Xe Hyper-CEST/F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection. ACS Applied Bio Materials, Vol 2(1), 27-32. (2019).

[30]  Yuqi Yang, Shizhen Chen, Haidong Li, Yaping Yuan, Zhiying Zhang, Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. Nano Letters, Vol 19(1), 441-448. (2019).

[31]  He Deng, Xianping Sun, Xin Zhou*. A Multiscale Fuzzy Metric for Detecting Small Infrared Targets Against Chaotic Cloudy/Sea-Sky Backgrounds. IEEE Transactions on Cybernetics, Vol 49(5), 1694-1707. (2019).

[32]  Sa Xiao, He Deng, Caohui Duan, Junshuai Xie, Haidong Li, Xianping Sun, Chaohui Ye, Xin Zhou*. Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI. IEEE Transactions on Medical Imaging, Vol 38(5), 1240-1250. (2019).

[33]  Bin Zhang, Qianni Guo, Qing Luo, Xiaoxiao Zhang, Qingbin Zeng, Longhui Zhao, Yaping Yuan, Weiping Jiang, Yunhuang Yang, Maili Liu, Chaohui Ye, Xin Zhou*. An Intracellular Diamine Oxidase Triggered Hyperpolarized 129Xe Magnetic Resonance Biosensor. Chemical Communications, Vol 54(97), 13654-13657. (2018).

[34]  Haidong Li, Zhiying Zhang, Xiuchao Zhao, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Pulmonary Gas-Exchange Function using Hyperpolarized 129Xe CEST MRS and MRI. NMR in Biomedicine, Vol 31(9), e3961. (2018).

[35]  Sha Li, Yaping Yuan, Yuqi Yang, Conggang Li, Michael T. McMahon, Maili Liu, Shizhen Chen*, Xin Zhou*. Potential Detection of Cancer with Fluorinated Silicon Nanoparticles in 19F MR and Fluorescence Imaging. Journal of Materials Chemistry B, Vol 6, 4293-4300. (2018).

[36]  Huiting Zhang, Junshuai Xie, Sa Xiao, Xiuchao Zhao, Ming Zhang, Lei Shi, Ke Wang, Guangyao Wu, Xianping Sun, Chaohui Ye, Xin Zhou*. Lung Morphometry using Hyperpolarized 129Xe Multi-b Diffusion MRI with Compressed Sensing in Healthy Subjects and Patients with COPD. Medical Physics, Vol 45(7), 3097-3108. (2018).

[37]  Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, Shizhen Chen*, Xin Zhou*. pH-responsive Theranostic Nanocomposites as Synergistically Enhancing Positive and Negative Magnetic Resonance Imaging Contrast Agents. Journal of Nanobiotechnology, Vol 16(30). (2018).

[38]  Shengjun Yang, Qingbin Zeng, Qianni Guo, Shizhen Chen, Hongbin Liu, Maili Liu, Michael T. McMahon, Xin Zhou*. Detection and Differentiation of Cys, Hcy and GSH Mixtures by 19F NMR Probe. Talanta, Vol 184, 513-519. (2018).

[39]  Sa Xiao, He Deng, Caohui Duan, Junshuai Xie, Huiting Zhang, Xianping Sun, Chaohui Ye, Xin Zhou*. Considering Low-Rank, Sparse and Gas-Inflow Effects Constraints for Accelerated Pulmonary Dynamic Hyperpolarized 129Xe MRI. Journal of Magnetic Resonance, Vol 290, 29-37. (2018).

[40]  Yuqi Yang, Shizhen Chen, Lianhua Liu, Sha Li, Qingbin Zeng, Xiuchao Zhao, Haidong Li, Zhiying Zhang, Louis-S. Bouchard, Maili Liu, Xin Zhou*. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS Applied Materials & Interfaces, Vol 9(28), 23400-23408. (2017).

[41]  Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Simultaneous Assessment of Both Lung Morphometry and Gas Exchange Function within a Single Breath-hold by Hyperpolarized 129Xe MRI. NMR in Biomedicine, Vol 30(8), e3730. (2017).

