合成生物学; 酶工程; 微生物学；代谢工程

1.     Xin Pu, Caihong Weng, Yong Li, Biao Geng, Haiqian Yang, Xiaowei Peng, Yejun Han* Engineering mxotrophy in the chemolithoautotrophic Cupriavidus necator through hydrogenase induction. ACS Synthetic Biology. 2026,15(2), 773–788.

2.     Yong Li, Ling Zhao, Xin Pu, Biao Geng, Wei Liu, Jie Gao, Xiaowei Peng, Yejun Han*. Flavin-dependent monooxygenases as versatile biocatalysts in biomanufacturing: mechanisms, engineering, and applications. Biotechnology for Biofuels and Bioproducts,

2026.  https://doi.org/10.1186/s13068-026-02755-5.

3.     Haiqian Yang#, Wei Liu#, Jiwei Niu, Biao Geng, Pengfei Qiu, Hongshun Li, Junping Bao, Xin Pu, Yong Li, Xiaojing Jia, Yingxiang Sun*,Yejun Han* Integrated metagenomic–metabolomic insights into plant–microbe interactions mediated by Bacillus volatile compounds. Applied and Environmental Microbiology. 2026,92(4), https://doi.org/10.1128/aem.02523-25.

4.     Jianjun Ding#, Caihong Weng#, Ling Zhao#, Xiaowei Peng, Yejun Han*. A clean biorefinery process for converting corn stover into hydrogen, electricity, and aromatic flavor compounds. Renewable Energy. 2026: https://doi.org/10.1016/j.renene.2025.124006.

5.     Caihong Weng, Xin Pu, Ruohao Tang, Yejun Han*. Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator. SCIENCE CHINA Life Sciences. 2025. https://doi.org/10.1007/s11427-024-2864-5.

6.     Haiqian Yang, Yejun Han,Xiaowei Peng*. Efficient production of sophorose from glucose and its potentially industrial application in cellulase production. Bioresource Technology. 2024, 412,  DOI: 10.1016/j.biortech.2024.131402.

7.     Haiqian Yang, Jie Gao, Xiaowei Peng, Yejun Han*. Application of synthetic biology strategies to promote biosynthesis of fatty acids and their derivatives. Advances in Applied Microbiology.2024(128),83-104. https://doi.org/10.1016/bs.aambs.2024.05.002.

8.     Caihong Weng, Ruohao Tang, Xiaowei Peng, Yejun Han*. Co-conversion of lignocellulose-derived glucose, xylose, and aromatics to polyhydroxybutyrate by metabolically engineered Cupriavidus necator. Bioresource Technology,2023, 10.1016/j.biortech.2023.128762

9.     Caihong Weng, Xiaowei Peng, Yejun Han*. From methane to value-added bioproducts: microbial metabolism, enzymes, and metabolic engineering. Advances in Applied Microbiology. 2023, 124, 119-146.https://doi.org/10.1016/bs.aambs.2023.07.004.

10.   Ruohao Tang^#, Xiaowei Peng^#, Caihong Weng, Yejun Han*. The over-expression of phasin and regulator genes promoting the synthesis of polyhydroxybutyrate in Cupriavidus necator H16 under non-stress conditions. Applied and Environmental Microbiology. 2022, 88(2), https://doi.org/10.1128/AEM.01458-21. (^#co-first author)

11.  Haiqian Yang, Xiaojing Jia, Yejun Han*. Microbial redox coenzyme engineering and applications in biosynthesis. Trends in Microbiology. 2022, 30(4), https://doi.org/10.1016/j.tim.2022.01.012.

12.   Caihong Weng, Xiaowei Peng, Yejun Han*. Depolymerization and conversion of lignin to value-added bioproducts by microbial and enzymatic catalysis. Biotechnology for Biofuels and Bioproducts. 2021. 14:84, https://doi.org/10.1186/s13068-021-01934-w.

13.  Ruohao Tang, Caihong Weng, Xiaowei Peng*, Yejun Han*. Metabolic engineering of Cupriavidus necator H16 for improved chemoautotrophic growth and PHB production under oxygen-limiting conditions. Metabolic Engineering. 2020.61:11-23.

