Micro/Nano- particle based vaccine adjuvant and tumor therapy

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2008.9~2012.7 Doctoral Course

National Key Laboratory of Biochemical Engineering, IPE, CAS, Beijing, China
Specialty: Biochemistry

2005.9~2008.7　 Master Course
State Key Laboratory of Microbial Technology, Shandong University, Jinan, China
Specialty: Microbiology

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2021.1- now          Young Professor    State Key Laboratory of Biochemical Engineering, IPE, CAS, Beijing, China

2015.7-2020.12  Associate Professor    State Key Laboratory of Biochemical Engineering, IPE, CAS, Beijing, China

2012.7-2015.7      Assistant Professor  State Key Laboratory of Biochemical Engineering, IPE, CAS, Beijing, China

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SCI Publications (First author/Co-First author)

[1] Prophylactic vaccine delivery systems against epidemic infectious diseases, Adv Drug Deliv Rev, (2021) 113867.

[2] Transport of a graphene nanosheet sandwiched inside cell membranes, Sci Adv, 5 (2019) eaaw3192.

[3] Packaging and delivering enzymes by amorphous metal-organic frameworks, Nat Commun, 10 (2019) 5165.

[4] The role of the lateral dimension of graphene oxide in the regulation of cellular responses, Biomaterials, 33 (2012) 4013-4021.

[5] Exploration of graphene oxide as an intelligent platform for cancer vaccines, Nanoscale, 7 (2015) 19949-19957.

[6] Macrophage responses to the physical burden of cell-sized particles, J Mater Chem B, 6 (2018) 393-400.

[7] Cytosolic delivery of HBsAg and enhanced cellular immunity by pH-responsive liposome, Journal of Controlled Release, 324 (2020) 460-470.

[8] Particle size affects the cellular response in macrophages, Eur. J. Pharm. Sci., 41 (2010) 650-657.

[9] The orchestration of cellular and humoral responses is facilitated by divergent intracellular antigen trafficking in nanoparticle-based therapeutic vaccine, Pharmacol. Res., 65 (2012) 189-197.

[10] Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications, Vaccine, 33 (2015) 5927-5936.

[11] The interacting role of physical stiffness and tumor cells on the macrophages polarization, Colloid Surf. A-Physicochem. Eng. Asp., 552 (2018) 81-88.

[12] Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect, Acta Chim. Sinica, 79 (2021) 1244-1256.

[13] Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines, Acta Polymerica Sinica, 51 (2020) 125-135.

SCI Publications (Others)

[14] A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach, J Mater Chem B, 8 (2020) 7365-7374.

[15] Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy, Advanced Science, 7 (2020).

[16] Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy, Adv. Mater., 32 (2020).

[17] Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination, Adv. Mater., 32 (2020).

[18] Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications, Chin. J. Chem . 38 (2020) 911-923.

[19] The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B, Journal of Controlled Release, 321 (2020) 576-588.

[20] In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection, J Mater Chem B, 8 (2020) 6845-6856.

[21] Biochemical engineering in China, Rev. Chem. Eng., 35 (2019) 929-993.

[22] Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination, Nat Mater, 17 (2018) 187-194.

[23] Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine, Small, 14 (2018) 1704272.

[24] CaCO3-based nano-missile potentiates antigen delivery and cross-presentation, Journal of Controlled Release, 259 (2017) E123-E123.

[25] Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer, Advanced Science, 4 (2017) 1700083.

[26] PEGylated graphene oxide elicits strong immunological responses despite surface passivation, Nat Commun, 8 (2017) 14537.

[27] Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells, Adv. Mater., 28 (2016) 7929-7935.

[28] Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases, J Mater Chem B, 4 (2016) 2548-2552.

[29] Improving adjuvanticity of quaternized chitosan-based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect, Int J Pharm, 515 (2016) 84-93.

[30] Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales, Adv Healthc Mater, 5 (2016) 2872-2881.

[31] Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies, Colloid Surf. A-Physicochem. Eng. Asp., 500 (2016) 177-185.

[32] Superior Intratumoral Penetration of Paclitaxel Nanodots Strengthens Tumor Restriction and Metastasis Prevention, Small, 11 (2015) 2518-2526.