[42]  Shengjun Yang, Yaping Yuan, Weiping Jiang, Lili Ren, He Deng, Louis-S. Bouchard, Xin Zhou*, Maili Liu*. Hyperpolarized 129Xe Magnetic Resonance Imaging Sensor for H2S. Chemistry - A European Journal, Vol 23(32), 7648-7652. (2017).

[43]  Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S. Bouchard, Xin Zhou*. Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized 129Xe Magnetofluorescent Biosensor. Analytical Chemistry, Vol 89(4), 2288-2295. (2017).

[44]  Weiwei Ruan, Jianping Zhong, Ke Wang, Guangyao Wu, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Detection of the Mild Emphysema by Quantification of Lung Respiratory Airways with Hyperpolarized Xenon Diffusion MRI. Journal of Magnetic Resonance Imaging, Vol 45(3), 879-888. (2017).

[45]  He Deng, Wankai Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Mammogram Enhancement Using Intuitionistic Fuzzy Sets. IEEE Transactions on Biomedical Engineering, Vol 64(8), 1803-1814. (2017).

[46]  Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou*. Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized 129Xe Diffusion Kurtosis Imaging in Rat Models. Magnetic Resonance in Medicine, Vol 78(5), 1891-1899. (2017).

[47]  He Deng, Wankai Deng, Xianping Sun, Chaohui Ye, Xin Zhou*. Adaptive Intuitionistic Fuzzy Enhancement of Brain Tumor MR Images. Scientific Reports, Vol 6, 35760. (2016).

[48]  Zhiying Zhang, Yu Guan, Haidong Li, Xiuchao Zhao, Yeqing Han, Yi Xia, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou*. Quantitative Comparison of Lung Physiological Parameters in Single and Multiple Breathhold with Hyperpolarized Xenon Magnetic Resonance. Biomedical Physics & Engineering Express, Vol 2(5), 055013. (2016).

[49]  He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Entropy-Based Window Selection for Detecting Dim and Small Infrared Targets. Pattern Recognition, Vol 61(2017), 66-77. (2016).

[50]  Haidong Li, Zhiying Zhang, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Radiation-Induced Lung Injury with Hyperpolarized Xenon Magnetic Resonance. Magnetic Resonance in Medicine, Vol 76(2), 408-416. (2016).

[51]  Weiping Jiang, Iris Yuwen Zhou, Lingyi Wen, Xin Zhou*, Phillip Zhe Sun*. A Theoretical Analysis of Chemical Exchange Saturation Transfer Echo Planar Imaging (CEST-EPI) Steady State Solution and the CEST Sensitivity Efficiency-Based Optimization Approach. Contrast Media & Molecular Imaging, Vol 11(5), 415-423. (2016).

[52]  Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Fast Determination of Flip Angle and T1 in Hyperpolarized Gas MRI During a Single Breath-Hold. Scientific Reports, Vol 6, 25854. (2016).

[53]  He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Image Enhancement based on Intuitionistic Fuzzy Sets Theory. IET Image Processing, Vol 10(10), 701-709. (2016).

[54]  Shengjun Yang, Weiping Jiang, Lili Ren, Yaping Yuan, Bin Zhang, Qing Luo, Qianni Guo, Louis-S. Bouchard, Maili Liu, Xin Zhou*. Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction. Analytical Chemistry, Vol 88(11), 5835-5840. (2016).

[55]  He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Small Infrared Target Detection Based on Weighted Local Difference Measure. IEEE Transactions on Geoscience and Remote Sensing, Vol 54(7), 4204-4214. (2016).

[56]  Lili Ren, Shizhen Chen, Haidong Li, Zhiying Zhang, Jianping Zhong, Maili Liu, Xin Zhou*. MRI-Guided Liposomes for Targeted Tandem Chemotherapy and Therapeutic Response Prediction. Acta Biomaterialia, Vol 35, 260-268. (2016).

