生物核磁共振波谱学

招收硕士研究生、博士研究生

070302-分析化学

生物大分子核磁共振，结构生物学

2009-10--2010-10   澳大利亚国立大学   公派联合培养博士
2004-09--2011-12   华中师范大学   博士学位
2000-09--2004-06   河南师范大学   学士学位

2023-01至今，中国科学院精密测量科学与技术创新研究院, 研究员

2017-01~2022-12, 中国科学院精密测量科学与技术创新研究院, 副研究员

2014-06~2016-12,中国科学院武汉物理与数学研究所, 助理研究员，
2012-01~2014-06,在中国科学院武汉物理与数学研究所做博士后，合作导师李从刚研究员。

   

（1） 物数明星, 研究所（学校）, 2016
（2） 研究所2016年度突破奖, 研究所（学校）, 2016

   

[1] Chen Wang, Guohua Xu, Xiaoli Liu, Ling Jiang, Xin Zhou, Liu, Maili, Conggang Li. 19F Nuclear Magnetic Resonance Fingerprinting Technique for Identifying and Quantifying G‑Quadruplex Topology in Human Telomeric Overhangs. J Am Chem Soc[J]. 2024, [2] Xu, Guohua, Chen Wang, Hao Yu, Yapiao Li, Qiang Zhao, Xin Zhou, Conggang Li, Maili Liu. Structural basis for high-affinity recognition of aflatoxin B1 by a DNA aptamer.. Nucleic Acids Res.[J]. 2023, 41(14): 7666-7674, [3] Wu, Qiong, Liu, Xiaoli, Chai, Zhaofei, Cheng, Kai, Xu, Guohua, Jiang, Ling, Liu, Maili, Li, Conggang. Lanmodulin remains unfolded and fails to interact with lanthanide ions in Escherichia coli cells. CHEMICAL COMMUNICATIONS[J]. 2022, 58(59): 8230-8233, http://dx.doi.org/10.1039/d2cc02038f.
[4] Guohua Xu, Jiajing Zhao, Hao Yu, Chen Wang, Yangyu Huang, Qiang Zhao, Xin Zhou, Conggang Li, Maili Liu. Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(17): 7731-7740, https://pubs.acs.org/doi/10.1021/jacs.2c00478.
[5] Pei, Yunshan, Liu, Xiaoli, Cheng, Kai, Xu, Guohua, Jiang, Ling, Li, Conggang. Backbone resonance assignment of PDI b'xa' domain construct. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2021, 15(2): 409-413, http://dx.doi.org/10.1007/s12104-021-10038-3.
[6] Guo, Yuting, Yao, Chendie, Cheng, Kai, Wu, Qiong, Xu, Guohua, Jiang, Ling, Li, Conggang. NMR backbone resonance assignment of Japanese encephalitis virus capsid protein. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2021, 15(2): 403-407, http://dx.doi.org/10.1007/s12104-021-10037-4.
[7] Xu, Guohua, Zhao, Jiajing, Liu, Na, Yang, Minghui, Zhao, Qiang, Li, Conggang, Liu, Maili. Structure-guided post-SELEX optimization of an ochratoxin A aptamer. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(11): 5963-5972, http://dx.doi.org/10.1093/nar/gkz336.
[8] Zhu, Longyi, Zhou, Jun, Xu, Guohua, Li, Conggang, Ling, Pinghua, Liu, Bin, Ju, Huangxian, Lei, Jianping. DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission. CHEMICAL SCIENCE[J]. 2018, 9(9): 2559-2566, https://www.webofscience.com/wos/woscc/full-record/WOS:000431087700021.
[9] Wang, ShaoRu, Wang, JiaQi, Xu, GuoHua, Wei, Lai, Fu, BoShi, Wu, LingYu, Song, YanYan, Yang, XiRan, Li, Conggang, Liu, SiMin, Zhou, Xiang. The Cucurbit7Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition. ADVANCED SCIENCE[J]. 2018, 5(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000439842100010.
[10] Yao, Chendie, Wu, Qiong, Xu, Guohua, Li, Conggang. NMR backbone resonance assignment of New Delhi metallo-beta-lactamase. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2017, 11(2): 239-242, http://dx.doi.org/10.1007/s12104-017-9756-5.
[11] Tian, Tian, Song, Yanyan, Wei, Lai, Wang, Jiaqi, Fu, Boshi, He, Zhiyong, Yang, XiRan, Wu, Fan, Xu, Guohua, Liu, SiMin, Li, Conggang, Wang, Shaoru, Zhou, Xiang. Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions. NUCLEIC ACIDS RESEARCH[J]. 2017, 45(5): 2283-2293, https://www.webofscience.com/wos/woscc/full-record/WOS:000397286600014.