14.   Xiaojing Jia, Yejun Han*. The extracellular endo-β-1,4-xylanase with multidomain from the extreme thermophile Caldicellulosiruptor lactoaceticus is specific for insoluble xylan degradation. Biotechnology for Biofuels and Bioproducts. 2019.  10.1186/s13068-019-1480-1.

15.   Xiaojing Jia, Robert Kelly, Yejun Han*. Simultaneous biosynthesis of (R)-acetoin and ethylene glycol from D-xylose through in vitro metabolic engineering. Metabolic Engineering Communications. 2018. https://doi.org/10.1016/j.mec.2018.e00074

16.Xiaowei Peng, Robert M. Kelly, and Yejun Han*. Sequential processing with fermentative Caldicellulosiruptor kronotskyensis and chemolithoautotrophic Cupriavidus necator for converting rice straw and CO₂ to polyhydroxybutyrate. Biotechnology and

Bioengineering. 2018.10.1002/bit.26578

17.   Xiaowei Peng, Chao Li*, Jing Liu, Zili Yi, Yejun Han^*. Changes in composition, cellulose degradability and biochemical methane potential of Miscanthus species during the growing season. Bioresource Technology. 2017 (235): 389–395.

18.   Xiaojing Jia, Xiaowei Peng, Ying Liu, Yejun Han*. Conversion of cellulose and hemicellulose of biomass simultaneously to acetoin by thermophilic simultaneous saccharification and fermentation. Biotechnology for Biofuels and Bioproducts. 2017.

https://doi.org/10.1186/s13068-017-0924-8.

19.   Xiaowei Peng,Hong Su,Shuofu Mi,Yejun Han*.A multifunctional thermophilic glycoside hydrolase from Caldicellulosiruptor owensensis with potential applications in production of biofuels and biochemicals. Biotechnology for Biofuels and Bioproducts. 2016. doi:

10.1186/s13068-016-0509-y.

20.   Andrew J. Loder^#, Yejun Han^#, Aaron B. Hawkins^#, Hong Lian, Gina L. Lipscomb, Gerrit J. Schut, Matthew W. Keller, Michael W.W. Adams, Robert M. Kelly*. Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO₂ fixation cycle in

extremely thermoacidophilic archaea. Metabolic Engineering. 2016. http://dx.doi.org/10.1016/j.ymben.2016.10.009. (^#co-first author)

21.   Xiaowei Peng, Weibo Qiao, Shuofu Mi, Xiaojing Jia, Hong Su, Yejun Han*. Characterization of hemicellulase and cellulase from the extremely thermophilic bacterium Caldicellulosiruptor owensensis and their potential application for bioconversion of

lignocellulosic biomass without pretreatment. Biotechnology for Biofuels and Bioproducts. 2015. doi: 10.1186/s13068-015-0313-0.

22.   YejunHan^#, Vinayak Agarwal^#, Dylan Dodd^#, Jason Kim, Brian Bae, Roderick I. Mackie, Satish K. Nair, and Isaac K.O. Cann*. Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. The Journal of Biological Chemistry. 2012. 287(42): 34946-34960 (^# co-first author).

23.  Yejun Han, Aaron S. Hawkins, Michael W.W. Adams and Robert M. Kelly*. Epimerase (Msed_0639) and Mutase (Msed_0638, Msed_2055) Convert (S)-methylmalonyl-CoA to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle. Applied and Environmental Microbiology. 2012. 78(17): 6194-6202.

24.   Yejun Han, Dylan Dodd, Charles W. Hespen, Samuel Ohene-Adjei, Charles M. Schroeder, Roderick I. Mackie, and Isaac K.O. Cann*. Comparative analyses of two thermophilic enzymes exhibiting both β-1,4 mannosidic and β-1,4 glucosidic cleavage activities from Caldanaerobius polysaccharolyticus. Journal of Bacteriology. 2010. 192(16): 4111-4121.

25.   Carl J. Yeoman, Yejun Han, Dylan Dodd, Charles M. Schroeder, Roderick I. Mackie, and Isaac K.O. Cann*. Thermostable enzymes as biocatalysts in the biofuel industry. Advances in Applied Microbiology. 2010. 70: 1-55.