Email：songfr@ciac.jl.cn
Telephone：0431-85262613
Mobile phone：
Address：5625 Renmin Street, Chanchun, China
Postcode：130022
Research Areas
Application study of mass spectrometry and other modern analytical , including:
l Quality control and jJudging Methods for Chinese medicinal materials and relative products of Chinese medicine
l Separation and analysis for Chinese medicine and natural Products.
l Research of New Drugs and Health Products
l Screening methods for iinherited metabolic disorders
Education
Ø B.S., in Chemical Engineering(1984), Dalian Polytechnic University, Dalian, P. R. China
Ø M.S., in Mass Spectrometry/Chemistry(1998), Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China
Ø Ph. D, in Mass Spectrometry/Chemistry(2005) Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China
Experience
Work Experience
2008-Present Professor., Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
20 2001-2008 Associate Professor., Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
2001-2002 Research Assistant, Hong Kong Baptist University, Hong
Kong.
1992-2001 Assistant Professor., Changchun Institute of Applied
Chemistry , Chinese Academy of Sciences
1987-1992 Research Assistant, Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
Honors & Distinctions
l First Grade Science and Technology Development Award of Jilin Province(2001, 2006, No3)
l Secondary Grade Science and Technology Development Award of Jilin Province(2002, No3 in CIAC)
l Secondary Grade Science and Technology Development Award of The Chinese Academy of Agricultural Sciences(2004, No2 in CIAC)
l Third Grade Science and Technology Development Award of Jilin Province(2006, No2 in CIAC)
Publications
Papers
1. Fengrui Song，Meng Cui，Zhiqiang L iu，Biao Yu，Shuying Liu Multiple-stage tandem mass spectrometry For differentiation of isomeric saponins. Rapid Commun. Mass Spectrom.,2004；18:2241-2248
2. Fengrui Song, Zhiqiang Liu, Shuying Liu, Zongwei Cai. Differentiation and identification of ginsenoside isomers by electrospray ionization tandem mass spectrometry, Anal. Chim. Acta , 2005，531：69-77
3. Song FR, Liu Ning, Yan CY,Liu ZQ, Liu SY, Non-covalent Interaction Between Oligodeoxynucleotide and Alkaloid Compounds via Negative Ion Electrospray Ionization Mass Spectrometry（I）, Chem. J. Chinese U., 2004, 25（10）：2830－1832
4. Song FR, Yan CY,Liu Ningh, Liu ZQ, Liu SY. Studies on the Non-covalent Complexes between Oligodeoxynucleotide and Compounds from Some Chinese Herbs,Chinese J. Anal. Chem.2005,33（12）:1743-1746
5. Liu SY, Song FR,The Application of Mass Spectrometry on the Analysis of Chinese Medicine, Modern Methoology in Chinese Medicine Study, Chemical Industry Press.,2004, 76－84
6. Chen ML, Song FR, Guo MQ, Liu ZQ, Liu SY. Analysis of Flavonoid Constituents from Leaves of Acanthopanax Senticosus Harms by Electrospray Tandem Mass Spectrometry, Rapid Commun. Mass Spectrom., 2002, 16: 264~ 271
7. Cai ZW, Song FR, Yang MS, Capillary liquid chromatographic –high -resolution mass spectrometric analysis of ribonucleotides .J. Chromatography A., 2002, 976, 135-143
8. Guo MQ, Song FR, Bai Y, Liu ZQ, Liu SY Rapid Analysis of A Triterpenoid Saponin Mixture from Plant Extracts by Electrospray Lonization Tandem Mass Spectrometry. Anal. Sci., 2002, 18(4) 481-484
9. Yong Wang, Fengrui Song. Qingxuan Xu, Zhiqiang Liu and Shuying Liu Characterization of aconitine-type alkaloids in the flowers of Aconitum kusnezoffii by electrosprayionization tandem mass spectrometry. J.Mass Spectrom. 2003;38:962-970
10. Mingquan Guo, Fengrui Song, Zhiqiang Liu. and Shuying Liu, Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandemmass spectrometry, J. Mass Spectrom. 2004; 39: 594–599
11. Yu Bai, Fengrui Song, Maolian Chen, Junpeng Xing, Zhiqiang Liu and Shuying Liu, Application of Multistage Tandem Electrospray Ionisation Mass Spectrometry (ESI-MSn) to characterisation of Rutin-Met al Complex, Anal.Sci., 2004,20, 1147 - 1151.