[12] Xu, Guohua, Zhao, Jiajing, Cheng, Kai, Wu, Qiong, Liu, Xiaoli, Liu, Maili, Li, Conggang. The Effects of Macromolecular Crowding on Calmodulin Structure and Function. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 23(28): 6736-6740, http://dx.doi.org/10.1002/chem.201700367.
[13] Guohua Xu, Kai Cheng, Qiong Wu, Prof. Dr. Maili Liu, Prof. Dr. Conggang Li. Confinement Alters the Structure and Function of Calmodulin. ANGEWANDTE CHEMIE INTERNATIONAL EDITION[J]. 2017, 56(2): 530-534, http://ir.wipm.ac.cn/handle/112942/10027.
[14] Li, Conggang, Zhao, Jiajing, Cheng, Kai, Ge, Yuwei, Wu, Qiong, Ye, Yansheng, Xu, Guohua, Zhang, Zeting, Zheng, Wenwen, Zhang, Xu, Zhou, Xin, Pielak, Gary, Liu, Maili, Cooks, RG, Pemberton, JE. Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells. ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 10[J]. 2017, 10: 157-182, https://www.webofscience.com/wos/woscc/full-record/WOS:000404991300008.
[15] Wang, ShaoRu, Min, YuanQin, Wang, JiaQi, Liu, ChaoXing, Fu, BoShi, Wu, Fan, Wu, LingYu, Qiao, ZhiXian, Song, YanYan, Xu, GuoHua, Wu, ZhiGuo, Huang, Gai, Peng, NanFang, Huang, Rong, Mao, WuXiang, Peng, Shuang, Chen, YuQi, Zhu, Ying, Tian, Tian, Zhang, XiaoLian, Zhou, Xiang. A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target. SCIENCE ADVANCES[J]. 2016, 2(4): http://dx.doi.org/10.1126/sciadv.1501535.
[16] Fu, Boshi, Huang, Jinguo, Chen, Yuqi, Wang, Yafen, Xue, Tianrui, Xu, GuoHua, Wang, Shaoru, Zhou, Xiang. Right-handed and left-handed G-quadruplexes have the same DNA sequence: distinct conformations induced by an organic small molecule and potassium. CHEMICAL COMMUNICATIONS[J]. 2016, 52(65): 10052-10055, http://ir.wipm.ac.cn/handle/112942/9501.
[17] Wang, ShaoRu, Zhang, QiuYan, Wang, JiaQi, Ge, XingYi, Song, YanYan, Wang, YaFen, Li, XiaoDan, Fu, BoShi, Xu, GuoHua, Shu, Bo, Gong, Peng, Zhang, Bo, Tian, Tian, Zhou, Xiang. Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene. CELL CHEMICAL BIOLOGY[J]. 2016, 23(9): 1113-1122, http://dx.doi.org/10.1016/j.chembiol.2016.07.019.
[18] Ye, Yansheng, Liu, Xiaoli, Xu, Guohua, Li, Conggang, Liu, Maili. Direct Observation of Ca2+-Induced Calmodulin Conformational Transitions in Intact Xenopus laevis Oocytes by 19F NMR Spectroscopy,. Angew. Chem. Int. ed[J]. 2015, [19] Ye, Yansheng, Liu, Xiaoli, Chen, Yanhua, Xu, Guohua, Wu, Qiong, Zhang, Zeting, Yao, Chendie, Liu, Maili, Li, Conggang. Labeling Strategy and Signal Broadening Mechanism of Protein NMR Spectroscopy in Xenopus laevis Oocytes. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 21(24): 8686-8690, http://dx.doi.org/10.1002/chem.201500279.
[20] Li Conggang. Ca(2+) modulating α-synuclein membrane transient interactions revealed by solution NMR spectroscopy. BBA-Biomem. 2014, [21] Xu, Guohua, Ye, Yansheng, Liu, Xiaoli, Cao, Shufen, Wu, Qiong, Cheng, Kai, Liu, Maili, Pielak, Gary J, Li, Conggang. Strategies for Protein NMR in Escherichia coli. BIOCHEMISTRY[J]. 2014, 53(12): 1971-1981, http://dx.doi.org/10.1021/bi500079u.
[22] Wu, Wenbo, Xu, Guohua, Li, Conggang, Yu, Gui, Liu, Yunqi, Ye, Cheng, Qin, Jingui, Li, Zhen. From Nitro- to Sulfonyl-Based Chromophores: Improvement of the Comprehensive Performance of Nonlinear Optical Dendrimers. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 19(21): 6874-6888, http://ir.wipm.ac.cn/handle/112942/1001.
[23] J Am Chem Socnull. 2004, 

   

（ 1 ） 线粒体中蛋白质原位核磁共振方法的建立, 负责人, 国家任务, 2016-01--2018-12
（ 2 ） 活细胞内G-四链体结构稳定性的测量方法及其在抗癌药物筛选中的应用研究, 负责人, 国家任务, 2019-01--2022-12
（ 3 ） 细胞中原子分辨的功能分子构象变化、相互作用和微环境效应的测定方法, 参与, 国家任务, 2020-01--2024-12
（ 4 ） 蛋白质激发态结构及与配体相互作用的核磁共振研究, 参与, 国家任务, 2019-08--2024-07