[57]  Qianni Guo, Qingbin Zeng, Weiping Jiang, Xiaoxiao Zhang, Qing Luo, Xu Zhang, Louis-S. Bouchard, Maili Liu, Xin Zhou*. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe. Chemistry - A European Journal, Vol 22, 3967-3970. (2016).

[58]  Haidong Li, Zhiying Zhang, Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Oxygen-Dependent Hyperpolarized 129Xe Brain MR. NMR in Biomedicine, Vol 29(3), 220-225. (2016).

[59]  He Deng, Jianping Zhong, Weiwei Ruan, Xian Chen, Xianping Sun, Chaohui Ye, Maili Liu, Xin Zhou*. Constant-Variable Flip Angles for Hyperpolarized Media MRI. Journal of Magnetic Resonance, Vol 263, 92–100. (2016).

[60]  He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Infrared Small Target Detection Using Multiscale-Gray-Difference Weighted Image Entropy. IEEE Transactions on Aerospace and Electronic Systems, Vol 52(1), 60-72. (2015).

[61]  Xiuchao Zhao, Xianping Sun, Maohua Zhu, Xiaofei Wang, Chaohui Ye, Xin Zhou*. Atomic Filter Based on Stimulated Raman Transition at the Rubidium D1 Line. Optics Express, Vol 23(14), 17988-17994. (2015).

[62]  Weiwei Ruan, Jianping Zhong, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI. Chinese Journal of Magnetic Resonance, Vol 32(2), 261-272. (2015).

[63]  Lili Ren, Shizhen Chen, Haidong Li, Zhiying Zhang, Chaohui Ye, Maili Liu, Xin Zhou*. MRI-Visible Liposome Nanovehicles for Potential Tumor-Targeted Delivery of Multimodal Therapies. Nanoscale, Vol 7, 12843-12850. (2015).

[64]  Xiaolei Zhu, Shizhen Chen, Qing Luo, Chaohui Ye, Maili Liu, Xin Zhou*. Body Temperature Sensitive Micelles for MRI Enhancement. Chemical Communications, Vol 51(44), 9085-9088. (2015).

[65]  Qi Wang, Shizhen Chen, Qing Luo, Maili Liu, Xin Zhou*. A Europium-Lipoprotein Nanocomposite for High-Sensitive MR-Fluorescence Multimodal Imaging. RSC Advances, Vol 5(3), 1808-1811. (2015).

[66]  Zheng Tan, Xianping Sun*, Jun Luo, Yong Cheng, Xiuchao Zhao, Xin Zhou, Jin Wang, Mingsheng Zhan*. Ultranarrow Bandwidth Tunable Atomic Filter via Quantum Interference-Induced Polarization Rotation in Rb Vapor. Chinese Optics Letters, Vol 12(12), 121404. (2014).

[67]  Ji Zhang, Weiping Jiang, Qing Luo, Xiaoxiao Zhang, Qianni Guo, Maili Liu, Xin Zhou*. Rational Design of Hyperpolarized Xenon NMR Molecular Sensor for the Selective and Sensitive Determination of Zinc Ions. Talanta, Vol 122, 101-105. (2014).

[68]  Qianni Guo, Qingbin Zeng, Xiaoxiao Zhang, Xin Zhou*. Highly Sensitive Detection of Mercury (II) in Aqueous Media by Tetraphenylporphyrin with a Metal Ion Receptor. Supramolecular Chemistry, Vol 26(10-12), 836-842. (2014).

[69]  Shizhen Chen, Yuqi Yang, Haidong Li, Xin Zhou*, Maili Liu. pH-Triggered Au-fluorescent Mesoporous Silica Nanoparticles for 19F MR/Fluorescent Multimodal Cancer Cellular Imaging. Chemical Communications, Vol 50(3), 283-285. (2014).

[70]  Guobin Liu, Xiaofeng Li, Xianping Sun, Jiwen Feng, Chaohui Ye, Xin Zhou*. Ultralow Field NMR Spectrometer with an Atomic Magnetometer Near Room Temperature. Journal of Magnetic Resonance, Vol 237, 158-163. (2013).

