Roles of higher-order chromatin structure in cell fate determination

Histone modifications and RNA-binding proteins in somatic cell reprogramming

Improvement of the efficiency and quality of induced pluripotent stem cells and neural stem cells and the application

2005. Ph.D. Institute of Botany, Chinese Academy of Sciences. China. 

2002. M.S.  Shanxi Agricultural University. China.

​1999. Shanxi Agricultural University. China.

2011.10-Present. Principal Investigator/Professor. Hundred Talent Scholar of CAS, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences. Guangzhou, China. 

2015.08-present. Joint Principal Investigator, Center for Excellence in Molecular Cell Science, the Chinese Academy of Sciences. Guangzhou, China. 

2008.11- 2011.10. Research fellow. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Mentor: Dr. Gary Felsenfeld (US academician). 

2006.11- 2008.11. Postdoctoral Fellow. The Pennsylvania State University, Department of Biochemistry and Molecular Biology, State College, PA, USA. 

2005.11- 2006.11. Visiting Fellow. National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD, USA.

1) Ping W, Hu J, Hu G, Li H, Song Y, Xia Q, Yao M, Gong S, Jiang C, Yao H*. 2017. Genome-wide DNA Methylation Analysis Reveals that Mouse Chemical iPSCs Have Closer Epigenetic Features to mESCs than OSKM-integrated-iPSCs. Cell Death & Disease (In press).

2) Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H*. 2017. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-based Repression of RYBP and its PRC1-dependent and -independent Functions. Cell Stem Cell 20: 462-477. (http://dx.doi.org/10.1016/j.stem.2016.12.002).

3) Li W, Shang L, Huang K, Li J, Wang Z, Yao H*. 2017. Identification of Critical Base Pairs Required for CTCF Binding in Motif M1 and M2. Protein & Cell 8: 544-549. 

4) Huang K, Zhang X, Shi J, Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B, Chen J, Pan G, Jiang C, Pei D*, Yao H*. 2015. Dynamically Reorganized Chromatin is the Key for the Reprogramming of Somatic Cells to Pluripotent Cells. Scientific Reports 5:17691.

5) Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G, Yao H*. 2013. Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding factor (CTCF) is Negatively Regulated by the Condensin Complex. Journal of Biological Chemistry 288: 26067-26077.

6) Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero R, Felsenfeld G. 2010. Mediation of CTCF Transcriptional Insulation by DEAD-box RNA-binding Protein p68 and Steroid Receptor RNA Activator SRA. Genes & Development 24: 2543-2555.

7) Hu J^＃, Yao H^＃, Gan F, Tokarski A, Wang Y. 2012. Interaction of OKL38 and p53 in Regulating Mitochondrial Structure and Function. PLoS One 7: e43362. (^＃Equal contribution).

8) Yao H, Li P, Venters B, Zheng S, Thompson P, Pugh BF, Wang Y. 2008. Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis. Journal of Biological Chemistry 283: 20060-20068.

9) Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H, Wang H. 2017. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Research 45: 8785-8805.

10) Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D. 2015. The Oncogene c-Jun Impedes Somatic Cell Reprogramming. Nature Cell Biology 17:856-67.

11) Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. 2014. Transcriptional Pause Release is a Rate-limiting Step for Somatic Cell Reprogramming. Cell Stem Cell 15: 574-588.

12) Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao S, Mo K, Li Y, Lai K, Qi J, Yao H, Pan G, Xu GL, Pei D. 2013. Vitamin C Modulates TET1 Function during Somatic Cell Reprogramming. Nature Genetics 45:1504-1509.

13) Pan G, Wang T, Yao H, Pei D. 2012. Somatic Cell Reprogramming for Regenerative Medicine: SCNT vs. iPS Cells. Bioessays 34: 472-476.

14) Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G. 2012. Chromatin Domains, Insulators, and the Regulation of Gene Expression. Biochim Biophys Acta 1819: 644-651.

15) Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y. 2010. Coordination of PAD4 and HDAC2 in the Regulation of p53-target Gene Expression. Oncogene 29: 3153-3162.

16) Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson P, Gilmour D, Wang Y. 2008. Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4. Molecular and Cellular Biology 28: 4745-4758.

17) Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K. 2008. The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase. Journal of Biological Chemistry 283: 9040-9048.

18) Tian S, Yao H, Deng X, Xu X, Qin G, Chan Z. 2007. Characterization and Expression of beta-1, 3-Glucanase Genes in Jujube Fruit Induced by the Microbial Biocontrol Agent Cryptococcus laurentii. Phytopathology 97: 260-268.

19) Yao H, Tian S. 2005. Effects of a Biocontrol Agent and Methyl Jasmonate on Postharvest Diseases of Peach Fruit and the Possible Mechanisms Involved. Journal of Applied Microbiology 98: 941-950.

20) Yao H, Tian S. 2005. Effects of Pre- and Postharvest Application of Salicylic Acid or Methyl Jasmonate on Inducing Disease Resistance of Sweet Cherry Fruit in Storage. Postharvest Biology and Technology 35: 253-262.

21) Yao H, Tian S. Wang Y. 2004. Sodium Bicarbonate Enhances Biocontrol Efficacy of Yeasts on Fungal Spoilage of Pears. International Journal of Food Microbiology 93: 297-304.

1. National Academic Conference of Chinese society of cell biology in 2017, Xiamen, Fujian, China. September 26-29, 2017. (Invited speaker)

2.  The seventh annual meeting of Chinese Stem Cells, Yinchuan, Ningxia, China. July 6-10, 2017. (Invited Speaker)

3.  ISSCR 2017 annual meeting. Boston, USA. June 14-17, 2017. (Invited Speaker)

4. The First Chromatin Biology Conference of Chinese Society of Cell Biology, Shenzhen, China. April 14-16, 2017. (Invited speaker)

5.  The 9th Guangzhou International Conference on Stem Cell and Regenerative Medicine, Guangzhou, December 20-21, 2016.

6. Epigenetics, Chromatin & Transcription. Cold Spring Harbor Asia Conferences. Suzhou, China. May 9-13, 2016. 

7. Spliceosome Kinetics Catalysis, and Regulation, Tsinghua University, Beijing, China. April 21-22, 2016.

8. The 8th Guangzhou International Conference on Stem Cell and Regenerative Medicine, Guangzhou, China. December 18-19, 2015.

9. Hangzhou Epigenetic Retreat. Hangzhou, China. October 16-18, 2015. (Invited Speaker)

10. 2015 National Academic Conference of National Society for cell biology, Shenzhen, April 1-4, 2015. (Invited Speaker)

已指导学生

黄开猛  博士研究生  071009-细胞生物学  

胡功成  博士研究生  071009-细胞生物学  

李欢欢  博士研究生  071009-细胞生物学  

李娇  博士研究生  071009-细胞生物学  

龚士欣  博士研究生  071009-细胞生物学  

夏晴  博士研究生  071009-细胞生物学  

董晓涛  博士研究生  071009-细胞生物学  

王丽莎  硕士研究生  071009-细胞生物学  

郭蓉  博士研究生  071009-细胞生物学  

李尧益  博士研究生  071009-细胞生物学  

颜成鸿  硕士研究生  085238-生物工程  

现指导学生

平王芳  博士研究生  071009-细胞生物学  

温毓麟  博士研究生  071009-细胞生物学  

王珏涵  博士研究生  071009-细胞生物学  

章杰  博士研究生  071009-细胞生物学  

李清  博士研究生  071009-细胞生物学  

王新秀  博士研究生  071009-细胞生物学  

王钰翔  硕士研究生  071009-细胞生物学  

卢玉丽  博士研究生  071009-细胞生物学  

刘妍江  博士研究生  071009-细胞生物学  

黄赛南  博士研究生  071009-细胞生物学  

钟宏新  硕士研究生  071010-生物化学与分子生物学  

1. Excellent Final evaluation of Hundred-talent Program Winner in the Chinese Academy of Sciences, 2017.

2. Outstanding Young Scientist Award, Guangzhou branch in the Chinese academy of Sciences, 2016. 

3. Hundred-talent Program Winner in the Chinese Academy of Sciences, 2012.

4. Fellow Award for Research Excellent at National Institutes of Health, 2010.

5. The Presidential Award in the Chinese Academy of Sciences, 2004.