Bioactive (Antibacterial, Cytotoxic, Antivirus) Marine Natural Products from Deep-sea Bacteria and Their Biosynthetic Pathway Studies.  

2013 Recieved Ph.D. degree from joint program of UCAS and HKUST

2013.06-Now        Institute of Deep-sea Science and Engineering, CAS.

2019.09-2020.11   Boston University, Visiting Scholar.

2013.12-2014.12   Hong Kong University of Science and Technology, Visiting Scholar.

1. Liu YY, Chen HX, Chen GY, Nong XH*, Han Z*. Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus Aspergillus candidus HNNU0546. Journal of Natural Products. 2025 Dec 8.
2. LJ Yang, Z Han, YC Gu, CL Shao, CY Wang. New Sulfurated Butyrolactones from the Fungus Penicillium janthinellum. Chemistry & Biodiversity, 2025, e202401966
3. LJ Yang, L Lv, Z Han, YC Gu, X Li, CL Shao, ZQ Liu, CY Wang Penijanacoranes A-F, Acorane‐Type Sesquiterpenes from a Deep Sea‐Derived Fungus Penicillium janthinellum SH0301. Chinese Journal of Chemistry, 2025, 43 (3), 268-274
4. S Bai, K Shang, S Zeng, Z Huang, Z Han*. Genome analysis of Salinimicrobium sp. 3283s, a deep-sea bacterium isolated from the sediments of South China Sea, China. Marine Genomics, 2024, 76, 101125
5. B Zhu, Z Cen, Y Chen, K Shang, J Zhai, M Han, J Wang, Z Chen, T Wei, Z Han*. α-Pyrone mediates quorum sensing through the conservon system in Nocardiopsis sp. Microbiological Research 285, 127767
6. JW Wang, K Shang, SY Wu, BY Zhu, MG Han, Y Zhao, YQ Chen, J Xie, B Huang, Z Han*. Complete genome sequence of piezotolerant Stutzerimonas kunmingensis 7850S isolated from the sediment of the Mariana Trench. Marine Genomics, 2022. 66, 100996
7. X Zhang, K Wu, Z Han, Z Chen, Z Liu, Z Sun, L Shao, Z Zhao, L Zhou. Microbial diversity and biogeochemical cycling potential in deep-sea sediments associated with seamount, trench, and cold seep ecosystems. Frontiers in Microbiology, 2022, 13, 1029564
8. H Jing, X Xiao, Y Zhang, Z Li, H Jian, Y Luo, Z Han. Composition and ecological roles of the core microbiome along the abyssal-hadal transition zone sediments of the Mariana Trench. Microbiology Spectrum, 2022, 10 (3), e01988-21
9. Sun, Y., Sun, J., Yang, Y., Lan, Y., Ip, J. C. H., Wong, W. C., Han Z., Jian-Wen Qiu & Qian, P. Y. (2021). Genomic signatures supporting the symbiosis and formation of chitinous tube in the deep-sea tubeworm Paraescarpia echinospica. Molecular biology and evolution, 38(10), 4116-4134.
10. Ip, J. C. H., Xu, T., Sun, J., Li, R., Chen, C., Lan, Y., Han Z. ……,& Qiu, J. W. (2021). Host–endosymbiont genome integration in a deep-sea chemosymbiotic clam. Molecular Biology and Evolution, 38(2), 502-518.
11. Kong, W.; Zhao, C.; Gao, X.; Wang, L.; Tian, Q.; Liu, Y.; Xue, S.; Han, Z.; Chen, F.; Wang, S. Characterization and Transcriptome Analysis of a Long-Chain n-Alkane-Degrading Strain Acinetobacter pittii SW-1. Int. J. Environ. Res. Public Health 2021, 18, 6365. https://doi.org/10.3390/ijerph18126365
12. Yang L-J, Peng X-Y, Zhang Y-H, Liu Z-Q, Li X, Gu Y-C, Shao C-L, Han Z*, Wang C-Y*. Antimicrobial and Antioxidant Polyketides from a Deep-Sea-Derived Fungus Aspergillus versicolor SH0105. Marine Drugs. 2020; 18(12):636.
13. Li, W. L., Huang, J. M., Zhang, P. W., Cui, G. J., Wei, Z. F., Wu, Y. Z., Gao Z. M., Han Z., Wang, Y. (2019). Periodic and spatial spreading of alkanes and Alcanivorax bacteria in deep waters of the Mariana Trench. Applied and environmental microbiology, 85(3), e02089-18.
14. Wang S-l, Li Y-l, Han Z, Chen X, Chen Q-j, Wang Y, He L-s. Molecular Characterization of a Novel N-Acetylneuraminate Lyase from a Deep-Sea Symbiotic Mycoplasma. Marine Drugs. 2018; 16(3):80. 
15. Han Z, Li YX, Liu LL, Lu L, Guo XR, Zhang XX, Zhang XY, Qi SH, Xu Y, Qian PY* (2017). Thielavins W-Z₇, New antifouling thielavins from the marine-derived fungus Thielavia sp. UST030930-004. Marine Drugs, 15(5), 128.
16. Han Z, Sun J, Zhang Y, He F, Xu Y, Matsumura K, He LS, Qiu JW, Qi SH, Qian PY*. (2013). iTRAQ-based proteomic profiling of the barnacle Balanus amphitrite in response to the antifouling compound meleagrin, Journal of Proteome Research. 12 (5), 2090–2100.