[71]  Mary Mazzanti, Ronn Walvick, Xin Zhou*, Yanping Sun, Niral Shah, Joey Mansour, Jessica Gereige, Mitchell Albert*. Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings. PLoS ONE, Vol 6(7), e21607.

[72]  Xin Zhou*, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, Marc Fisher, Mitchell Albert. MRI of Stroke Using Hyperpolarized 129Xe. NMR in Biomedicine, Vol 24(2), 170-175. (2011).

[73]   Xin Zhou, Dominic Graziani, Alexander Pines*. Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction. Proceedings of the National Academy of Sciences of the United States of America, Vol 106(40), 16903-16906. (2009).

[74]  Xin Zhou*, Xianping Sun, Jun Luo, Mingsheng Zhan, Maili Liu. Quantitative Estimation of SPINOE Enhancement in Solid State. Journal of Magnetic Resonance, Vol 196(2), 200-203. (2009).

[75]  Xin Zhou*, Mary Mazzanti, Jianbing James Chen, YangSheng Tzeng, Joey Mansour, Jessica Gereige, Arvind Venkatesh, Yanping Sun, Robert Mulkern, Mitchell Albert. Reinvestigating Hyperpolarized 129Xe Longitudinal Relaxation Time in the Rat Brain with Noise Considerations. NMR in Biomedicine, Vol 21(3), 217-225. (2008).

[76]  Xin Zhou*, Jun Luo, Xianping Sun, Xizhi Zeng, Shangwu Ding, Maili Liu, Mingsheng Zhan. Enhancement of Solidstate Proton NMR via SPINOE with Laser-Polarized Xenon. Physical Review B, Vol 70(5), 052405. (2004).

[77]  Xin Zhou*, Jun Luo, Xianping Sun, Xizhi Zeng, Mingsheng Zhan, Shangwu Ding, Maili Liu. Experiment and Dynamic Simulations of Radiation Damping of Laser-Polarized Liquid 129Xe at Low Magnetic Field in a Flow System. Applied Magnetic Resonance, Vol 26(3), 327-337. (2004).

[78]  Xin Zhou*, Xianping Sun, Jun Luo, Xizhi Zeng, Maili Liu, Mingsheng Zhan. Production of Hyerpolarized 129Xe Gas without Nitrogen by Optical Pumping at 133Cs D2 Line in Flow System. Chinese Physics Letters, Vol 21(8), 1501-1503. (2004).


科研活动

   
参与会议
(1)Hyperpolarized Xenon MRI Quantitatively Evaluates Lung Gas-exchange in Patients with COVID-19   约翰斯·霍普金斯大学磁共振研讨会   2020-10-29
(2)Multi-nuclear MRI for human and in vivo molecular imaging   2019年度人口健康领域研讨会   2019-06-25
(3)Lung Morphological and Functional MRI with Hyperpolarized 129Xe   第28届生物系统磁共振国际会议   2018-08-22
(4)Hyperpolarized Xe Lung MRI and Molecular Imaging   2018欧洲磁共振会议   2018-07-04
(5)Hyperpolarized 129Xe Lung MRI and Biosensors @ China   国际XeMAT 2018论坛   2018-05-07
(6)Functionalized Cryptophane-129Xe MRI Biosensor for Biothiols Detection through Thiol-addition Reaction   第24届国际医学磁共振会议   2016-05-09
(7)Quantitative Evaluation of Radiation-induced Lung Injury by Hyperpolarized Xenon MRI   超极化惰性气体 国际会议 (PING14)   2014-09-29
(8)Modified Cryptophane-A Cage for Multi-targeting 129Xe NMR   第55届实验磁共振会议   2014-03-23
(9)Hyperpolarized 129Xe Lung and Brain MRI   中德高场磁共振 成像联合研讨会 (CGHW)   2013-10-14
(10)Quantitative study chemical exchange of dilute sample by inversion transfer    第18届磁共振学会   2013-05-20
(11)Hyperpolarized Xenon Lung and Brain MRI   印度磁共振学会议   2013-02-05
(12)Ultrasensitive NMR and MRI   第四届海峡两岸磁共振会议   2012-10-25
(13)Hyperpolarized Noble Gas MRI: from Gas to Dissolved Phase   第四届亚太核磁共振研讨会   2011-10-18
(14)Hyperpolarized Xenon NMR and MRI Signal Amplification   第16 届全国波谱学学术会议   2010-11-25
(15)Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction (Hyper-SAGE)   第51届实验磁共振会议   2010-04-19
(16)Sensitivity Enhancement of Molecular Imaging with Remote Detection NMR   第13届北京分析测试学术报告会及展览会   2009-11-25
科研项目

