The newly rising synthetic biology is expected to solve some of the global challenges, such as converting cheap, renewable resources into biofuels or chemicals; producing high quality drugs to fight disease. The overall research goal in our group is to develop usable knowledge and characterize bio-parts (new genes or enzymes), which will advance synthetic biological strategies for improvement of the activity and composition of lignocellulolytic enzyme complex as well as the biosynthesis of rare natural products with potential therapeutic applications, and finally lead to technologies deployable in industry.

Ph. D. Molecular Ecology, The University of Tokyo, Japan (1997.4—2000.3);

M.S. Forest Ecology, Central-South Forestry University, China (1990.9-1993.6);

B.A. Forestry, Central-South Forestry University, China (1984.9-1988.6);

2004 - present:  Principal investigator, Institute of Plant Physiology and Ecology , 

Shanghai Institutes for Biological Science, CAS;

2003 - 2004:  Associate Professor, Shanghai Jiaotong University, China;

2000 - 2003:  Post-doc fellow at the University of Tokyo, Japan, sponsored by JSPS

(Japanese Society for Promotion of Sciences);

1993 - 1997:  Lecturer, Laboratory of Ecology, Department of Forestry

                      Central-South Forestry University, China;

1988 - 1990:  Assistant Professor, Department of Forestry,

                   Hunan Forestry Technique College, China;

   

1.       Yang CS, Wang Y, Su Z…….Yang X, Ma DW, Zhao GP, Zhou ZH. Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol. Nature communications 2024,

2.       Xiao M, Wang YM……,Gen Zou*, Zhihua Zhou*, Pingping Wang*. Repurposing the cellulase workhorse Trichoderma reesei as a ROBUST chassis for efficient terpene production. Green Chemistry 2023, DOI: 10.1039/D3GC01770B;

3.       Li C#, Yan X#, Xu Z#, Wang Y, Shen X, Zhang L, Zhou Z*, Wang P*. Pathway elucidation of   bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae. Communications biology 2022, 5: 775

4.       Shunxing Chai, Zhihua Zhu, Ernuo Tian, Meili Xiao, Yan Wang, Gen Zou*&Zhi-hua Zhou1*. Building a Versatile Protein Production Platform Using Engineered Trichoderma reesei. ACS Synthetic Biology 2022, 11(1) : 486-496

5.       Xiaodong Li, Yinmei Wang, Zhenjun Fan, Yan Wang, Pingping Wang*, Xing Yan*, Zhihua Zhou*. High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae. Metabolic Engineering 2021, 66: 87-97;

6.       Pingping Wang#, Chaojing Li#, Xiaodong Li#, Wenjun Huang#, Yan Wang, Jiali Wang, Yanjun Zhang, Xiaoman Yang, Xing Yan*, Ying Wang* and Zhihua Zhou*. Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli. Science Bulletin 2021 doi: 10.1016/j.scib.2021.03.002

7.       Gen Zou#,  Meili Xiao#,  Shunxing Chai,  Zhihua Zhu,  Ying Wang and Zhihua Zhou*. Efficient genome editing in filamentous fungi via an improved CRISPR-Cas9 ribonucleoprotein method facilitated by chemical reagents. Microb Biotechnol 2020 doi: 10.1111/1751-7915.13652

8.       Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan*, Zhihua Zhou*. Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Cell Discovery 2019, 5 (5): 1-14

9.       Wei W, Wang P, Wei Y, Liu Q, Yang C, G Zhao, Yue J *, Yan X *, Zhou Z * Characterizations of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts. Molecular Plant 2015, 8(9): 1412-1424 

10.     Rui Liu, Ling Chen, Yanping Jiang, Zhihua Zhou*, Gen Zou*. Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system. Cell Discovery 2015, 1, 15007; doi:10.1038/celldisc.2015.7

11.     Wang P., Y Wei, Y Fan, Q Liu, W Wei, C Yang, L Zhang, G Zhao, J Yue*, X Yan*, Z Zhou*. Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts. Metab Eng 2015, 29: 97-105. 27

12.    Yan X, Y Fan, W Wei, P Wang, Q Liu, L Zhang, G Zhao*, J Yue*, Z Zhou*. Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Research 2014, 24:770–773

已指导学生

刘芳华  博士研究生  071005-微生物学  

李欣峰  博士研究生  071005-微生物学  

于瑞嵩  博士研究生  071005-微生物学  

张珺  博士研究生  071005-微生物学  

刘通  博士研究生  071005-微生物学  

汪若凡  博士研究生  071005-微生物学  

马良  博士研究生  071005-微生物学  

魏勇军  博士研究生  071005-微生物学  

钱昌丽  博士研究生  071005-微生物学  

陈玲  博士研究生  071005-微生物学  

江艳萍  博士研究生  071005-微生物学  

魏维  博士研究生  071005-微生物学  

刘睿  博士研究生  071005-微生物学  

王平平  博士研究生  071005-微生物学  

杨成帅  博士研究生  071005-微生物学  

柴顺星  博士研究生  071005-微生物学  

邢宏观  博士研究生  071005-微生物学  

李晓东  博士研究生  071005-微生物学  

朱志华  博士研究生  071005-微生物学  

李超静  博士研究生  071005-微生物学  

熊伦艺  硕士研究生  085238-生物工程  

现指导学生

田尔诺  博士研究生  071005-微生物学  

樊震鋆  博士研究生  071005-微生物学  

魏文苹  博士研究生  071005-微生物学  

肖美丽  博士研究生  071005-微生物学  

马迩东  硕士研究生  071005-微生物学  

王引梅  博士研究生  071005-微生物学  

张通  博士研究生  071005-微生物学  

苏振  硕士研究生  086000-生物与医药  

张娜  博士研究生  071005-微生物学  

刘占圣  硕士研究生  086000-生物与医药