17. Han Z, Xu Y, McConnell O, Liu L, Li Y, Qi S, Huang X, Qian PY*. (2012). Two antimycin A analogues from marine-derived Streptomyces lusitanus. Marine Drugs, 10 (3), 668-676.
18. Han Z, Mei WL, Zhao YX, Deng YY. Dai HF*. (2009). A new cytotoxic isocoumarin isolated from endophytic fungus Penicillium sp. 091402 of mangrove plant Bruguiera sexangula. Chemistry of Natural Compounds, 45 (6): 805-807.
19. Han Z, Mei WL et al. Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove plant Cerbera manghas. Chemical Journal of Chinese University (In Chinese) 2008, 29 (4): 749-752.
20. Han Z, Mei WL et al. Studies on the chemical constituents from the endophytic fungus Penicillium sp. 091402 of mangrove plant Bruguiera sexangula. Chinese Journal of Marine Drugs (In Chinese). 2008, 27(4): 9-13.
21. He F, Han Z, Peng J, Qi SH*. (2013). Antifouling indole alkaloids from two marine derived fungi. Natural Product Communications, 8, 329-332.
22. Sun JF, Han Z, Zhou XF. Yang B, Lin XP. Liu J. Peng Y. Yang XW. Liu YH*. (2013). Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea. Tetrahedron, 69(2), 871–880.
23. Mei WL, Han Z, Cui HB, Zhao YX, Deng YY, Dai HF*. (2010). A New Cytotoxic Iridoid from Callicarpa nudiflora. Natural Product Research, 24 (10):899-904.
24. Lei H, Sun JF, Han Z, Zhou XF, Yang B, Liu YH*. (2014). Fragilisinins A-L, New Briarane-type Diterpenoids from Gorgonian Junceella fragilis. RSC Advances, 4(10), 5261-5271.
25. Liu LL, Xu Y, Han Z, Li YX, Lu L, Lai PY, Zhong JL, Guo XR, Zhang XX, Qian PY*. (2012). Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs, 10(11), 2571-2583.
26. Dai HF, Liu J, Han Z, Zeng YB, Wang H, Mei WL. (2010). Two new 2-(2-phenylethyl)chromones from Chinese eaglewood. Journal of Asian Natural Products Research, 12(2), 134-137.
27. Zhang X, Wu J, Han Z, Mei WL. Dai HF. (2010). Antioxidant and Cytotoxic Phenolic Compounds of Areca Nut, Chemical Research in Chinese Universities, 26(1), 161-164.
28. Dai WJ1, Wu J, Han Z, Mei WL, Dai HF. (2009). Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis. Journal of Asian Natural Products Research, 11 (8):704 – 709.
29. Liu LL, He LS, Xu Y, Han Z, Li YX, Zhong JL, Guo XR, Zhang XX, Ko KM, Qian PY. (2013) Caspase-3-dependent apoptosis of citreamicin ε-induced HeLa cells is associated with ROS generation. Chemical Research in Toxicology, 26(7), 1055-1063.
30. Bao J, Sun YL, Zhang XY, Han Z, Gao HC, He F, Qian PY, Qi SH. (2013). Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. The Journal of antibiotics, 66(4): 219-23.
31. Li YX, Xu Y, Liu L, Han Z, Lai PY, Guo X, Zhang X, Lin W, Qian PY. (2012). Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Marine Drugs, 10, 319-328.
32. Chen L, Zhang H, Sun J, Wong YH, Han Z, Au DW, Bajic VB, Qian PY. (2014). Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Aquatic Toxicology. 157. 47-56.
33. Li Y, Zhang F, Xu Y, Matsumura K, Han Z, Liu L, Lin W, Jia Y, Qian PY. (2012). Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds. Biofouling, 28(8), 857–864.  
34. Huang XZ, Xu Y, Zhang YF, Zhang Y, Wong YH, Han Z, Yin Y, Qian PY. (2014) Nontoxic piperamides and their synthetic analogues as novel antifouling reagents. Biofouling, 30(4), 473-481.
35. Wang KL, Xu Y, Lu L, Li Y, Han Z, Zhang J, ... & Qian PY (2015). Low-toxicity diindol-3-ylmethanes as potent antifouling compounds. Marine Biotechnology, 17(5), 624-632.
36. Wang KL, Zhang G, Sun J, Xu Y, Han Z, Liu L L, ... & Qian PY (2016). Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway. Biofouling, 32(1), 35-44.

Marine Natural Products from Deep-sea Bacteria and Their Biosynthetic Pathway Studies.

Hong Kong University of Science and Technology

Boston University

已指导学生

朱柏羽  硕士研究生  070703-海洋生物学  

翟吉安  硕士研究生  085238-生物工程  

韩梅桂  硕士研究生  070703-海洋生物学  

岑梓韵  硕士研究生  070703-海洋生物学  

现指导学生

陈蓉  硕士研究生  070703-海洋生物学  

吴泽昊  硕士研究生  070703-海洋生物学  

朱慧  硕士研究生  070703-海洋生物学  

 Membership of Youth Innovation Promotion Association of Chinese Academy of Sciences （2015）

 Year 2013 The Scholarship of Dean, Chinese Academy of Sciences (2013)

 Year 2009 Outstanding student of Chinese Academy of Sciences (2010)