1)国家自然科学基金委员会,创新研究群体项目,生命波谱与成像,2020-12024-12,在研,主持

2)国家科学技术部,变革性技术关键科学问题,肺癌的超高灵敏谱学与成像新技术研究,2019-92024-8,在研,主持

3)国家自然科学基金委员会,国家杰出青年科学基金,超灵敏磁共振成像,2017-12021-12,在研,主持

4)国家自然科学基金委员会,重大研究计划重点支持项目,外泌体介导的129Xe/19F双核MRI用于肺癌早期探测及其演进机制的研究,2019-12022-12,在研,主持

5)中国科学院,关键技术研发团队,超(高)灵敏磁共振波谱与成像技术研发团队,2020-12022-12,在研,主持

6)中国科学院,基础前沿科学研究计划 从0-1原始创新项目,肺的异构功能性数据获取与智能融合,2019-92029-8,在研,主持

7)国家自然科学基金委员会,国家重大科研仪器设备研制专项(部委推荐),用于人体肺部重大疾病研究的磁共振成像仪器系统研制,2013-12017-12,结题,主持

8)中国科学院,关键技术研发团队,超(高)灵敏磁共振波谱与成像技术,2017-52020-9,结题,主持

9湖北省,创新研究群体项目,活体肺部的超灵敏磁共振分子影像研究,2018-12020-12,结题,主持

10湖北省,技术创新专项重大项目,超灵敏磁共振活体肺部分子影像研究,2018-12019-12,结题,主持

11)中国科学院,科研装备研制项目,零场核磁共振波谱仪研制,2015-12016-12,结题,主持

12中国科学院,知识创新工程重要方向项目,重大疾病的高性能诊疗技术Cluster2011-12014-12,结题,主持

13国家自然科学基金委员会,青年项目,远程探测增强磁共振信号新方法,2011-012013-12,结题,主持

14)国家科学技术部,创新方法工作专项,肺部磁共振成像分析新方法研究,2010-92013-9,结题,主持

合作情况

Harvard University;
UC Berkeley;
Lawrence Berkeley National Lab;


指导学生

已指导学生

张继  硕士研究生  070302-分析化学  

朱筱磊  博士研究生  070302-分析化学  

王琦  硕士研究生  085238-生物工程  

任莉莉  博士研究生  070302-分析化学  

张智颖  博士研究生  070208-无线电物理  

曾庆斌  博士研究生  070302-分析化学  

阮伟伟  博士研究生  070208-无线电物理  

李海东  博士研究生  070208-无线电物理  

肖洒  博士研究生  070302-分析化学  

王崇武  硕士研究生  070302-分析化学  

李莎  博士研究生  070302-分析化学  

谢军帅  博士研究生  070208-无线电物理  

肖康达  博士研究生  070208-无线电物理  

现指导学生

张旭  博士研究生  070302-分析化学  

赵龙辉  博士研究生  070302-分析化学  

单海威  博士研究生  070302-分析化学  

刘小玲  博士研究生  070302-分析化学  

陈小明  硕士研究生  085208-电子与通信工程  

肖忠宇  硕士研究生  070302-分析化学  

乐曲儿  博士研究生  070302-分析化学  

岳森  硕士研究生  070302-分析化学  

隋美菊  博士研究生  070302-分析化学