‍‍Our group is working on the relationship between structures and functions of biomaterials applied in the biomedical field. The research interest is focused on the multifunctional nanoformulations based on the biomaterials with therapeutic drugs (nucleic acid, chemotherapy drugs, etc.)、prophylactic and therapeutic vaccine formulation（HIV DNA vaccine, etc.）and diagnosis contrast agents(MR imaging contrast agent) for prevent 、therapy and diagnosis of malignant diseases (such as cancer, neurodegenerative diseasesand etc.).

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‍‍‍‍‍‍2004     University of Strasbourg, FRANCE  Ph.D. 

2001     Tianjin University,  M.S. 

1997     Tianjin University,  B.S. ‍‍‍‍‍‍

‍‍‍‍2010-Present: Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA

2008-2010: Assistant Professor, INSERM, FRANCE

1. Jie Shen#, Zhiguo Lu#, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 33, 27, 2101993.

2. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Zhiguo Lu, Jun Yang, Xin Zhang*. Self-catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021, 34, 1, 2105711.

3. Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*. Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment. Advanced Materials, 2018, 18, 30,1705054.

4. Yan Li#, Linying Liu#, Weihong Ji#, Huan Peng, Ruichen Zhao, Xin Zhang*.Strategies and materials of “SMART” non-viral vectors: Overcoming the barriers for brain gene therapy. Nano Today, 2020, 35,101006.

5. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Xin Zhang*.Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases. Advanced Drug Delivery Reviews, 2022, 180,114029.

6. Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 46, 27,1703967.

7. Ruiyuan Liu#, Jun Yang#, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang*. An ‘Amyloid-β Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial Dysfunction. Advanced Science, 2020, 2, 7, 1901555.

8. Linying Liu^#,Yan Li^#, Huan Peng, Ruiyuan Liu,Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang*. Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease. Science Advances, 2020, 6, 50, eaba3967.

9. Huan Peng#,Yan Li#, Weihong Ji, Ruichen Zhao, Zhiguo Lu, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Jingwen Wang, Wenli Wang, Jun Yang,  Xin Zhang*. Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson’s Disease. ACS Nano, 2022,16,1,869-884.

10. Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140,11, 4164−4171.

11. Weihong Ji#, Yan Li#, Ruiyuan Liu, Zhiguo Lu, Linying Liu, Zhuyan Shi, Jie Shen, Xin Zhang*. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a ‘‘nanoguard’’ for synergistic treatment of synucleinopathies. Materials Horizons, 2021, 4, 8, 1199-1206.

12. Linying Liu#, Yan Li#, Ruiyuan Liu, Qi Shen, Yanhui Li, Zhuyan Shi, Jie Shen, Weihong Ji, Xin Zhang*. Switchable Nanoparticle for Programmed Gene-chem Delivery with Enhanced Neuronal Recovery and CT Imaging for Neurodegenerative Disease Treatment. Materials Horizons, 2019, 9, 6, 1923-1929.

13. Qi Shen#, Jun Yang#, Ruiyuan Liu, Linying Liu, Jinchao Zhang, Shigang Shen*, Xin Zhang*.Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy. Materials Horizons, 2019, 4, 6, 810-816.

14. Zhiguo Lu#, Jianze Wang#, Lina Qu, Guanghan Kan,Tianlu Zhang, Jie Shen,Yan Li, Jun Yang, Yunwei Niu, Zuobing Xiao,Yinghui Li*, Xin Zhang*. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. Bioact. Mater. 2020, 4, 5, 1127-1137.

15. Yan Li*, Weihong Ji, Huan Peng, Ruichen Zhao, Tianlu Zhang, Zhiguo Lu, Jun Yang, Xin Zhang*. Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery. Theranostics, 2021, 9, 11, 4452-4466.

16. Jun Yang#, Zhuyan Shi#, Ruiyuan Liu, Yanyue Wu, Xin Zhang*. Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology. Theranostics, 2020, 7, 10, 3223-3239.

17. Yanhui Li, Zixuan Chen, Zhiguo Lu, Qinghu Yang, Linying Liu, Zhaotan Jiang, Liqun Zhang, Xin Zhang*, Hong Qing*. “Cell-addictive” dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway. Theranostics, 2018, 19, 8, 5469-5481.

18. Jingli Chen#, Jun Yang#, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang*, Xin Zhang*. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. Theranostics, 2017, 17, 7, 4149-4167.

Biomaterials; Drug delivery; Diagnostic imaging; Vaccine adjuvant

Graduated students

Ph.D Yan Li

Ph.D Hongmei Liu

Ph.D Zhuyan Shi

Ph.D Ruiyuan Liu

Ph.D  Zhiguo Lu

Ph.D Linying Liu

Master Heng Deng

Master Yanqi Zhong

Master Dandan Sun

Students

Ph.D Weihong Ji

Ph.D Jie Shen

Ph.D Yanyue Wu

Ph.D RuiChen Zhao

Master Huan Peng

Master   Yiwan Geng

The winner of “National Excellent Young Scientists Fund” in 2015; 

“Young Scientist Award” by “Chinese Society for Biomaterials” in 2018;

“Young Innovator Award in Nanobiotechnology” by Nano Research in 2018;  

“First Prize of Ministerial and Provincial-Level Science and Technology Awards” in 2020;

The membership of Editorial Board of Theranostics and Bioactive Materials;

 A member of the council of “Nanobiology Academic Subgroup, Biophysical Society of China”;

A member of the youth committee of “Chinese Society for Biomaterials”.