12. Wei Wu, Fengrui Song, Cunyu Yan, Zhiqang Liu Shuying Liu.，Structursal analyses of protoberberine alkaloids in medicine herbs by using ESI-FT-ICR-MS and HPLC-ESI-MS， J. pharm. Biomed. Anal.，2005, 378: 437-446，
13. Guo, MQ; Song, FR; Liu, ZQ; Liu, SY，Characterization of triterpenoidic saponin mixture in crude extracts from leaves of Acanthopanax senticosus Harms by saponin structural correlation and mass spectrometry，Anal. Chim. Acta ,2006，557 (1-2): 198-203
14. Xu Zhang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Investigation of the hydrolysis of ginsenosides by high performance liquid chromatography –electrospray ionization mass spectrometry. Planta Medica ,2007,73,1225-1229
15. Xin Huang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Studies on lignan constituents from Schisandra Chinensis(Turcz.) Bail. Fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. J.Mass Spectrom., 2007;42:1148-1161
16. Xin Huang, Fengrui Song, Zhiqiang Liu, Shuying Liu, Structural characterization and identification of dibenzocyclooctadiene lignans in Fructus Schisandrae using electrospray ionization ion trap multiple-stage tandem mass spectrometry and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry. Anal. Chim. Acta, 2008,19:141-147
17. Wei Li, Fengrui Song, Shuying Liu, Zhiqiang Liu. Qualitative and semi-quantitative analysis of quaternary alkaloids in the coptis-scute herb couple by using electrospray mass spectrometry Chem. Res. Chinese U. 2008, 24(2), 162-166
18. Zhaofu Wang, Meng Cui, Fengrui Song, Lin Lu, Zhiqiang Liu, Shuying Liu Evaluation of Flavonoids Binding to DNA Duplexes by Electrospray Ionization Mass Spectrometry . J Am Soc Mass Spectrom, 2008,43(3):327-335
19. Mingquan Guo, Suoqing Zhang, Fengrui Song, Daowu Wang, Zhiqiang Liu and Shuying Liu Studies on the non-covalent complexes between noleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 2003;38: 723-731
20. Wu Wei, Liu ZQ, Song FR, Liu SY. Structural analysis of selected characteristic flavones by electrospray tandem mass spectrometry. Anal. Sci. 2004; 20: 1103-1105.
21. Hongjuan Dong , Zhiqiang Liu , Fengrui Song , Zhan Yu , Huilin Li, Shuying Liu. Structural analysis of monoterpene glycosides extracted from Paeonia lactiflora Pall. using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry and high performance liquid chromatography – electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom..2007,21(19),3193-3199
Patents
Most inventive patents in quality control and processing technics of Chinese medicinal materials
Conferences
1、 Quality control and mass spectrometry fingerprint for Chinese Medicinal Materials, 9thChinese Conference on Mass Spectrometry. Sep, 2008,Hainan
2、 Multiple-stage tandem mass spectrometry For differentiation of isomeric saponins, 10thBCEIA, Beijing, 2003.
3、 Study on Non-covalent Complexes between single-strand oligodeoxynucleotide and flavone compounds by elextrospry mass spectrometry.，1st World Chinese Conference on Mass Spectrometry. July, 2006, Xinjiang
4、 Study on Non-covalent Complexes between Double-Stranded DNA and Alkaloid Compounds by Electrospray Ionization Mass Spectrometry. 13thChinese Conference on Organic Mass Spectrometry. Sep, 2005,Guangzhou