The main research interests in my lab are concerned with development of biomedical drugs for neuronal diseases, including computer-aided structural optimizations of antibody drugs, artificial intelligence based design of genetic drugs, and design of new therapeutic drug vehicles to improve the efficiency of drugs. The diseases that we are currently studing are neuronal disorders, such as Alzheimer Disease, Parkinson's Disease, and Huntington Disease, etc. The projects in the lab utilized the state-of-the-art computational approach to solve the problems in preclinical biomedical drug development.

2008/08 – 2013/11   University of Kansas Medical Center                                           USA

 Department of Biochemistry and Molecular Biology

                                           Ph.D. in Biochemistry and Molecular Biology

2005/08 - 2008/07   Tsinghua University                                                                          China

                                     School of Life Sciences

                                           M.S. in Biological Science

2017/07 – Present   University of Chinese Academy of Sciences               China

                                        School of Chemical Engineering

                                       Associate Professor

2017/07 – Present   Chinese Academy of Sciences                                        China

                                        Institute of Process Engineering

                                        State Key Laboratory of Biochemical Engineering

                                       Associate Professor

2014/03 – 2017.07   Chinese Academy of Sciences                                        China

                                        Institute of Process Engineering

                                        State Key Laboratory of Biochemical Engineering

                                        Assistant Professor

2009/05 – 2013.11   University of Kansas Medical Center                              USA

                                        Department of Biochemistry and Molecular Biology

                                        Research Associate

      2008/08 – 2009/05   University of Kansas Medical Center                              USA

                                         Interdisciplinary Graduate Program in Biomedical Sciences

                                         Teaching Assistant

Liu SY, Lu S*, Yu XL, Yang SG, Liu W, Liu XM, Wang SW, Zhu J, Ji M, Liu DQ, Zhang ZP, Liu RT. (2017) Fruitless wolfberry-sprout extract rescued cognitive deficits and attenuated neuropathology in Alzheimer's disease transgenic mice. Curr Alzheimer Res.

Liu DQ, Lu S*, Zhang LX, Ji M, Liu SY, Wang SW, Liu RT. (2018) An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice. J Control Release, 273:1-12.

Huang N*, Lu S*, Liu XG, Zhu J, Wang YJ, Liu RT. (2017) PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice. Oncotarget 8, 81001-81013.

Zhang YX, Wang SW, Lu S, Zhang LX, Liu DQ, Ji M, Wang WY, Liu RT. (2017) A mimotope of Aβ oligomers may also behave as a β-sheet inhibitor. FEBS Lett., 591(21):3615-3624.

Zha J, Liu XM, Zhu J, Liu SY, Lu S, Xu PX, Yu XL, Liu RT. (2016) A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep., 6:36631.

Yang S*, Liu W*, Lu S*, Tian YZ, Wang WY, Ling TJ, Liu RT. (2016) A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation. ACS Chem Neurosci., 7(4):505-518.

Zhou WW, Lu S, Su YJ, Xue D, Yu XL, Wang SW, Zhang H, Xu PX, Xie XX, Liu RT. (2014) Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med., 74:50-63.

Lu, S., Lee, K.K., Harris, B., Xiong, B., Slaughter, B., Seidel, C., Gerton, J.L. (2014) Cohesin acetyltransferase Eco1 regulates genome stability through coordinating rDNA transcription and replication. EMBO Rep., 15(5):609-617.

Bose, T., Lee, K.K., Lu, S., Xu, B., Harris, B., Slaughter, B., Unruh, J., Garrett, A., McDowell, W., Box, A., et al. (2012). Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells. PLoS genetics 8, e1002749.

Lu, S., Goering, M., Gard, S., Xiong, B., McNairn, A.J., Jaspersen, S.L., and Gerton, J.L. (2010). Eco1 is important for DNA damage repair in S. cerevisiae. Cell cycle 9, 3315-3327.

Xiong, B., Lu, S., and Gerton, J.L. (2010). Hos1 is a lysine deacetylase for the Smc3 subunit of cohesin. Current biology 20, 1660-1665.

Lu, S., Xu, X., Zhao, W., Wu, W., Yuan, H., Shen, H., Zhou, C., Li, L.S., and Ma, L. (2010). Targeting of embryonic stem cells by peptide-conjugated quantum dots. PloS one 5, e12075.