[33] Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages, Acs Appl. Mater. Inter., 7 (2015) 5239-5247.

[34] Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane, Nanoscale, 7 (2015) 4020-4030.

[35] Construction of Stable Chainlike Au Nanostructures via Silica Coating and Exploration for Potential Photothermal Therapy, Small, 10 (2014) 3619-3624.

[36] Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs, J Mater Chem B, 1 (2013) 3239-3247.

[37] Inducible graphene oxide probe for high-specific tumor diagnosis, Chemical Communications, 49 (2013) 3902-3904.

[38] Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression, Biomaterials, 34 (2013) 3912-3923.

[39] Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy, Biomaterials, 34 (2013) 8291-8300.

[40] Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD), Mol. Pharm., 9 (2012) 1736-1747.

[41] Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs, Adv. Funct. Mater., 21 (2011) 3446-3453.

[42] Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-Based Nanoparticles, Biomacromolecules, 12 (2011) 2440-2446.

[43] Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration, Biomacromolecules, 12 (2011) 4230-4239.

[44] Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity, Journal of Materials Chemistry, 21 (2011) 7105-7110.

[45] Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation, Nanomedicine, 5 (2010) 589-596.

International conference papers (in part):

[1] Hua Yue, Guanghui Ma. Exploration of the unique bio-interface effects of 2D material for biomedical application, UK-China International Particle Technology Forum VIII, 2021, Dali, China

[2] Hua Yue, Fumin Hu, Guanghui Ma. Cytosolic delivery of HBsAg and enhanced cellular immunity by pH responsive liposome. 11st Annual Conferences of Chinese Society of Particuology. 2022, Ximen, China

[3] Hua Yue, Wei Wei, Guanghui Ma. Exploration of micro-sized graphene oxide as tumor vaccine delivery system, APCChE 2019 (Australia-China-Japan Session), 2019, Sapporo, Japan

[4] Hua Yue, Wei Wei, Guanghui Ma. Exploration of micro-sized graphene oxide as “One but All” tumor vaccine. 2018, Hong Kong

​[5] Hua Yue, Wei Wei, Dezhi Ni, Weiwei Zhang, Nana Luo, Zhiguo Su and Guanghui Ma. Exploration of micro-sized graphene oxide as “One but All” tumor vaccine delivery system. 7^th Vaccine & ISV Annual Global Congress. 2013. Sitges, Spain
[6] Hua Yue, Wei Wei, Guanghui Ma and Zhiguo Su. Particle Size Affects the Cellular Response in Macrophages The 5th SBE International Conference on Bioengineering and Nanotechnology (ICBN), 2010. Singapore.
[7] Hua Yue, Wei Wei, Guanghui Ma, Zhiguo Su. Enhanced immune responses to HBsAg after immunization with PLA particle-based antigen formulations. The 4th International Pharmaceutical Symposium Novel Drug Delivery Systerms: Research and Application, 2009. Shanghai, China
[8] Hua Yue, Wei Wei, Zhanguo Yue, Piping Lv, Lianyan Wang, Guanghui Ma and Zhiguo Su. Particle Size Affects the Cellular Response in Macrophages. ICBN, 2010. Singapore

Research Directions：

• Biochemical engineering

• Pharmaceutics

• Nano/Micro particle based delivery system (for vaccines and tumor therapy)

• Low-dimensional materials

2020 First Prize, Natural Science Award of Chinese Particuology Society (R06)

2020 First Prize, Basic Research Award of Chinese Chemical Society (R10)

2015 President of Youth Innovation Promotion Association, Institute of Process Engineering

2014 Outstanding Paper, China Materials Conference

2013 Member of Young Innovation Promotion Association, Chinese Academy of Sciences

2012 Outstanding Graduate of Beijing

2012 President's Award for Excellent student, Chinese Academy of Sciences

2012 "Outstanding Graduate Student in Medical Science" awarded by Beijing Institute of Life Sciences and Sanofi Pasteur

2010 Student Travel Award, ICBN 2010, Singapore (only four students from China received the award)

2010 First Prize in Microscopic Photography Competiti